INT79803

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Context Info
Confidence 0.02
First Reported 1999
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (PCDHB17) plasma membrane (PCDHB17)
Anatomy Link Frequency
plasma 1
C cells 1
PCDHB17 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 24 100.00 Very High Very High Very High
mu opioid receptor 5 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Opioid 7 97.32 Very High Very High Very High
agonist 4 86.64 High High
opioid receptor 8 86.52 High High
Delta opioid receptors 1 85.60 High High
Antinociceptive 1 81.24 Quite High
Hyperalgesia 1 79.36 Quite High
analgesia 1 78.68 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 4 99.36 Very High Very High Very High
Hyperalgesia 1 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[D-Ala2,N-Me-Phe4,Gly-ol]enkephalin (DAMGO)-induced PKC translocation follows a time-dependent and biphasic pattern beginning 2 h after opioid addition, when a pronounced translocation of PKC to the plasma membrane occurs.
Localization (translocation) of N-Me-Phe4 in plasma associated with kinase c, enkephalin and opioid
1) Confidence 0.02 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.46
Unlike OFQ/N-mediated desensitization of ORL1 and mu-opioid receptors, [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO)-mediated ORL1 desensitization in BE(2)-C cells is PKC-independent.
Localization (desensitization) of N-Me-Phe4 in C cells associated with mu opioid receptor and enkephalin
2) Confidence 0.02 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.23 Pain Relevance 0.83

General Comments

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