INT79767

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 5.14
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
smooth muscle 2
myocytes 1
muscle 1
gastric smooth muscle 1
microglia 1
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 72 100.00 Very High Very High Very High
dexamethasone 5 99.72 Very High Very High Very High
Calcium channel 56 99.60 Very High Very High Very High
Trigeminal ganglion neurons 240 99.32 Very High Very High Very High
B1 receptor 194 96.00 Very High Very High Very High
qutenza 51 94.32 High High
Peripheral nervous system 1 94.12 High High
Central nervous system 19 92.96 High High
Spinal cord 59 91.68 High High
Triptan 128 91.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 105 100.00 Very High Very High Very High
Diabetes Mellitus 130 99.16 Very High Very High Very High
Hypothermia 66 98.38 Very High Very High Very High
Recurrence 2 96.40 Very High Very High Very High
Encephalitis 2 94.80 High High
Cluster Headache 64 89.60 High High
Bordatella Infection 24 85.20 High High
Ganglion Cysts 66 79.84 Quite High
Pain 57 77.04 Quite High
Hyperglycemia 16 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone prevented or abolished local expression of EMAP II and AIF-1 at days 10-16.
Negative_regulation (abolished) of AIF-1 associated with dexamethasone
1) Confidence 0.42 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.13 Pain Relevance 0.67
To the best of our knowledge, this is however the first report showing a decrease of Iba-1 immunoreactivity after fluorocitrate treatment.


Negative_regulation (decrease) of Iba-1
2) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.79 Pain Relevance 0.61
This result is in accordance with the literature showing that minocycline caused a marked reduction of Iba-1 immunoreactivity in diabetes [28].
Negative_regulation (reduction) of Iba-1 associated with diabetes mellitus
3) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.87 Pain Relevance 0.68
Mildronate per se at doses of 50 and 100 mg/kg did not significantly influence the expression of IBA-1, but the co-administration of mildronate and 6-OHDA showed a tendency to decrease the number of IBA-1-positive cells (18 ± 2 vs. 32 ± 8, p = 0.14; and 17 ± 2 vs. 32 ± 8, p = 0.15, respectively).
Negative_regulation (decrease) of IBA-1-positive
4) Confidence 0.18 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0 Pain Relevance 0
-Aga or SNX-482 likely contributed to the blockade of zolmitriptan IBa inhibition.
Negative_regulation (inhibition) of IBa
5) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0 Pain Relevance 0.08
Thus, PTX pretreatment prevented the inhibition of IBa by zolmitriptan, while IBa was depressed by zolmitriptan without the PTX pretreatment.
Negative_regulation (inhibition) of IBa
6) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.09 Pain Relevance 0.10
Thus, PTX pretreatment prevented the inhibition of IBa by zolmitriptan, while IBa was depressed by zolmitriptan without the PTX pretreatment.
Negative_regulation (depressed) of IBa
7) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.08 Pain Relevance 0.11
P/Q- and possibly R-type calcium channels contributed to the inhibition of IBa by zolmitriptan.
Negative_regulation (inhibition) of IBa associated with calcium channel
8) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.37 Pain Relevance 0.64
Characteristics of IBa inhibited by zolmitriptan were pharmacologically determined by using a variety of selective Ca2+ channel blockers.
Negative_regulation (inhibited) of IBa
9) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.07 Pain Relevance 0.12
The present study demonstrated that the inhibition of zolmitriptan-sensitive IBa in small-medium TGNs depended mainly on activation of P/Q- and R-type channels.
Negative_regulation (inhibition) of IBa associated with trigeminal ganglion neurons
10) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.06 Pain Relevance 0.47
M occasionally inhibited IBa.


Negative_regulation (inhibited) of IBa
11) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.08 Pain Relevance 0.22
-Aga and SNX-482 reduced the inhibition of IBa by zolmitriptan.
Negative_regulation (inhibition) of IBa
12) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0 Pain Relevance 0.07
In summary, this study provides evidences that polyamines decreased IBa in concentration-dependent manner and also induced relaxation in guinea-pig gastric smooth muscle.



Negative_regulation (decreased) of IBa in gastric smooth muscle
13) Confidence 0.04 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0
In this study, we applied various concentrations of polyamines to the outside of the membrane in guinea-pig gastric smooth muscle, and observed relaxation of muscle and inhibition of IBa, which was similar to the results by others.
Negative_regulation (inhibition) of IBa in muscle
14) Confidence 0.04 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0
These findings are the same results as those observed in intestinal smooth muscle of guinea-pig: Gomez and Hellstrand (14) reported that IBa in guinea-pig intestinal smooth muscle was inhibited by spermine in a reversible manner (IC50=0.8 mM).
Negative_regulation (inhibited) of IBa in smooth muscle
15) Confidence 0.04 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0.04
One mM spermine and putrescine were found to decrease IBa at membrane potential range of -20~+50 mV tested (n=5 and 6, respectively; p<0.05).


Negative_regulation (decrease) of IBa
16) Confidence 0.04 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0
In contrast, putrescine inhibited IBa in guinea-pig gastric myocytes without affecting steady-state activation and inactivation curves (Fig. 7D).
Negative_regulation (inhibited) of IBa in myocytes
17) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0.03
As shown in Fig. 6A, B, spermine significantly inhibited IBa in a concentration-dependent and reversible manner, and this inhibitory effect of spermine was maintained over the whole range of I/V relationship (Fig. 7A).
Negative_regulation (inhibited) of IBa
18) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0.04
Inhibitory effect of spermine on IBa was observed at a wide range of test potentials of current/voltage (I/V) relationship (p<0.05), and steady-state activation of IBa was shifted to the right by spermine (p<0.05).
Negative_regulation (effect) of IBa
19) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0.04
To our best knowledge, this study is the first report showing that putrescine inhibits contraction and IBa in GI smooth muscle.
Negative_regulation (inhibits) of IBa in smooth muscle
20) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0

General Comments

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