INT79805

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Context Info
Confidence 0.81
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 57
Total Number 64
Disease Relevance 23.33
Pain Relevance 20.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
neurons 14
neuronal 7
plasma 1
tail 1
platelets 1
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2430 100.00 Very High Very High Very High
bradykinin 127 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
agonist 1223 99.82 Very High Very High Very High
Delta opioid receptors 5 99.52 Very High Very High Very High
Calcium channel 103 98.54 Very High Very High Very High
5HT 141 98.44 Very High Very High Very High
adenocard 71 97.84 Very High Very High Very High
sodium channel 84 97.44 Very High Very High Very High
Neuronal excitability 65 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Virus Diseases 2848 100.00 Very High Very High Very High
Rabies Virus Infection 32 99.80 Very High Very High Very High
Infection 949 99.42 Very High Very High Very High
Down Syndrome 16 98.92 Very High Very High Very High
Disease 445 98.32 Very High Very High Very High
Borna Disease 128 93.68 High High
Injury 31 91.68 High High
Neurological Disease 128 87.64 High High
Prostate Cancer 1 87.16 High High
Hyperalgesia 11 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase C (PKC) has been shown to catalyze the in vitro phosphorylation of mu- and delta-opioid receptors and to potentiate agonist-induced receptor desensitization.
Phosphorylation (phosphorylation) of PKC associated with kinase c, agonist and delta opioid receptors
1) Confidence 0.81 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.07 Pain Relevance 0.96
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Phosphorylation (opened) of PKC associated with kinase c
2) Confidence 0.69 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
1-adrenoreceptors) mitoKATP channels are opened via Gi proteins and PKC, possibly PKC-?
Phosphorylation (opened) of PKC associated with kinase c
3) Confidence 0.69 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.32
Many UDP-glucuronosyltransferases (UGTs) require phosphorylation by protein kinase C (PKC) for glucuronidation activity.
Phosphorylation (phosphorylation) of PKC associated with kinase c
4) Confidence 0.61 Published 2010 Journal Xenobiotica Section Abstract Doc Link 20196639 Disease Relevance 0 Pain Relevance 0.57
Indeed, phosphorylation of MARCKS by PKC is implicated in actin-dependent cytoskeletal plasticity [44] and in the maintenance of long-term potentiation in vivo [45].
Phosphorylation (phosphorylation) of PKC associated with kinase c and long-term potentiation
5) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.35 Pain Relevance 0.22
These findings suggest that PKC-dependent phosphorylation of P is an important parameter for efficient transmission of BDV from neuron to neuron.
Phosphorylation (phosphorylation) of PKC-dependent in neuron associated with virus diseases and kinase c
6) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.48 Pain Relevance 0.32
Indeed, PKC phosphorylation of SNAP-25, by promoting inhibition of VGCCs decreases calcium signaling and controls neuronal excitability.
Phosphorylation (phosphorylation) of PKC in neuronal associated with kinase c and neuronal excitability
7) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.06 Pain Relevance 0.31
Infection with the rBDV-AASS virus led to a complete restoration of the PKC-dependent phosphorylation of two neuronal targets that play crucial roles in modulating neuronal plasticity.
Phosphorylation (phosphorylation) of PKC-dependent in neuronal associated with kinase c and infection
8) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.36 Pain Relevance 0.20
Consistent with our previous reports, we showed by quantitative Western blot analysis that the phosphorylation of these two neuronal PKC targets was significantly impaired in neurons infected with rBDV-wt (Figure 2A and 2B).
Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c
9) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.30 Pain Relevance 0.33
Recently, we have shown that BDV-induced impairment of potentiation of synaptic activity was due to an interference with the PKC-dependent phosphorylation of synaptic proteins that modulate neuronal activity [24].
Phosphorylation (phosphorylation) of PKC-dependent in neuronal associated with virus diseases and kinase c
10) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.48 Pain Relevance 0.25
Moreover, neurons infected with this mutant virus exhibited a normal pattern of phosphorylation of the PKC endogenous substrates MARCKS and SNAP-25.
Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c
11) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.50
In theory, other viral phosphoproteins could also block endogenous phosphorylation, including that of PKC.
Phosphorylation (phosphorylation) of PKC associated with kinase c
12) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.86 Pain Relevance 0.27
Therefore, preventing P phosphorylation by PKC abolishes viral interference with neuronal activity in response to stimulation.
Phosphorylation (phosphorylation) of PKC in neuronal associated with kinase c
13) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.53 Pain Relevance 0.46
Together, these findings suggest that BDV mediated interference with PKC-dependent phosphorylation, by reducing phospho-SNAP-25 levels, leads to calcium hyper-responsiveness and that mutation of the BDV P phosphorylation sites restores normal calcium responses.


Phosphorylation (phosphorylation) of PKC-dependent associated with virus diseases and kinase c
14) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.28 Pain Relevance 0.19
By using a recombinant BDV with mutated PKC phosphorylation site on P, we demonstrate the central role of this protein in BDV pathogenesis.
Phosphorylation (phosphorylation) of PKC associated with virus diseases and kinase c
15) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.97 Pain Relevance 0.47
Thus, a possible interference with PKC-dependent phosphorylation in neurons becomes apparent following BDV infection due to its outstanding non-cytolytic replication strategy, whereas it would not be detected with other viral systems that kill their target cell within a few days.
Phosphorylation (phosphorylation) of PKC-dependent in neurons associated with virus diseases, kinase c and infection
16) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.71 Pain Relevance 0.24
Moreover, the selective impairment of neuronal plasticity due to BDV infection was correlated to a reduced phosphorylation of the neuronal targets of Protein Kinase C (PKC), a kinase that plays important roles in the regulation of neuronal activity [25].
Phosphorylation (phosphorylation) of PKC in neuronal associated with virus diseases, kinase c and infection
17) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 1.54 Pain Relevance 0.31
For example, it has been shown that rabies P can be phosphorylated by PKC [50].
Phosphorylation (phosphorylated) of PKC associated with kinase c and rabies virus infection
18) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.86 Pain Relevance 0.27
Thus, the phenotype observed with rBDV-LLSS is very similar to rBDV-AASS, providing additional evidence that our findings are indeed due to phosphorylation of BDV-P by PKC and not to the mutations present in X.
Phosphorylation (phosphorylation) of PKC associated with virus diseases and kinase c
19) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.53 Pain Relevance 0.09
We first showed that the kinetics of dissemination of this recombinant virus was strongly delayed, suggesting that phosphorylation of P by PKC is required for optimal viral spread in neurons.
Phosphorylation (phosphorylation) of PKC in neurons associated with kinase c
20) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.89 Pain Relevance 0.48

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