INT79770

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.28
Pain Relevance 6.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
microglial cells 5
small intestine 3
sciatic nerve 2
nerve 2
macrophages 1
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 40 100.00 Very High Very High Very High
cytokine 21 100.00 Very High Very High Very High
dexamethasone 11 100.00 Very High Very High Very High
Sciatic nerve 165 98.96 Very High Very High Very High
Dorsal horn neuron 16 98.92 Very High Very High Very High
c fibre 387 98.76 Very High Very High Very High
central sensitization 91 97.72 Very High Very High Very High
Dorsal horn 180 97.28 Very High Very High Very High
medulla 82 97.12 Very High Very High Very High
ischemia 122 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 50 100.00 Very High Very High Very High
Hypersensitivity 47 99.90 Very High Very High Very High
Multiple Sclerosis 8 97.56 Very High Very High Very High
Cv Unclassified Under Development 98 96.44 Very High Very High Very High
Pain 77 96.28 Very High Very High Very High
Neuritis 4 95.84 Very High Very High Very High
Uveitis 8 95.32 Very High Very High Very High
Neuropathic Pain 84 93.96 High High
Nervous System Injury 140 92.24 High High
Disease 46 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of autoantigen and dexamethasone treatment on expression of endothelial-monocyte activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis.
Regulation (Effects) of Gene_expression (expression) of allograft-inflammatory factor-1 in microglial cells associated with multiple sclerosis, inflammation, uveitis, neuritis, dexamethasone and cytokine
1) Confidence 0.45 Published 1999 Journal Acta Neuropathol. Section Title Doc Link 9928822 Disease Relevance 1.19 Pain Relevance 0.59
C-fibre stimulation of neonatal sciatic nerve fails to induce behavioural hypersensitivity or to alter Iba-1 expression pattern
Neg (fails) Regulation (alter) of Gene_expression (expression) of Iba-1 in sciatic nerve associated with c fibre, hypersensitivity and sciatic nerve
2) Confidence 0.36 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.17 Pain Relevance 1.04
There were also no significant changes in the Iba-1 expression pattern in either of the groups.
Neg (no) Regulation (changes) of Gene_expression (expression) of Iba-1
3) Confidence 0.36 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.29 Pain Relevance 0.68
Furthermore, there was no change in IBA-1 and GFAP expression, compared with that in sham-operated controls (Figure 1H and 1M).


Neg (no) Regulation (change) of Gene_expression (expression) of IBA-1
4) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.43 Pain Relevance 0.36
Compared with sham-operated controls, there was no change in IBA-1 (a marker of microglia and monocytic lineage) and GFAP (a marker of astrocytes) expression (Figure 1G and 1L).


Neg (no) Regulation (change) of Gene_expression (expression) of IBA-1 in microglia
5) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.44 Pain Relevance 0.35
The pattern of Iba-1 expression in sham-operated and A?
Regulation (pattern) of Gene_expression (expression) of Iba-1
6) Confidence 0.26 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0 Pain Relevance 1.05
There were no differences in Iba-1 expression between the groups at the 3 h time point.
Neg (no) Regulation (differences) of Gene_expression (expression) of Iba-1
7) Confidence 0.26 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0 Pain Relevance 0.60
Mildronate at 50 and 100 mg/kg did not significantly influence IBA-1 expression in comparison to the control group.
Neg (not) Regulation (influence) of Gene_expression (expression) of IBA-1
8) Confidence 0.26 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0 Pain Relevance 0
Unfortunately, many studies defined microglial activation only based on altered expression of Iba1 or OX-42 (CD11b), which lead to controversies when trying to link microglial activation and pain states, because the direct role of Iba1 and CD11b in neuropathic pain genesis is unclear.
Regulation (altered) of Gene_expression (expression) of Iba1 associated with pain and neuropathic pain
9) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.04 Pain Relevance 0.90
The hypersensitivity and alterations in Iba-1 expression pattern are not seen in neonatal rats identifying a potentially important maturational process that may underpin the inability of young animals to exhibit neuropathic pain behaviours following nerve injury.
Regulation (alterations) of Gene_expression (expression) of Iba-1 in nerve associated with nervous system injury, hypersensitivity and neuropathic pain
10) Confidence 0.16 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.54 Pain Relevance 0.67
Effects of autoantigen and dexamethasone treatment on expression of endothelial-monocyte activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis.
Regulation (Effects) of in macrophages Gene_expression (expression) of allograft-inflammatory factor-1 in microglial cells associated with multiple sclerosis, inflammation, uveitis, neuritis, dexamethasone and cytokine
11) Confidence 0.15 Published 1999 Journal Acta Neuropathol. Section Title Doc Link 9928822 Disease Relevance 1.19 Pain Relevance 0.59
Unfortunately, however, we do not know the reasons of why larger polyamine such as spermine inhibits VDCCL and contraction more effectively in guinea-pig gastric smooth muscle, whereas smaller polyamine like putrescine is ineffective in regulating contraction and IBa in small intestine and colon.
Regulation (regulating) of Gene_expression (contraction) of IBa in small intestine
12) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0
Unfortunately, however, we do not know the reasons of why larger polyamine such as spermine inhibits VDCCL and contraction more effectively in guinea-pig gastric smooth muscle, whereas smaller polyamine like putrescine is ineffective in regulating contraction and IBa in small intestine and colon.
Regulation (regulating) of in colon Gene_expression (contraction) of IBa in small intestine
13) Confidence 0.01 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0

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