INT7978

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1992
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 5.60
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl)
Anatomy Link Frequency
mammary gland 2
embryos 2
Th1 cell 1
brain 1
forebrain 1
Nsdhl (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 175 100.00 Very High Very High Very High
Potency 45 100.00 Very High Very High Very High
antagonist 10 95.16 Very High Very High Very High
imagery 25 92.96 High High
Pain threshold 1 91.56 High High
Multiple sclerosis 25 90.08 High High
Chronic pancreatitis 1 90.00 High High
midbrain 30 84.60 Quite High
Bioavailability 5 81.84 Quite High
Analgesic 1 81.60 Quite High
Disease Link Frequency Relevance Heat
Fatigue 3 100.00 Very High Very High Very High
Apoptosis 62 99.28 Very High Very High Very High
Urological Neuroanatomy 20 98.40 Very High Very High Very High
Pancreatic Cancer 4 97.00 Very High Very High Very High
Galactorrhea 20 95.32 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 5 93.96 High High
Targeted Disruption 107 93.28 High High
Pain 33 91.56 High High
Biliary Cancer 2 91.24 High High
Autoimmune Disease 20 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of BPA in amniotic fluid at 15–18 weeks of gestation have been shown to be 5-fold higher than serum levels in both pregnant and nonpregnant women, suggesting a possible accumulation of BPA in the early embryo (Ikezuki et al. 2002), although Domoradzki et al. (2003) could not confirm this in animal experiments.
Spec (possible) Positive_regulation (accumulation) of BPA in amniotic fluid
1) Confidence 0.43 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.42 Pain Relevance 0
The BPa, fc, EMG amplitude and perceived fatigue increased early during all protocols and continued to increase throughout the exercise period.
Positive_regulation (increased) of BPa associated with fatigue
2) Confidence 0.39 Published 1993 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 8149933 Disease Relevance 0.47 Pain Relevance 0.09
Thus, in our hands the relative potency of BPA seems to be higher in utero than in vitro on ER-?
Positive_regulation (potency) of BPA associated with potency
3) Confidence 0.31 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.07 Pain Relevance 0.15
Like DES, BPA showed a transient induction of luciferase activity in embryos; thus, estrogenic potency of BPA is compared with DES rather than with EP.
Positive_regulation (potency) of BPA in embryos associated with potency
4) Confidence 0.31 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.09 Pain Relevance 0.08
One explanation for a higher estrogenic potency of BPA in utero versus in vitro could be that in vivo BPA is converted to metabolites with enhanced estrogenicity (Ben-Jonathan and Steinmetz 1998; Yoshihara et al. 2004), although others have shown that BPA is mainly metabolized to a less active metabolite BPA monoglucuronide (Domoradzki et al. 2003; Pottenger et al. 2000).
Positive_regulation (metabolized) of BPA associated with potency
5) Confidence 0.31 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.12 Pain Relevance 0.19
BPA injection of only female rats causes dose-dependent increases in PG receptor cells in the preoptic and ventromedial areas of the hypothalamus.146,147 BPA also increases PG receptor mRNA in the frontal cortex of ovariectomized female rats.148

Luteinizing Hormone and Testosterone.

Positive_regulation (increases) of BPA in frontal cortex associated with urological neuroanatomy
6) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.72 Pain Relevance 0.03
Morphometric analysis of the mammary gland: response to BPA
Positive_regulation (response) of BPA in mammary gland
7) Confidence 0.25 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.15 Pain Relevance 0
One of the most striking observations was that the sensitivity of the mammary gland to E2 increased in perinatally BPA-exposed CD-1 females that were ovariectomized before puberty (Munoz de Toro et al. 2005).
Positive_regulation (increased) of BPA in mammary gland
8) Confidence 0.25 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.39 Pain Relevance 0
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
Neg (not) Positive_regulation (increases) of BPA in pituitary associated with galactorrhea
9) Confidence 0.21 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.51 Pain Relevance 0.11
BPA also attenuates DA D3 receptor–mediated G-protein activation by 7-OH-DPAT in the mouse limbic forebrain.177 In this case, BPA acts more as an antipsychotic,178 but attenuation of prenatal DA D3 may have entirely different effects than enhanced D3 activation in adult life.
Positive_regulation (acts) of BPA in forebrain associated with dopamine
10) Confidence 0.19 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.12 Pain Relevance 0.64
Bisphenol A diglycidyl ether (BADGE), formed by a coreaction of BPA with epichlorohydrin, is a PPAR-gamma antagonist and endocrine disruptor used in liquid epoxy resins.194 BADGE has potential as an antitumor drug that induces apoptosis through Bax, caspases-2 and -8, and stimulation of mitochondrial release of apoptosis-inducing factor.195 BADGE may form BPA endogenously as shown in BADGE-exposed workers.196 BADGE induces several cellular reactions through antagonism of PPAR-gamma including disruption of microtubule networks,197 increase of the severity and duration of experimental allergic encephalomyelitis which is a Th1 cell–mediated autoimmune disease model of MS,198,199 induction of cell death in astrocytomas,200 and blockage of 15-dioxy-PGJ(2)–induced neuronal differentiation of rat embryonic midbrain cells.201

Norepinephrine Transporter.

Positive_regulation (induces) of BPA in Th1 cell associated with anaplastic astrocytoma, multiple sclerosis, autoimmune disease, antagonist, midbrain, apoptosis, death and experimental autoimmune encephalomyelitis
11) Confidence 0.19 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.32 Pain Relevance 0.26
Eight hours after exposure to 1 mg/kg BPA, ER transactivation could be significantly induced in the embryos.
Positive_regulation (transactivation) of BPA in embryos
12) Confidence 0.14 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247619 Disease Relevance 0.09 Pain Relevance 0.12
Elevated levels of BPA- and VVA-reactive antigens were detected in 41% and 31%, respectively, of pancreatic cancer sera samples.
Positive_regulation (levels) of BPA associated with pancreatic cancer
13) Confidence 0.08 Published 1992 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1359630 Disease Relevance 0.79 Pain Relevance 0.09
BPA rapidly releases DA from PC12 cells,176 and treatment of mouse astrocyte/neuronal cells with BPA enhances Ca2+ response to DA.102 In males exposed prenatally and neonatally to BPA, DA D1 receptor mRNA is upregulated in the whole brain.174
Positive_regulation (upregulated) of BPA in brain associated with dopamine
14) Confidence 0.08 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.19 Pain Relevance 0.70
From the DFT results, various quantum chemical based descriptors were computed but the QSAR results showed that the descriptors based on frontier electron density and a new DFT based quantum chemical descriptor, nucleus independent chemical shift (NICS) are likely to be responsible for the in vitro inhibiting activity of BPA and MPBA.
Spec (likely) Positive_regulation (responsible) of BPA in nucleus
15) Confidence 0.02 Published 2009 Journal J Mol Model Section Abstract Doc Link 19266221 Disease Relevance 0.16 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox