INT79840

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Context Info
Confidence 0.16
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.51
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga2b)
Anatomy Link Frequency
platelet 2
sensory neurons 1
Itga2b (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 7 96.76 Very High Very High Very High
Mechanotransduction 1 92.64 High High
agonist 1 91.84 High High
Angina 4 89.36 High High
vincristine 2 87.20 High High
Inflammation 1 84.88 Quite High
aspirin 2 84.24 Quite High
intrathecal 1 82.00 Quite High
antagonist 2 75.00 Quite High
peripheral neuropathy 1 73.64 Quite High
Disease Link Frequency Relevance Heat
Metastasis 2 99.28 Very High Very High Very High
Adhesions 2 98.64 Very High Very High Very High
Cancer 6 98.40 Very High Very High Very High
Hyperalgesia 7 96.76 Very High Very High Very High
Disease 2 95.44 Very High Very High Very High
Cv General 3 Under Development 4 89.36 High High
Targeted Disruption 1 89.16 High High
Diabetes Mellitus 2 87.72 High High
Stroke 2 86.56 High High
Increased Venous Pressure Under Development 2 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abciximab binds with high avidity to both the non-activated and activated form of the GPIIb/IIIa receptor of platelets, the major adhesion receptor involved in aggregation.
GPIIb/IIIa Binding (binds) of in platelets associated with adhesions
1) Confidence 0.16 Published 2000 Journal Pathol. Oncol. Res. Section Abstract Doc Link 11033455 Disease Relevance 0.49 Pain Relevance 0.13
Since abciximab interacts with high avidity to integrins GPIIb/IIIa and a av b b3, it is reasonable to assume that it may possess anti-angiogenic properties in angiogenesis-related diseases, as well as anti-metastastatic properties in case of disseminating tumors expressing the target integrin receptors.
GPIIb/IIIa Binding (interacts) of associated with cancer and disease
2) Confidence 0.15 Published 2000 Journal Pathol. Oncol. Res. Section Abstract Doc Link 11033455 Disease Relevance 0.87 Pain Relevance 0.12
Since abciximab binds to the platelet GP IIb-IIIa receptor with great avidity it has an extremely long biological half-life.
GP IIb-IIIa receptor Binding (binds) of in platelet
3) Confidence 0.14 Published 1999 Journal Drug Saf Section Abstract Doc Link 9935276 Disease Relevance 0 Pain Relevance 0.13
Furthermore, we establish a direct interaction between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sensory neurons.
alpha2 integrin Binding (interaction) of in sensory neurons
4) Confidence 0.00 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18234883 Disease Relevance 1.14 Pain Relevance 0.91

General Comments

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