INT7980

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 13.37
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Fut4) Golgi apparatus (Fut4)
Anatomy Link Frequency
dendritic cells 3
ventricle 1
dorsal 1
cap cells 1
spinal cord 1
Fut4 (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 14 99.40 Very High Very High Very High
Raphe 7 99.40 Very High Very High Very High
Dorsal horn 14 99.36 Very High Very High Very High
Osteoarthritis 8 98.80 Very High Very High Very High
Spinal cord 27 98.12 Very High Very High Very High
dorsal root ganglion 24 97.24 Very High Very High Very High
c fibre 7 96.64 Very High Very High Very High
Pain 11 94.12 High High
headache 1 92.36 High High
nociceptor 8 91.60 High High
Disease Link Frequency Relevance Heat
Infection 188 99.96 Very High Very High Very High
Epstein-barr Virus 4 99.80 Very High Very High Very High
Sprains And Strains 418 99.68 Very High Very High Very High
Pancreatic Cancer 9 99.64 Very High Very High Very High
Disease 188 99.04 Very High Very High Very High
Osteoarthritis 8 98.80 Very High Very High Very High
Cancer 30 98.12 Very High Very High Very High
Frailty 352 97.76 Very High Very High Very High
Ganglion Cysts 24 97.24 Very High Very High Very High
Arthralgia 11 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This localization indicated that SSEA-1 is present in proliferating premigratory cells of the rat spinal cord.
Gene_expression (present) of SSEA-1 in spinal cord associated with spinal cord
1) Confidence 0.62 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.21
A embryonal day 9 (E9), SSEA-1 was detected in the neural ectoderm and, at E11, in cells near the ventricle of the matrix layer.
Gene_expression (detected) of SSEA-1 in ventricle
2) Confidence 0.62 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.19
These distribution patterns indicated that SSEA-1 is present on migratory and/or postmigratory cells.
Gene_expression (present) of SSEA-1
3) Confidence 0.62 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.40
SSEA-1 was first present in Rexed's laminae II, IV and V.
Gene_expression (present) of SSEA-1
4) Confidence 0.54 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.39
Between E12 and E16, cells of the alar plate expressed SSEA-1.
Gene_expression (expressed) of SSEA-1 in alar plate
5) Confidence 0.54 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.21
After birth, SSEA-1 was present throughout the dorsal horn, probably as a result of the myelination of the fibres.
Gene_expression (present) of SSEA-1 in dorsal horn associated with dorsal horn
6) Confidence 0.48 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.38
From E16 on, SSEA-1 was present in the dorsal raphe, which suggested a function for SSEA-1 in the guidance of developing fibres.
Gene_expression (present) of SSEA-1 in dorsal associated with raphe
7) Confidence 0.42 Published 1992 Journal Histochem. J. Section Abstract Doc Link 1362198 Disease Relevance 0 Pain Relevance 0.34
In addition, expression of SSEA-1, an ESC-specific antigen[29], [30] was absent on E-RoSH2.1 cells (fig. 4a, b).
Neg (absent) Gene_expression (expression) of SSEA-1
8) Confidence 0.16 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
Thus, Lex and Ley were expressed in stomachs with a lower gastric pH (pH 2–5) and Ley in stomachs with at a neutral pH.
Gene_expression (expressed) of Lex in stomachs
9) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.40 Pain Relevance 0
Interestingly, expression of Lex and Ley has been shown to be influenced by pH and iron levels in vitro [25], [26] and vary in different gastric regions and within a single host [22].
Gene_expression (expression) of Lex
10) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.39 Pain Relevance 0
To test if putative RoSH cells in adherent monolayer culture generated by plating 5 day EBs could be isolated using CD9 and SSEA-1 as selectable markers, the heterogenous differentiating EB culture was sorted for CD9hi, SSEA1?
Gene_expression (using) of SSEA-1
11) Confidence 0.14 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
Even though there is a considerable intra-individual variability, it appears that there is a selection for maintaining the fucosyltransferase genes on so that both Lex and/or Ley are expressed.
Gene_expression (expressed) of Lex
12) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.29 Pain Relevance 0
In contrast, least common was Lex expression exclusively, which was found in 8.5% of the 482 clinical isolates (Table 2, Figures 3 and S1), suggesting a selection for maintaining futC in- frame.
Gene_expression (expression) of Lex
13) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.29 Pain Relevance 0
Thus, there were very few isolates, 41 out of 482 single-colony isolates (8.5%) that did not express Lex or Ley, which are the most commonly found Lewis antigens in H. pylori LPS.
Neg (not) Gene_expression (express) of Lex
14) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.30 Pain Relevance 0
The original HPAG1 isolate, used for mouse infection, produced Ley, and no Lex, arguing that the futC gene must be expressed.
Neg (no) Gene_expression (produced) of Lex associated with infection
15) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.43 Pain Relevance 0
Overall, the majority of isolates, 91%, expressed both Lex and Ley simultaneously or alone.
Gene_expression (expressed) of Lex
16) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.29 Pain Relevance 0
However, four of the five isolates from the wildtype mice had switched Lewis antigen phenotype and expressed O-antigen chains that were both Lex- and Ley-glycosylated (Figure 1), while four of five isolates from the tox176 mice expressed O-antigen chains that were exclusively Ley-glycosylated (like the infecting HPAG1 strain).
Gene_expression (expressed) of Lex associated with sprains and strains
17) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.61 Pain Relevance 0
Based on the expression pattern of CD9 and SSEA-1, flow cytometry readily resolved a 1:10 mixture of E-RoSH2.1 cells and E14 ESCs into two distinct populations, CD9hi, SSEA1?
Gene_expression (expression) of SSEA-1
18) Confidence 0.13 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
Isolates from each individual were divided into four phenotype groups depending on the Lewis antigens expressed; (1) isolates expressing both Lex and Ley, (2) isolates expressing only Lex, (3) isolates expressing only Ley, and (4) isolates with expression of neither Lex nor Ley (Table 2 and Figure 4).
Gene_expression (expression) of Lex
19) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.28 Pain Relevance 0
Notably, we observed a non-significant trend towards higher frequencies of simultaneous expression of Lex and Ley among H. pylori isolates from individuals with atrophy as compared to normal individuals (T-test, P?
Gene_expression (expression) of Lex associated with frailty
20) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox