INT79780

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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 5.19
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp4a3)
Anatomy Link Frequency
capsules 1
Caco-2 1
colon 1
Cyp4a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 8 97.68 Very High Very High Very High
Dextromethorphan 1 96.60 Very High Very High Very High
depression 74 91.32 High High
Dopamine 8 87.32 High High
Serotonin 15 86.80 High High
Antiepileptic agent 1 75.00 Quite High
nMDA receptor antagonist 6 73.48 Quite High
dexamethasone 1 54.88 Quite High
peripheral neuropathy 1 52.96 Quite High
fluoxetine 4 51.68 Quite High
Disease Link Frequency Relevance Heat
Infection 14 100.00 Very High Very High Very High
Hepatotoxicity 21 99.52 Very High Very High Very High
Colon Cancer 6 97.16 Very High Very High Very High
Renal Disease 4 96.16 Very High Very High Very High
Disorders Of Creatine Metabolism 4 92.52 High High
Hyperlipidemia 35 91.36 High High
Depression 59 91.32 High High
Hepatocellular Cancer 7 90.60 High High
Diabetes Mellitus 37 80.16 Quite High
Post-partum Depression 30 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, an adenovirus vector expressing CYP3A4 (AdCYP3A4) was constructed.
Gene_expression (expressing) of AdCYP3A4
1) Confidence 0.56 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.42 Pain Relevance 0
These results suggest that this cell-based assay system expressing CYP3A4 with GCSh knockdown would be useful for the prediction of CYP3A4-mediated cytotoxicity in preclinical drug development.
Gene_expression (expressing) of CYP3A4
2) Confidence 0.56 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.35 Pain Relevance 0.09
In this study, an adenovirus vector expressing CYP3A4 (AdCYP3A4) was constructed.
Gene_expression (expressing) of CYP3A4
3) Confidence 0.56 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.42 Pain Relevance 0
Three days infection of AdGCSh-shRNA and AdCYP3A4 simultaneously with H4IIE cells decreased the intracellular GSH level by 50-60% without affecting the expression level of CYP3A4.
Gene_expression (expression) of CYP3A4 associated with infection
4) Confidence 0.56 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.50 Pain Relevance 0.09
As a result, troglitazone, flutamide, and acetaminophen caused significant decreases of cell viability in AdCYP3A4/AdGCSh-shRNA group compared to the other groups (AdGFP, AdCYP3A4, AdGFP/AdGCSh-shRNA groups), indicating that reactive metabolite(s) produced by CYP3A4 and subsequently conjugated by GSH would be involved in the cytotoxicity.
Gene_expression (groups) of AdCYP3A4 associated with paracetamol
5) Confidence 0.49 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.44 Pain Relevance 0.10
Three days infection of AdGCSh-shRNA and AdCYP3A4 simultaneously with H4IIE cells decreased the intracellular GSH level by 50-60% without affecting the expression level of CYP3A4.
Gene_expression (infection) of AdCYP3A4 associated with infection
6) Confidence 0.49 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19958826 Disease Relevance 0.51 Pain Relevance 0.08
C-DNA baculovirus expressed CYP3A4 and Caco-2 cells were used for inhibitory assays, and as positive control inhibitors ketoconazole and verapamil were applied, respectively.
Gene_expression (expressed) of CYP3A4 in Caco-2
7) Confidence 0.47 Published 2010 Journal Planta Med. Section Abstract Doc Link 19790032 Disease Relevance 0 Pain Relevance 0.05
An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells.
Gene_expression (expressing) of CYP3A4 associated with hepatotoxicity
8) Confidence 0.44 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 19958826 Disease Relevance 0.50 Pain Relevance 0.06
Fatty acid composition of dietary fat, primarily the levels of omega-3 and omega-6 polyunsaturated fatty acids, has shown profound effect on colon tumor development in animal studies.
Gene_expression (levels) of omega-3 in colon associated with colon cancer
9) Confidence 0.23 Published 2005 Journal Nutr Cancer Section Abstract Doc Link 15749630 Disease Relevance 0.31 Pain Relevance 0
The following specific assays were investigated: testosterone 6beta-hydroxylation [cytochrome P-450 3A4 (CYP3A4)], coumarin hydroxylation (CYP2A6), (R)-warfarin hydroxylation (CYP1A2), (S)-mephenytoin hydroxylation (CYP2C19), p-nitrophenol hydroxylation (CYP2E1) tolbutamide hydroxylation (CYP2C9), dextromethorphan O-demethylation (CYP2D6), epoxide hydrolase and UDP-glucuronyltransferase (UGT) toward paracetamol (UGT1*6), ethinyloestradiol (UGT1*1), p-nitrophenol (UGT(pl 6.2)), and valproic acid.
Gene_expression (hydroxylation) of cytochrome P-450 3A4 associated with paracetamol and dextromethorphan
10) Confidence 0.13 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 9929511 Disease Relevance 0 Pain Relevance 0.21
The n-3 and n-6 (or omega-3 and omega-6) families of PUFAs are synthesized from the nutritionally essential fatty acids, ?
Gene_expression (synthesized) of omega-3
11) Confidence 0.04 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.45 Pain Relevance 0.31
In this regard, the prescription Lovaza (Pronova BioPharma, Lysaker, Norway) of omega-3 ethyl ester concentrate, a rich source of omega-3 fatty acid (840 mg/1-g capsules), can prove very efficacious in lowering triglycerides [7].
Gene_expression (source) of omega-3 in capsules
12) Confidence 0.04 Published 2010 Journal Curr Diab Rep Section Body Doc Link PMC2890983 Disease Relevance 0.91 Pain Relevance 0.08
Studies have shown that memantine produces minimal inhibition of CYP450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, indicating that no pharmacokinetic interactions with drugs metabolized by these enzymes are expected.
Gene_expression (produces) of CYP3A4
13) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.18 Pain Relevance 0.03
Memantine does not induce the cytochrome P450 isozymes CYP1A2, CYP2C9, CYP2E1, and CYP3A4/5 (Forest Laboratories 2003).
Gene_expression (isozymes) of CYP3A4
14) Confidence 0.00 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.19 Pain Relevance 0.04

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