INT79815

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.07
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 4
aorta 2
bowel 2
lung 2
vas deferens 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 51 100.00 Very High Very High Very High
antagonist 14 99.86 Very High Very High Very High
Neurotransmitter 2 99.84 Very High Very High Very High
Neuropeptide 5 96.52 Very High Very High Very High
algogenic 4 94.92 High High
Calcitonin gene-related peptide 4 94.32 High High
dorsal root ganglion 22 89.60 High High
Somatostatin 1 89.04 High High
substance P 1 87.92 High High
Inflammation 5 85.32 High High
Disease Link Frequency Relevance Heat
Intestinal Obstruction 2 99.88 Very High Very High Very High
Diabetes Mellitus 132 98.92 Very High Very High Very High
Hyperglycemia 7 90.00 High High
Ganglion Cysts 23 89.60 High High
Hypertension 8 89.12 High High
INFLAMMATION 6 85.32 High High
Nociception 7 80.32 Quite High
Adult Respiratory Distress Syndrome 14 70.80 Quite High
Renal Disease 8 60.12 Quite High
Sepsis 4 58.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As suggested by recent investigators, competition at the receptor between ET-1 and its antagonists could result in release of ET-1 from the receptor, thereby contributing to an overall increase in the plasma concentration consistent with the present findings [43].
Positive_regulation (result) of Localization (release) of ET-1 in plasma associated with antagonist
1) Confidence 0.68 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.25 Pain Relevance 0.05
They suggested that increased release of ET-1 from the aorta contributes to enhanced plasma level of ET-1 seen in diabetic rats.
Positive_regulation (increased) of Localization (release) of ET-1 in aorta associated with diabetes mellitus
2) Confidence 0.60 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.11 Pain Relevance 0.03
These data suggest that, despite the absence of ETB receptor-mediated plasma clearance of ET-1, neither the venous peptide content nor the net release of ET-1 is increased in the splanchnic vasculature of DOCA-salt rats.
Positive_regulation (increased) of Localization (release) of ET-1 in plasma
3) Confidence 0.50 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15471983 Disease Relevance 0.21 Pain Relevance 0
CONCLUSION: Bupivacaine and ropivacaine attenuated N-formyl-L-leucine-methionyl-L-phenylalanine-induced PAP, reduced lung edema, and diminished ET-1 release.
Positive_regulation (induced) of Localization (release) of ET-1 in lung
4) Confidence 0.47 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0
This suggestion is supported by a recent study on mouse DRGs which showed that the Ca2+ release in response to ET-1, and the potentiatory effect of ET-1 on capsaicin-induced Ca2+ responses are mediated exclusively by ETARs [19].
Positive_regulation (mediated) of Localization (release) of ET-1 associated with qutenza
5) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.30 Pain Relevance 0.66
We have investigated the neuromodulatory effects of endothelin-1 on capsaicin-induced release of neurotransmitters from rat vas deferens.
Spec (investigated) Positive_regulation (capsaicin-induced) of Localization (release) of endothelin-1 in vas deferens associated with neurotransmitter and qutenza
6) Confidence 0.39 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9932722 Disease Relevance 0 Pain Relevance 0.94
In the present study tissue endothelin levels were not assayed but in experimental strangulated small bowel obstructions, the release and concentration of ET-1 has been shown to increased in the venous blood of strangulated intestinal loop.
Positive_regulation (increased) of Localization (release) of ET-1 in bowel associated with intestinal obstruction
7) Confidence 0.26 Published 2006 Journal World J Emerg Surg Section Body Doc Link PMC1764411 Disease Relevance 0.19 Pain Relevance 0.11
RESULTS: Pretreatment with LAs significantly reduced the FMLP-induced PAP increase (treatment group v sham group: 0.5 to 5 mm Hg v 8 mm Hg; P < .05) and the release of endothelin-1 (2.4 v 5 fmol/mL).
Positive_regulation (increase) of Localization (release) of endothelin-1
8) Confidence 0.15 Published 2006 Journal Reg Anesth Pain Med Section Body Doc Link 16701192 Disease Relevance 0 Pain Relevance 0

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