INT79835

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 21.22
Pain Relevance 11.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
liver 2
macrophage 1
fat 1
alternatively activated macrophages 1
brain 1
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 577 100.00 Very High Very High Very High
cytokine 368 100.00 Very High Very High Very High
adenocard 75 99.68 Very High Very High Very High
chemokine 24 99.48 Very High Very High Very High
tolerance 32 99.24 Very High Very High Very High
fibrosis 122 98.80 Very High Very High Very High
acular 2 98.68 Very High Very High Very High
Paracetamol 14 97.52 Very High Very High Very High
Morphine 27 97.42 Very High Very High Very High
agonist 17 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 601 100.00 Very High Very High Very High
Inflammatory Bowel Disease 5 100.00 Very High Very High Very High
Mucositis 1 100.00 Very High Very High Very High
Cancer 104 99.92 Very High Very High Very High
Necrosis 24 99.68 Very High Very High Very High
Liver Disease 10 99.56 Very High Very High Very High
Sprains And Strains 69 99.52 Very High Very High Very High
Targeted Disruption 102 99.32 Very High Very High Very High
Infection 261 99.26 Very High Very High Very High
Bacterial Meningitis 12 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we assessed the role of prostaglandins in the regulation of mucosal inflammation in the IL-10(-/-) mouse model of IBD.
Regulation (regulation) of IL-10 associated with inflammatory bowel disease, mucositis and inflammation
1) Confidence 0.61 Published 2002 Journal Gastroenterology Section Abstract Doc Link 12404228 Disease Relevance 0.63 Pain Relevance 0.30
Damgo and U-50488 at the concentrations of 10(-6) and 10(-8) M decreased the production of IL-12 without affecting IL-10.
Neg (without) Regulation (affecting) of IL-10
2) Confidence 0.59 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.75
In conclusion, liver homeostasis following AILD appears to be highly dependent on the activities of both IL-10 and IL-4, which together help prevent overexpression of IL-6 and other potential hepatotoxic factors.
Regulation (dependent) of IL-10 in liver associated with liver disease
3) Confidence 0.52 Published 2007 Journal Chem. Res. Toxicol. Section Abstract Doc Link 17305405 Disease Relevance 0.88 Pain Relevance 0.54
This does not appear to be directly correlated with IL-10's regulation of DREAM, a transcriptional regulator of prodynorphin synthesis.
Regulation (regulation) of IL-10
4) Confidence 0.45 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12799032 Disease Relevance 0.67 Pain Relevance 0.33
Immunomodulation with interleukin-10 and interleukin-4 compared with ketorolac tromethamine for prevention of postoperative adhesions in a murine model.
Regulation (Immunomodulation) of interleukin-10 associated with acular and adhesions
5) Confidence 0.44 Published 1999 Journal Fertil. Steril. Section Title Doc Link 9935118 Disease Relevance 0.10 Pain Relevance 0.33
Down-regulation of Th2 cytokine genes (Il4, Il10, Il13), as described in our data, has been reported in alloreactive T cells in which tolerance has been induced and immune rejection suppressed (Taylor et al. 2002).
Regulation (regulation) of Il10 in T cells associated with tolerance and cytokine
6) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.02 Pain Relevance 0.54
Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.
Regulation (Role) of IL-10 in liver associated with targeted disruption, paracetamol and injury
7) Confidence 0.38 Published 2007 Journal Chem. Res. Toxicol. Section Title Doc Link 17305405 Disease Relevance 0.56 Pain Relevance 0.64
Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment.
Neg (unchanged) Regulation (unchanged) of IL-10 associated with necrosis, cancer and morphine
8) Confidence 0.35 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.27 Pain Relevance 1.07
In contrast, the anti-inflammatory cytokine IL-10 was similarly affected in the two strains.
Regulation (affected) of IL-10 associated with inflammation, sprains and strains and cytokine
9) Confidence 0.26 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.20 Pain Relevance 1.09
This is supported by the fact that IL-1Ra and IL-10 response after LPS exposure is decreased in Ob/Ob mice [55], although we observed higher levels of IL-1Ra and IL-10 in HFD-fed obese mice in the present study.
Regulation (response) of IL-10 associated with obesity
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.88 Pain Relevance 0
The anti-inflammatory cytokines IL-1Ra and IL-10 were both markedly up-regulated in fat and serum in HFD-fed mice on day 5–7 after bacterial challenge.
Regulation (regulated) of IL-10 in fat associated with inflammation and cytokine
11) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 1.33 Pain Relevance 0.45
In addition, IL-10 was up-regulated in silica-susceptible mice (DBA2) but reduced in a resistant strain (BALB/c) (Figure 5 C).
Regulation (regulated) of IL-10 associated with sprains and strains
12) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.63 Pain Relevance 0.49
The protective effect of rh-IL-10 administration during high-level bacteremia on cytokine production in CR3 knocked down mice was completely abrogated (Fig. 7 E, only TNF data are depicted).
Regulation (effect) of rh-IL-10 associated with bacteremia and cytokine
13) Confidence 0.22 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.26 Pain Relevance 0.05
To confirm that CR3 expression is critical in vivo for rh-IL-10 mediated protection against E. coli infection and brain damage, CR3 expression in mice was suppressed using Invivofectamine reagent.
Regulation (critical) of rh-IL-10 in brain associated with infection
14) Confidence 0.22 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.43 Pain Relevance 0
L-NAME has a higher selectivity and potency for nNOS than for eNOS and iNOS [55-58]; therefore, it might be possible that L-NAME preferentially inhibited nNOS, but not eNOS and iNOS, and thus produced the effect on IL-10, like the selective nNOS inhibitor 7-NINA.
Regulation (effect) of IL-10 associated with potency
15) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.40 Pain Relevance 0.51
However, in this study CO inhalation had no impact on lavage fluid IL-6, IL-10, or the CXC chemokines MIP-2 and KC.
Neg (no) Regulation (impact) of IL-10 associated with chemokine
16) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.34 Pain Relevance 0.22
No significant change in lung IL-10 content was noted in the saline, NI (poorly soluble particles of low toxicity, WC) or RA (inflammatory but not fibrogenic particles) groups, indicating that IL-10 induction in mice seems specific to the fibrotic process.
Neg (No) Regulation (change) of IL-10 in lung associated with fibrosis, toxicity, inflammation and rheumatoid arthritis
17) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.74 Pain Relevance 0.50
Genes promoting immune responses were down-regulated, including genes for the proinflammatory/Th2 cytokines IL-1b, IL-4, IL-6, IL-10, IL-13, and TNF-?.
Regulation (regulated) of IL-10 associated with cytokine
18) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.03 Pain Relevance 0.52
IL-10 is therefore, as previously reported, a critical regulator of peritoneal inflammation that is regulated by A2A adenosine receptors but not by A3 adenosine receptors [24,25].
Neg (not) Regulation (regulated) of IL-10 associated with adenocard and inflammation
19) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.19 Pain Relevance 1.02
Thirdly, TLR2 mediated the HSP60-stimulated the expression of Stat3-controled suppressive factors, such as IL-10, IL-13, TGF-?
Regulation (controled) of IL-10
20) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.69 Pain Relevance 0.03

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