INT79787

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.88
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
muscle 2
cortex 2
muscle cell 1
uterine 1
actin (Caenorhabditis elegans)
Pain Term Frequency Confidence Heat
Angina 4 92.32 High High
Dismenorea 3 85.20 High High
withdrawal 6 67.92 Quite High
cytokine 7 63.76 Quite High
Inflammation 12 63.36 Quite High
GABAergic 16 56.32 Quite High
gABA 14 53.04 Quite High
ischemia 7 49.84 Quite Low
cva 4 42.00 Quite Low
fibrosis 3 40.80 Quite Low
Disease Term Frequency Confidence Heat
Necrosis 9 97.24 Very High Very High Very High
Myxoma 10 94.72 High High
Cancer 60 94.64 High High
Pressure And Volume Under Development 11 93.44 High High
Increased Venous Pressure Under Development 30 93.20 High High
Lung Cancer 3 92.56 High High
Cv General 3 Under Development 2 92.32 High High
Injury 41 91.68 High High
Rhabdomyolysis 100 90.76 High High
Non-small-cell Lung Cancer 2 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardiac troponin-I (cTnI), one of the subunits of the troponin regulatory complex, binds to actin and inhibits interactions between actin and myosin.
myosin Binding (interactions) of actin
1) Confidence 0.06 Published 1999 Journal Clin Cardiol Section Abstract Doc Link 9929748 Disease Relevance 0.75 Pain Relevance 0.25
Immuno-histochemistry was positive for vimentin and desmin while negative for actin and myosin.
myosin Binding (negative) of actin
2) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2535586 Disease Relevance 1.05 Pain Relevance 0
Ozaki et al. [35] also demonstrated that caffeine acted directly on the MLC kinase and on the actin and myosin interaction, slightly inhibiting MLC phosphorylation and contraction.
myosin Binding (interaction) of actin
3) Confidence 0.01 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0.09 Pain Relevance 0
Ozaki et al. [35] also demonstrated that caffeine acted directly on the MLC kinase and on the actin and myosin interaction, slightly inhibiting MLC phosphorylation and contraction.
myosin Binding (interaction) of actin
4) Confidence 0.01 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0.09 Pain Relevance 0
Production of IP3 may further induce influx of calcium (Ca2+) from the extracellular space through voltage gated channels.70 Activated myosin light chain kinase, under the influence of released intracellular calcium – calmodulin complexes, causes phosphorylation of myosin which then interacts with actin to cause uterine contraction.
myosin Binding (interacts) of actin in uterine
5) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.21 Pain Relevance 0.18
The excess of calcium causes a pathologic interaction of actin and myosin, and activates cellular proteases with muscle destruction and fiber necrosis [51].
myosin Binding (interaction) of actin in muscle associated with necrosis
6) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 2.18 Pain Relevance 0
As regards cardiac troponins T, I and C, they regulate muscle contraction by modulating calcium-dependent interaction of actin and myosin.
myosin Binding (interaction) of actin in muscle
7) Confidence 0.01 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0 Pain Relevance 0
For example, one additional link between calcium signalling and cytoskeletal dynamics comes from a recent microarray screen, which has found that the calcium sensor cardiac troponin C (part of a complex that mediates calcium-dependent actin–myosin interaction) is elevated in visual cortex during the critical period, and is regulated by visual activity (Lyckman et al. 2008).
myosin Binding (interaction) of actin in cortex
8) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0 Pain Relevance 0.05
For example, one additional link between calcium signalling and cytoskeletal dynamics comes from a recent microarray screen, which has found that the calcium sensor cardiac troponin C (part of a complex that mediates calcium-dependent actin–myosin interaction) is elevated in visual cortex during the critical period, and is regulated by visual activity (Lyckman et al. 2008).
myosin Binding (interaction) of actin in cortex
9) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0 Pain Relevance 0.05
MLCK is responsible for smooth muscle cell and non-muscle cell migration via phosphorylation of Ser19 and Thr18 on myosin light chains (MLC), which could facilitate myosin interaction with actin filaments[23,24].
myosin Binding (interaction) of actin in muscle cell
10) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 1.50 Pain Relevance 0

General Comments

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