INT79915

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1999
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 35
Disease Relevance 12.97
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) extracellular matrix organization (Agt)
Anatomy Link Frequency
plasma 2
kidney 2
liver 1
endothelium 1
central nervous system 1
Agt (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 97.88 Very High Very High Very High
Kinase C 13 97.68 Very High Very High Very High
Central nervous system 10 97.56 Very High Very High Very High
substance P 4 93.44 High High
fibrosis 159 92.88 High High
bradykinin 20 92.80 High High
Inflammation 191 92.24 High High
cytokine 22 90.80 High High
anesthesia 11 82.32 Quite High
Eae 3 81.60 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 64 100.00 Very High Very High Very High
Nociception 2 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 107 99.48 Very High Very High Very High
Chronic Renal Failure 10 99.22 Very High Very High Very High
Metastasis 80 99.16 Very High Very High Very High
Hypertension 289 98.96 Very High Very High Very High
Pressure And Volume Under Development 36 98.96 Very High Very High Very High
Colon Cancer 82 98.82 Very High Very High Very High
Cognitive Disorder 31 98.64 Very High Very High Very High
Cancer 76 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, while direct renin inhibitors will decrease levels of Ang II, most ARBs lead to increased levels of Ang II.
Positive_regulation (increased) of Ang II
1) Confidence 0.56 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.41 Pain Relevance 0.16
Presumably these increases in AngII exceed the degradative capacity of APA and hypertension results.
Positive_regulation (increases) of AngII associated with hypertension
2) Confidence 0.55 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.58 Pain Relevance 0
Since it is known that a high-salt diet increases intrarenal angiotensinogen levels in DSS rats, elevations in AngII levels would be anticipated [45].
Positive_regulation (elevations) of AngII
3) Confidence 0.55 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.51 Pain Relevance 0
The importance of AT2 receptor subtype for the nociception reducing effect of AngII is considered.
Positive_regulation (importance) of AngII associated with nociception
4) Confidence 0.50 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9972688 Disease Relevance 0.19 Pain Relevance 0.17
Since it is known that a high-salt diet increases intrarenal angiotensinogen levels in DSS rats, elevations in AngII levels would be anticipated [45].
Positive_regulation (increases) of angiotensinogen
5) Confidence 0.48 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.50 Pain Relevance 0
We made use of targeted disruption of the mouse angiotensinogen (ATN) gene to examine the functional role of the ATN in the central nervous system.
Positive_regulation (disruption) of angiotensinogen in central nervous system associated with targeted disruption and central nervous system
6) Confidence 0.45 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081975 Disease Relevance 0.33 Pain Relevance 0.19
From day 6 through day 14, the MAP had increased (P < 0.01) in AngII400, accompanied by a significant reduction in GFR to 1.05 +/- 0.04 ml. min(-1). g(-1) (P < 0.01) and elevation of renal vascular resistance (RVR) (day 6 versus day 14, 15.3 +/- 0.6 versus 19.2 +/- 1.2 mmHg. ml(-1). min(-1). g(-1); P < 0.05).
Positive_regulation (increased) of AngII400
7) Confidence 0.41 Published 2002 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 12444204 Disease Relevance 0.14 Pain Relevance 0.08
The SBP of conscious mice increased by day 3 at AngII1000 but showed a delayed rise by days 9 to 13 (slow pressor response) at the lower rates of AngII infusion.
Positive_regulation (increased) of AngII1000
8) Confidence 0.41 Published 2002 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 12444204 Disease Relevance 0.17 Pain Relevance 0.08
In addition, while direct renin inhibitors will decrease levels of Ang II, most ARBs lead to increased levels of Ang II.
Positive_regulation (lead) of Ang II
9) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.41 Pain Relevance 0.16
The lower doses of APA may be below the threshold to induce compensatory increases in circulating AngII.
Positive_regulation (increases) of AngII
10) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.05 Pain Relevance 0.04
APA activity was upregulated during AngII-induced cell proliferation; thus, it appears that increased levels of either AngII or APA result in a compensatory response, presumably representing an attempt to maintain homeostasis.
Positive_regulation (upregulated) of AngII
11) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0 Pain Relevance 0.05
Since both block AngII action via degradation and binding of AngII, respectively, the antihypertensive effect results from a loss of AngII stimulation in pregnant SHRs.
Positive_regulation (action) of AngII
12) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.15 Pain Relevance 0
AMCMs, which were serum-deprived for 1 h, and then stimulated with AngII and aldosterone (1 ?
Positive_regulation (stimulated) of AngII
13) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0 Pain Relevance 0
While they block the AT1 receptor and negative many of the ill effects of Ang II, there is a paucity of information about the long term effects of elevated Ang II levels on the AT2 receptors.
Positive_regulation (elevated) of Ang II
14) Confidence 0.37 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.39 Pain Relevance 0.13
Although increased circulating levels of AngII in APA KO mice result in hypertension, it may not stimulate the synthesis of growth factor-?
Positive_regulation (increased) of AngII associated with hypertension
15) Confidence 0.37 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.53 Pain Relevance 0
Although SHRs do not evidence elevated renin activity or increased plasma AngII concentrations relative to their normotensive counterpart Wistar-Kyoto (WKY) rats, they do possess a supersensitivity to AngII [60].
Neg (not) Positive_regulation (increased) of AngII in plasma
16) Confidence 0.37 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.18 Pain Relevance 0
Ventricular ANP and BNP mRNA expression was also significantly increased by AngII in both genotypes but did not significantly differ between genotypes (Table 1).
Positive_regulation (tly incre) of AngII
17) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.21 Pain Relevance 0.32
Increased sensitivity to AngII was only observed in first CBA/J x DBA/2 pregnancies.
Positive_regulation (Increased) of AngII
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.22 Pain Relevance 0
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Positive_regulation (increased) of angiotensin in kidney associated with renal disease
19) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.88 Pain Relevance 0.17
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Positive_regulation (activation) of angiotensin in kidney associated with renal disease
20) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.88 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox