INT79822

Context Info Confidence 0.65 First Reported 1999 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 2.92 Pain Relevance 6.27

plasma membrane (Htr1b) cytoplasm (Htr1b) signal transducer activity (Htr1b)

Anatomy Link Frequency nerve 1 neurons 1 midbrain 1 Htr1b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Catechol-O-methyltransferase 5 100.00 antagonist 67 99.96 agonist 67 99.96 Triptan 39 99.64 Dopamine 102 99.58 Raphe 15 99.40 sSRI 17 98.60 Periaqueductal grey 220 98.50 Trigeminal ganglion neurons 4 98.50 Serotonin 30 98.24

Disease Link Frequency Relevance Heat Attention Deficit Hyperactivity Disorder 304 100.00 Urological Neuroanatomy 220 98.50 Ganglion Cysts 5 98.34 Migraine Without Aura 2 97.24 Headache 45 94.00 Cluster Headache 2 92.96 Depression 11 91.88 Pain 37 88.00 Stress 11 87.64 Syndrome 29 84.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results indicate that in rat striatal axon terminals the K(+)-evoked release of dopamine is regulated by the presynaptic 5-HT1B heteroreceptors.

Gene_expression (presynaptic) of 5-HT1B associated with dopamine

1) Confidence 0.65 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9933149 Disease Relevance 0 Pain Relevance 0.43

The 5-HT1B selective agonist CP93129 (3 ?

Gene_expression (selective) of 5-HT1B associated with agonist

2) Confidence 0.65 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.20 Pain Relevance 0.46

M) did not produce a significant reduction in evoked IPSC amplitude in the presence of the 5-HT1B antagonist NAS181 (10 ?

Gene_expression (presence) of 5-HT1B associated with antagonist

3) Confidence 0.65 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.08 Pain Relevance 0.67

Clinical data suggest that coadministration of pindolol, a 5-HT1A/5-HT1B/beta-adrenoceptor antagonist, and selective serotonin reuptake inhibitors (SSRIs) may shorten the time of onset of a clinical action and may increase beneficial effects of the therapy of drug-resistant depression.

Gene_expression (coadministration) of 5-HT1B associated with depression, antagonist and ssri

4) Confidence 0.65 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866716 Disease Relevance 0.09 Pain Relevance 0.44

However, when constructed in the presence of WAY 100635 (10 nM) the selective and silent 5-HT1A antagonist, there was a significant (P < 0.001) rightward shift of the CP 93129 concentration-response curve in the paroxetine-treated rats but not in the controls, implying a desensitisation of the 5-HT1B autoreceptor by paroxetine.

Gene_expression (desensitisation) of 5-HT1B associated with antagonist

5) Confidence 0.65 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10676872 Disease Relevance 0 Pain Relevance 0.38

The PAG contains a dense plexus of serotonergic nerve terminals [20], and varying levels of 5-HT1A, 5-HT1B, 5-HT1D and 5-HT1F receptor mRNA and protein has been found in different species [21-25].

Gene_expression (levels) of 5-HT1B in nerve associated with periaqueductal grey

6) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.82 Pain Relevance 1.39

It is also consistent with prior studies which have reported that 5-HT1A levels within the PAG are relatively low compared to the adjacent dorsal raphe nucleus, and that 5-HT1A and 5-HT1B receptors are largely expressed within postsynaptic and presynaptic elements within the midbrain, respectively [43,44].

Gene_expression (expressed) of 5-HT1B in midbrain associated with periaqueductal grey, midbrain and raphe

7) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.35 Pain Relevance 0.91

In this regard, the extant evidence tends to support the novel concept of an adjunctive polypharmacy approach for the prevention and treatment of ADHD rather than single neurochemical and/or neurogenetic targets (eg, D1-D5, DAT1, DBH, COMT, 5HT1B, NR4A2, SLC1A3, BDNF, as well as loci at 4q13.2, 5q33.3, 11q22 and 17p11 [see above]).

Neg (prevention) Gene_expression (prevention) of 5HT1B associated with catechol-o-methyltransferase and attention deficit hyperactivity disorder

8) Confidence 0.24 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.58 Pain Relevance 0.05

Approximately 46% of the 5-HT1B-positive and 43% of the 5-HT1D-positive trigeminal ganglion neurons were also NF200 positive, indicating that many A-fibre trigeminal neurons express 5-HT1B or 5-HT1D receptors.

Gene_expression (express) of 5-HT1B in neurons associated with ganglion cysts and trigeminal ganglion neurons

9) Confidence 0.14 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422450 Disease Relevance 0.52 Pain Relevance 1.13

These genetic differences could be explained by various genes, the HTR1B, encoding the 5-HT(1) receptor subtype, MAOA gene that encodes the monoamino-oxidase, the main metabolic enzyme of this triptan, SLC6A4 (gene encoding the serotonin transporter) and DRD(2) (gene encoding the D(2) receptor), both involved in the pathogenesis of migraine.

Gene_expression (enzyme) of HTR1B associated with migraine, triptan and serotonin

10) Confidence 0.13 Published 2007 Journal J Headache Pain Section Abstract Doc Link 17563839 Disease Relevance 0.28 Pain Relevance 0.42

General Comments

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