INT79797

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.12
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPC3) transmembrane transport (TRPC3)
TRPC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
vanilloid receptor subtype 1 2 98.28 Very High Very High Very High
Neurotransmitter 2 97.00 Very High Very High Very High
agonist 9 91.00 High High
cytokine 8 84.48 Quite High
member 8 1 71.76 Quite High
Inflammation 23 60.04 Quite High
Inflammatory mediators 4 50.24 Quite High
antagonist 4 36.60 Quite Low
Calcium channel 1 27.44 Quite Low
imagery 2 6.16 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 60.04 Quite High
Targeted Disruption 6 38.08 Quite Low
Adhesions 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Neutrophil Disorders 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Prostate Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have demonstrated a significant increase in TRPC3, 4 and 6 protein in myometrial tissue from women in labour and have subsequently investigated potential stimuli responsible for inducing such changes [26].
Positive_regulation (increase) of TRPC3
1) Confidence 0.38 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892065 Disease Relevance 0.12 Pain Relevance 0.34
As it has been demonstrated that diacylglycerol analogs cannot activate TRPC3 and TRPC6 channels through stimulation of PKC, diacylglycerol could itself regulate TRPC3 and TRPC6 directly [91].
Positive_regulation (activate) of TRPC3
2) Confidence 0.29 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
More precisely, it is generally accepted that TRPC1, TRPC4, and TRPC5 are activated by Ca2+ store depletion [55565758596061], and TRPC3, TRPC6, and TRPC7 are directly activated by diacylglycerol and its cell-permeant analogs in an InsP3-R-independent manner [6263646566].
Positive_regulation (activated) of TRPC3
3) Confidence 0.27 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
Positive_regulation (activation) of TRPC3
4) Confidence 0.21 Published 1999 Journal Nature Section Title Doc Link 9930701 Disease Relevance 0 Pain Relevance 0.11
Although hTRPC3, the closest structural relative of hTRPC6, is activated in the same way, TRPCs 1, 4 and 5 and the vanilloid receptor subtype 1 are unresponsive to the lipid mediator.
Positive_regulation (activated) of hTRPC3 associated with vanilloid receptor subtype 1
5) Confidence 0.19 Published 1999 Journal Nature Section Abstract Doc Link 9930701 Disease Relevance 0 Pain Relevance 0.13

General Comments

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