INT79784

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 17.43
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (RET) signal transduction (RET) plasma membrane (RET)
Anatomy Link Frequency
lymph node 1
germline 1
lung 1
RET (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 13 97.20 Very High Very High Very High
imagery 57 96.16 Very High Very High Very High
metalloproteinase 16 95.40 Very High Very High Very High
Catecholamine 104 86.68 High High
palliative 22 78.48 Quite High
Glutamate 4 69.28 Quite High
Dopamine 12 40.48 Quite Low
Somatostatin 4 37.08 Quite Low
fifth nerve 1 34.16 Quite Low
Pain 15 32.72 Quite Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 1263 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 200 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia 30 100.00 Very High Very High Very High
Pheochromocytoma 225 99.96 Very High Very High Very High
Paraganglioma 144 99.76 Very High Very High Very High
Disease 350 99.20 Very High Very High Very High
Lung Cancer 13 99.14 Very High Very High Very High
Carcinoma 149 99.12 Very High Very High Very High
Hereditary Neoplastic Syndromes 4 98.80 Very High Very High Very High
Congenital Anomalies 12 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cumulative result of the point mutations associated with MEN 2A and 2B and FMTC and the chromosomal rearrangements associated with PTC is activation of the RET receptor tyrosine kinase (RTK).
Positive_regulation (activation) of RET receptor tyrosine kinase associated with multiple endocrine neoplasia type 2a and thyroid neoplasm
1) Confidence 0.57 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.05 Pain Relevance 0.10
Likewise, mutations that activate RET activity can lead to several hereditary cancer syndromes, including MEN types 2A and 2B and FMTC.
Positive_regulation (activate) of RET associated with multiple endocrine neoplasia and hereditary neoplastic syndromes
2) Confidence 0.57 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.53 Pain Relevance 0.04
Family studies showed that those who could not taste PTC/PROP (nontasters) carried two recessive alleles.
Neg (not) Positive_regulation (taste) of PTC
3) Confidence 0.49 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9929686 Disease Relevance 0.15 Pain Relevance 0
The constitutive activation of RET by germ-line (in MEN-2) or somatic (in a minority of sporadic PH) mutations activates various signaling pathways involved in the development of human neuroendocrine tumors including PH [8].
Positive_regulation (activation) of RET associated with neuroendocrine cancer and pheochromocytoma
4) Confidence 0.44 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.66 Pain Relevance 0.06
[A case of multiple endocrine neoplasia type 2A (MEN2A) with a mutation in the RET gene].
Positive_regulation (multiple) of MEN2A associated with multiple endocrine neoplasia type 2a and multiple endocrine neoplasia
5) Confidence 0.44 Published 1999 Journal Hinyokika Kiyo Section Title Doc Link 10442282 Disease Relevance 0.78 Pain Relevance 0.15
The major genomic abnormalities detected in the lung tumor sample were the up-regulation of the MAPK pathways through RET over-expression and PTEN deletion.
Positive_regulation (pathways) of RET in lung associated with lung cancer and congenital anomalies
6) Confidence 0.43 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.73 Pain Relevance 0
RET is a transmembrane protein that can be activated by extracellular signals and initiate a complex cascade of intracellular reactions regulating cell growth.
Positive_regulation (activated) of RET
7) Confidence 0.39 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 0.74 Pain Relevance 0
The constitutive activation of RET by germ-line (in MEN-2) or somatic (in a minority of sporadic PH) mutations activates various signaling pathways involved in the development of human neuroendocrine tumors including PH [8].
Positive_regulation (activation) of MEN-2 associated with neuroendocrine cancer and pheochromocytoma
8) Confidence 0.38 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 1.67 Pain Relevance 0.06
Prior to 2000, three different familial and syndromic diseases were known to result in PGL and/or PH: MEN-2 induced by germline inactivating mutations in the RET proto-oncogene; VHL disease due to mutations in the tumor suppressor gene VHL; and NF1 caused by mutations in the NF1 gene.
Positive_regulation (induced) of MEN-2 in germline associated with cancer, paraganglioma, watson syndrome, disease and pheochromocytoma
9) Confidence 0.38 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.42 Pain Relevance 0.08
Inhibitors of the activated RET proto-oncogene and other RTK inhibitors appear particularly promising, based on the high prevalence of mutated oncogenes and specific expression patterns in MTC [2].
Positive_regulation (activated) of RET associated with thyroid neoplasm
10) Confidence 0.38 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.79 Pain Relevance 0
However, little is known at present about the mechanisms of RET activation by mutations in the tyrosine kinase domains.
Positive_regulation (activation) of RET
11) Confidence 0.37 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.90 Pain Relevance 0
When triggered by its ligand, wild type RET receptors are induced to dimerize and this dimerization activates RET kinase activity and signal transduction [22].
Positive_regulation (activates) of RET
12) Confidence 0.37 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.78 Pain Relevance 0
When triggered by its ligand, wild type RET receptors are induced to dimerize and this dimerization activates RET kinase activity and signal transduction [22].
Positive_regulation (induced) of RET
13) Confidence 0.37 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.89 Pain Relevance 0
BRAF mutations in PTC
Positive_regulation (mutations) of PTC associated with thyroid neoplasm
14) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.90 Pain Relevance 0.23
In a retrospective cohort study of nearly 450 patients, Sywak et al have demonstrated that, in PTC, the addition of routine central lymph node dissection (CLND) results in lower postablation thyro-globulin levels and potentially reduces recurrent or persistent disease and avoids reoperative surgery.
Positive_regulation (results) of PTC in lymph node associated with thyroid neoplasm and disease
15) Confidence 0.33 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.97 Pain Relevance 0
PTC is derived from the follicular cells.
Positive_regulation (derived) of PTC associated with thyroid neoplasm
16) Confidence 0.32 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.49 Pain Relevance 0

General Comments

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