INT79862

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.67
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANPEP) cytosol (ANPEP) peptidase activity (ANPEP)
plasma membrane (ANPEP) cytoplasm (ANPEP)
Anatomy Link Frequency
eosinophils 2
glands 2
ANPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 11 98.08 Very High Very High Very High
opioid receptor 1 97.60 Very High Very High Very High
agonist 1 95.44 Very High Very High Very High
cytokine 14 91.52 High High
Neuropeptide 1 87.36 High High
dexamethasone 1 83.84 Quite High
chemokine 5 63.08 Quite High
Analgesic 1 25.00 Low Low
Antihistamine 1 16.08 Low Low
nud 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 90 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 85.40 High High
Occupational Lung Diseases 1 82.12 Quite High
Hypersensitivity 10 81.68 Quite High
Prostate Cancer 26 76.16 Quite High
Eosinophilia 27 70.24 Quite High
Vomiting 22 50.00 Quite Low
Recurrence 11 47.48 Quite Low
Disease 38 24.72 Low Low
Food Hypersensitivity 9 21.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was paralleled by a loss in cell surface expression of APN at physiological (10(-10) M) concentrations of MENK.
Negative_regulation (loss) of Gene_expression (expression) of APN associated with enkephalin
1) Confidence 0.38 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 9950265 Disease Relevance 0 Pain Relevance 0.86
In two cases, the cancer glands were positive for CD13, and a small subpopulation of CD13+ tumor cells was present in one case.
Negative_regulation (present) of Gene_expression (positive) of CD13 in glands associated with cancer
2) Confidence 0.21 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.30 Pain Relevance 0
Treatment with high dose methylprednisolone results in significant reduction in peripheral blood eosinophils and phenotypic changes characterized by decreased expression of CD11b, CD18, and CD13 which have an important role in the action of eosinophils [46].
Negative_regulation (decreased) of Gene_expression (expression) of CD13 in eosinophils
3) Confidence 0.05 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.38 Pain Relevance 0.12

General Comments

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