INT7977

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.79
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 2
arms 2
embryo 1
oocyte 1
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 99.36 Very High Very High Very High
Central nervous system 1 98.52 Very High Very High Very High
narcan 4 68.64 Quite High
antagonist 7 60.12 Quite High
Neuropeptide 1 25.00 Low Low
Pain 16 19.36 Low Low
agonist 28 5.00 Very Low Very Low Very Low
Onset of action 3 5.00 Very Low Very Low Very Low
Pain score 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 93 99.48 Very High Very High Very High
Recurrence 12 98.92 Very High Very High Very High
Endometriosis (extended) 5 51.24 Quite High
Cancer 17 50.00 Quite Low
Death 9 29.12 Quite Low
Pain 16 19.36 Low Low
Prostate Cancer 38 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Obesity 13 5.00 Very Low Very Low Very Low
Metastasis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondary efficacy variables included the percentage of cycles with oocyte retrieval; duration of gonadotropin therapy; total FSH dose; peak serum E2 levels; embryo transfer and implantation rates; chemical pregnancies (positive serum ?
Regulation (percentage) of in oocyte Gene_expression (dose) of FSH in embryo
1) Confidence 0.44 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC270000 Disease Relevance 0 Pain Relevance 0
How does even brief exposure to high estrogen levels through tamoxifen or FSH-letrozole stimulation affect the risk of breast cancer recurrence?
Regulation (affect) of Gene_expression (exposure) of FSH associated with recurrence and reprotox - general 1
2) Confidence 0.29 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397531 Disease Relevance 0.79 Pain Relevance 0.03
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Regulation (influence) of Gene_expression (synthesis) of stimulating hormone in follicle
3) Confidence 0.22 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.21
In the degarelix groups, median LH and FSH levels decreased rapidly and remained suppressed until the end of the study, whereas LH and FSH levels showed an initial increase for patients in the leuprolide group, and FSH levels did not fall to the same extent as they did in the degarelix arms.
Neg (not) Regulation (fall) of Gene_expression (levels) of FSH in arms
4) Confidence 0.09 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004563 Disease Relevance 0 Pain Relevance 0

General Comments

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