INT79902

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 42
Disease Relevance 24.72
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (AQP1) plasma membrane (AQP1) nucleus (AQP1)
transmembrane transport (AQP1) cytoplasm (AQP1)
Anatomy Link Frequency
plasma 11
astrocytes 7
cerebral cortex 3
chondrocytes 2
glial cells 2
AQP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 28 99.68 Very High Very High Very High
Hippocampus 15 99.00 Very High Very High Very High
Peripheral nervous system 45 98.36 Very High Very High Very High
Central nervous system 63 98.20 Very High Very High Very High
Pain 22 97.76 Very High Very High Very High
Chronic pancreatitis 20 96.52 Very High Very High Very High
Spinal cord 184 96.40 Very High Very High Very High
Neurotransmitter 35 94.44 High High
potassium channel 48 93.72 High High
Inflammation 78 89.84 High High
Disease Link Frequency Relevance Heat
Disease 1208 99.46 Very High Very High Very High
Cataract 9 99.32 Very High Very High Very High
Creutzfeldt Jakob Disease 130 99.08 Very High Very High Very High
Lewy Body Disease 39 99.00 Very High Very High Very High
Brain Tumor 9 99.00 Very High Very High Very High
Gastroenteritis 14 98.78 Very High Very High Very High
Cryptosporidiosis 644 98.32 Very High Very High Very High
Pain 20 97.76 Very High Very High Very High
Pancreatitis 32 97.08 Very High Very High Very High
Alzheimer's Dementia 84 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP1 expression was significantly increased in plasma membranes of pancreatic ducts in AIP.
Gene_expression (expression) of AQP1 in plasma
1) Confidence 0.78 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.22 Pain Relevance 0.18
Upregulation of AQP1 expression seen in pancreatic ducts of patient with AIP may be caused by the reduced fluid secretion from the pancreas as compensation.
Gene_expression (expression) of AQP1 in pancreas
2) Confidence 0.78 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.22 Pain Relevance 0.18
Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.
Gene_expression (expressed) of AQP1 in plasma
3) Confidence 0.78 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.25 Pain Relevance 0.18
Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.
Gene_expression (expressed) of aquaporin 1 in plasma
4) Confidence 0.78 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.25 Pain Relevance 0.18
Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis.
Gene_expression (overexpressed) of Aquaporin 1 in plasma associated with pancreatitis
5) Confidence 0.68 Published 2009 Journal J. Med. Invest. Section Title Doc Link 20224214 Disease Relevance 0.28 Pain Relevance 0.18
Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis.
Gene_expression (overexpressed) of water channel in plasma associated with pancreatitis
6) Confidence 0.68 Published 2009 Journal J. Med. Invest. Section Title Doc Link 20224214 Disease Relevance 0.28 Pain Relevance 0.18
Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.
Gene_expression (expressed) of water channel in plasma
7) Confidence 0.68 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.25 Pain Relevance 0.17
Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.
Gene_expression (expressed) of aquaporin 1 in plasma
8) Confidence 0.68 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.25 Pain Relevance 0.18
Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.
Gene_expression (them) of AQP1 in plasma
9) Confidence 0.68 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.25 Pain Relevance 0.18
Among them aquaporin 1 (AQP1) is a predominant water channel expressed in the plasma membranes of human pancreatic ducts.
Gene_expression (them) of water channel in plasma
10) Confidence 0.59 Published 2009 Journal J. Med. Invest. Section Abstract Doc Link 20224214 Disease Relevance 0.25 Pain Relevance 0.18
A 28 kDa protein, subsequently known as CHIP28 and re-named AQP1 for Aquaporin 1, was purified from red blood cells and renal proximal tubule membranes [3, 22] and then characterized as a water channel showing that Xenopus Laevis oocytes expressing AQP1 in their plasma membrane were far more susceptible to osmotic lysis than non-expressing oocytes [77].
Gene_expression (expressing) of AQP1 in plasma
11) Confidence 0.52 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.06 Pain Relevance 0
However, treatment with hydrogen peroxide did not affect the levels of AQP1 protein expression in human astrocytes culture, suggesting that these stimuli do not directly up-regulate AQP1 expression in astrocytes.
Gene_expression (expression) of AQP1 in astrocytes
12) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.87 Pain Relevance 0
However, treatment with hydrogen peroxide did not affect the levels of AQP1 protein expression in human astrocytes culture, suggesting that these stimuli do not directly up-regulate AQP1 expression in astrocytes.
Gene_expression (expression) of AQP1 in astrocytes
13) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.75 Pain Relevance 0
Furthermore, Rodriguez and colleagues [79] analyzed AQP1 and AQP4 expression in the cerebral cortex of CJD patients compared to that in cases with AD and diffuse Lewy body disease (DLB).
Spec (analyzed) Gene_expression (expression) of AQP1 in body associated with creutzfeldt jakob disease, lewy body disease, disease and cerebral cortex
14) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.46 Pain Relevance 0.05
This study also revealed the lack of uniformity of AQP1 expression when comparing astrocytes: some astrocytes were not stained with anti-AQP1 antibodies, whereas AQP1 expression was marked in others.
Gene_expression (expression) of AQP1 in astrocytes
15) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.57 Pain Relevance 0.04
This may explain the lack of relationship between the number of astrocytes (revealed with anti-GFAP antibodies), and the expression of AQP1 in individual cases.
Gene_expression (expression) of AQP1 in astrocytes
16) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.53 Pain Relevance 0.04
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Gene_expression (expression) of AQP1 associated with creutzfeldt jakob disease, lewy body disease and disease
17) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.54 Pain Relevance 0.05
To evaluate the hypothesis described above, a recent study using combined Western blotting and immunohistochemistry in a selected number of sporadic and familial AD showed that the levels of AQP1 expression are significantly elevated in the frontal cerebral cortex of AD patients.
Gene_expression (expression) of AQP1 in cerebral cortex associated with disease and cerebral cortex
18) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.61 Pain Relevance 0.08
This study also revealed the lack of uniformity of AQP1 expression when comparing astrocytes: some astrocytes were not stained with anti-AQP1 antibodies, whereas AQP1 expression was marked in others.
Gene_expression (expression) of AQP1 in astrocytes
19) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.57 Pain Relevance 0.04
The present findings showing increased AQP1 expression in selected astrocytes may represent a link between well-known arteriolar and capillary abnormalities [23, 46] and specific responses to water transport in perivascular processes of astrocytes in AD.
Gene_expression (expression) of AQP1 in capillary associated with congenital anomalies and disease
20) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.55 Pain Relevance 0.04

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