INT79841

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.37
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
tube 1
monocytes 1
leucocyte 1
neutrophils 1
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 99.60 Very High Very High Very High
Inflammatory response 28 89.92 High High
aspirin 3 68.56 Quite High
Inflammation 45 65.04 Quite High
Nicotine 86 53.04 Quite High
imagery 33 50.00 Quite Low
metalloproteinase 18 50.00 Quite Low
dexamethasone 2 30.32 Quite Low
Angina 2 25.00 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 40 98.26 Very High Very High Very High
INFLAMMATION 75 89.56 High High
Cancer 82 88.24 High High
Osteoporosis 12 50.00 Quite Low
Disease 12 37.84 Quite Low
Disseminated Intravascular Coagulation 1 34.72 Quite Low
Cv General 3 Under Development 4 25.00 Low Low
Hemorrhage 2 25.00 Low Low
Myocardial Infarction 2 25.00 Low Low
Emergencies 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also binds to alphavbeta3 and leucocyte MAC-1 receptors; the biological significance of its affinity to these receptors is unclear.
MAC-1 Binding (binds) of in leucocyte
1) Confidence 0.47 Published 1999 Journal Drug Saf Section Abstract Doc Link 9935276 Disease Relevance 0 Pain Relevance 0.12
For flow cytometry analysis the cells were detached with 0.05% trypsin/EDTA and washed with PBS. 1 × 105 cells per tube were blocked for 5 minutes with human AB serum (Sigma) and stained for 15 minutes incubated in an ice bath in the dark with direct PE or FITC conjugated mouse anti-human monoclonal antibodies (Becton Dickinson) recognizing CD11b, CD34, CD38, CD44, CD45, CD73, CD90, CD117 and HLA-DR.
CD11b Binding (recognizing) of in tube
2) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
As shown in Figure 4D, a significant population of CD11b-positive cells had indeed bound injected AC133.1 (double-positive population in the left and right panel of Figure 4D).
CD11b Binding (bound) of
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.20 Pain Relevance 0
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
CD11b Binding (bind) of in monocytes associated with adhesions
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.58 Pain Relevance 0.15
Expression of CD11b (integrin ?
CD11b Binding (integrin) of
5) Confidence 0.13 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0 Pain Relevance 0.05
Specific adhesion molecules important in mediating adhesive interactions include CD62L (L-selectin) and CD11b (Mac-1) on neutrophils and monocytes, which bind to their corresponding counter-receptors to facilitate leukocyte-endothelial cell interactions [5]–[8].
CD11b Binding (bind) of in neutrophils associated with adhesions
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.58 Pain Relevance 0.15

General Comments

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