INT79768

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.15
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
spinal 2
Paw 2
lateral 2
striatum 2
CNS 2
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 21 99.98 Very High Very High Very High
Central nervous system 25 99.08 Very High Very High Very High
Dorsal horn 47 98.24 Very High Very High Very High
withdrawal 23 95.96 Very High Very High Very High
Peripheral nervous system 4 94.64 High High
c fibre 74 94.12 High High
antagonist 26 93.92 High High
Cannabinoid 9 90.80 High High
Sciatic nerve 31 90.36 High High
Neuritis 8 90.16 High High
Disease Link Frequency Relevance Heat
Encephalitis 4 98.44 Very High Very High Very High
Recurrence 8 98.00 Very High Very High Very High
Uveitis 16 97.00 Very High Very High Very High
Multiple Sclerosis 16 96.48 Very High Very High Very High
Neuritis 8 90.16 High High
INFLAMMATION 65 89.60 High High
Disease 53 79.48 Quite High
Neuropathic Pain 41 68.00 Quite High
Demyelinating Disease 2 58.96 Quite High
Neurodegenerative Disease 10 57.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone prevented or abolished local expression of EMAP II and AIF-1 at days 10-16.
Negative_regulation (prevented) of Gene_expression (expression) of AIF-1 associated with dexamethasone
1) Confidence 0.58 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.14 Pain Relevance 0.67
Dexamethasone prevented or abolished local expression of EMAP II and AIF-1 at days 10-16.
Negative_regulation (abolished) of Gene_expression (expression) of AIF-1 associated with dexamethasone
2) Confidence 0.43 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.13 Pain Relevance 0.67
In these cases, a smoldering expression of EMAP II and AIF-1 persisting long after cessation of neurological signs was observed.
Negative_regulation (smoldering) of Gene_expression (expression) of AIF-1
3) Confidence 0.42 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.03 Pain Relevance 0.61
Only rather limited expression of EMAP II and AIF-1 is seen in the normal central nervous system (CNS).
Negative_regulation (limited) of Gene_expression (expression) of AIF-1 in CNS associated with central nervous system
4) Confidence 0.42 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.29 Pain Relevance 0.66
In the present study, mildronate did not affect the level of IBA-1 in the 6-OHDA-lesioned striatum, but in the SN, it showed a tendency to decrease the expression of IBA-1.
Negative_regulation (decrease) of Gene_expression (expression) of IBA-1 in striatum
5) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.36 Pain Relevance 0.15
In both the groups, levels of Iba-1 expression were low except for a localized increase in Iba-1 immunoreactivity in the dorsal laminae of the ipsilateral side in the lateral L3/4 segments corresponding to the termination site of afferents damaged by the surgical incision to expose the sciatic nerve in the upper leg (Fig. 2).
Negative_regulation (levels) of Gene_expression (expression) of Iba-1 in lateral associated with sciatic nerve
6) Confidence 0.25 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0 Pain Relevance 1.04
Effect of CB1 and CB2 Receptor Blockade on spinal GFAP, Iba-1 and ED2/CD163 following Paw Incision
Negative_regulation (spinal) of Gene_expression (/) of Iba-1 in Paw
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.23
JWH015 was chosen because we have shown in vivo that it selectively acts on spinal microglial CBR2 in L5 nerve transection rats and reduces spinal Iba-1 expression in association with its anti-allodynic effects [13].
Negative_regulation (reduces) of Gene_expression (expression) of Iba-1 in spinal
8) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.20 Pain Relevance 0.50

General Comments

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