INT79887

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2009
Negated 7
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 12.59
Pain Relevance 14.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcc) plasma membrane (Prkcc) nucleus (Prkcc)
kinase activity (Prkcc) response to stress (Prkcc) cytoplasm (Prkcc)
Anatomy Link Frequency
neurons 3
dorsal horn 2
SNL 1
spinal cord 1
brain 1
Prkcc (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 45 100.00 Very High Very High Very High
Spinal cord 29 99.92 Very High Very High Very High
Morphine 26 99.82 Very High Very High Very High
Thermal hyperalgesia 7 99.70 Very High Very High Very High
Peripheral nerve injury 9 99.56 Very High Very High Very High
GABAergic 4 99.48 Very High Very High Very High
Neuropathic pain 23 99.40 Very High Very High Very High
imagery 6 99.40 Very High Very High Very High
Pain 35 99.04 Very High Very High Very High
Dorsal horn 6 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 19 99.96 Very High Very High Very High
Hyperalgesia 14 99.70 Very High Very High Very High
Nervous System Injury 15 99.56 Very High Very High Very High
Neuropathic Pain 30 99.40 Very High Very High Very High
Pain 31 99.04 Very High Very High Very High
Injury 25 98.92 Very High Very High Very High
Sprains And Strains 20 98.60 Very High Very High Very High
Frailty 12 98.56 Very High Very High Very High
Hypersensitivity 4 96.72 Very High Very High Very High
Contusions 6 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, there was increased expression of protein kinase C gamma (PKCgamma) in cells outside of the inner region of lamina II (IIi) in both strains after spinal contusion injury.
Gene_expression (expression) of PKCgamma in spinal associated with kinase c, injury, contusions and sprains and strains
1) Confidence 0.78 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17586495 Disease Relevance 2.20 Pain Relevance 0.63
However, the PKCgamma KO mice and the 129S6 mice (which express PKCgamma) did not show abnormal pain after SNL; neither strain showed elevated levels of spinal dynorphin.
Gene_expression (express) of PKCgamma in SNL associated with pain, dynorphin and sprains and strains
2) Confidence 0.77 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667440 Disease Relevance 1.70 Pain Relevance 1.12
Because the spinal cord distribution of interneurons that express PKCgamma is concentrated almost exclusively in the inner part of lamina II, we believe that changes in the properties of these neurons are key to the development of nerve injury-induced neuropathic pain conditions.
Gene_expression (express) of PKCgamma in nerve associated with nervous system injury, neuropathic pain and spinal cord
3) Confidence 0.72 Published 1999 Journal Reg Anesth Pain Med Section Abstract Doc Link 9952097 Disease Relevance 1.53 Pain Relevance 1.07
PKCgamma is distributed strategically in the superficial layers of the dorsal horn and, thus, may serve as an important biochemical substrate in sensory signal processing including pain.
Gene_expression (distributed) of PKCgamma in dorsal horn associated with pain and dorsal horn
4) Confidence 0.67 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278552 Disease Relevance 0.23 Pain Relevance 0.72
A significant place preference was observed following treatment with morphine in wild-type mice, whereas such an effect of morphine was not found in PKCgamma knockout mice.
Neg (not) Gene_expression (found) of PKCgamma associated with targeted disruption and morphine
5) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.10 Pain Relevance 0.98
Furthermore, we investigated the rewarding properties of morphine in mice lacking PKCgamma gene.
Neg (lacking) Gene_expression (lacking) of PKCgamma gene associated with morphine
6) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.09 Pain Relevance 0.99
In contrast, i.t. injection of PDBu failed to cause thermal hyperalgesia in mice which lacked the PKCgamma gene.
Neg (lacked) Gene_expression (lacked) of PKCgamma associated with thermal hyperalgesia
7) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18242849 Disease Relevance 0.10 Pain Relevance 0.70
In addition, all effects of PDBu were abolished in mice that lacked the PKCgamma gene.
Neg (lacked) Gene_expression (lacked) of PKCgamma
8) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18242849 Disease Relevance 0.07 Pain Relevance 0.88
The aim of the present study was to investigate whether direct activation of protein kinase C (PKC) in the spinal cord could change brain activation using a functional magnetic resonance imaging (fMRI) analysis in mice that lack the PKCgamma gene.
Neg (lack) Gene_expression (lack) of PKCgamma in brain associated with kinase c, imagery and spinal cord
9) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18242849 Disease Relevance 0.08 Pain Relevance 0.63
The multiple phenotypic deficits in PKCgamma KO mice confound the interpretation of the proposed role of PKCgamma-expressing spinal neurons in neuropathic pain states.
Gene_expression (expressing) of PKCgamma-expressing in neurons associated with neuropathic pain
10) Confidence 0.67 Published 2004 Journal Neuroscience Section Abstract Doc Link 14667440 Disease Relevance 1.43 Pain Relevance 1.04
The immunoprecipitation analysis showed that p-PKCgamma and Vps34 are present together in molecular complexes.
Gene_expression (present) of p-PKCgamma
11) Confidence 0.66 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.39
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Gene_expression (levels) of PKCgamma in spinal cord associated with spinal cord
12) Confidence 0.66 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.82
The treatment with morphine increases PKCgamma and Vps34 levels.
Gene_expression (levels) of PKCgamma associated with morphine
13) Confidence 0.66 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
Histological analyses confirmed increased sprouting of sensory fibers containing calcitonin-gene related peptide (CGRP) in the deep dorsal horn of the lumbar spinal cord and increased numbers of interneurons expressing protein kinase C gamma (PKCgamma) in WT mice 6 weeks after injury.
Gene_expression (expressing) of PKCgamma in dorsal horn associated with kinase c, injury, dorsal horn and spinal cord
14) Confidence 0.65 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19059398 Disease Relevance 1.90 Pain Relevance 0.59
These data demonstrate that L1 plays a role in maintenance of thermal hyperalgesia after SCI in mice, and implicate CGRP(+) fiber sprouting and the upregulation of PKCgamma expression as potential contributors to this response.
Gene_expression (expression) of PKCgamma associated with thermal hyperalgesia and frailty
15) Confidence 0.65 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19059398 Disease Relevance 1.47 Pain Relevance 0.46
Protein kinase C (PKC) is thought to have a role in sensitization of dorsal horn neurons in certain pain states, and a recent study has reported that mice which lack the gamma isoform (PKCgamma) show reduced neuropathic pain after peripheral nerve injury.
Neg (lack) Gene_expression (lack) of PKCgamma in neurons associated with pain, kinase c, nervous system injury, neuropathic pain, dorsal horn neuron and peripheral nerve injury
16) Confidence 0.61 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375678 Disease Relevance 0.30 Pain Relevance 0.45
Dual-immunofluorescence labelling showed that PKCgamma was not randomly distributed amongst non-GABAergic neurons, since it was present in 76% of cells with neurotensin and 45% of those with somatostatin, but only 5% of those with the mu-opioid receptor (MOR-1).
Neg (not) Gene_expression (distributed) of PKCgamma in GABAergic neurons associated with gabaergic, somatostatin and opioid receptor
17) Confidence 0.61 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375678 Disease Relevance 0.22 Pain Relevance 0.61
Cells with the neurokinin 1 receptor are found in lamina I and lamina III, and PKCgamma was present in 22% and 37% of these populations, respectively.
Gene_expression (present) of PKCgamma in lamina
18) Confidence 0.61 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375678 Disease Relevance 0.18 Pain Relevance 0.59
Although PKCgamma is present at high levels in the ventral part of lamina II we have limited information concerning the types of neuron in which it is located.
Gene_expression (present) of PKCgamma in neuron
19) Confidence 0.55 Published 1999 Journal Brain Res. Section Abstract Doc Link 10375678 Disease Relevance 0.29 Pain Relevance 0.44
There was also no overlap between the PKCgamma-expressing interneurons and the transganglionic tracer wheat germ agglutinin which, after sciatic nerve injection, labels all unmyelinated nociceptors.
Gene_expression (expressing) of PKCgamma in nociceptors associated with nociceptor, sciatic nerve and unmyelinated
20) Confidence 0.52 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18685019 Disease Relevance 0.33 Pain Relevance 0.68

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