INT79938

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 11.22
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
leucocytes 6
endothelial cells 6
monocyte 4
plasma 2
blood vessels 2
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 59 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
Central nervous system 15 98.24 Very High Very High Very High
Inflammatory response 22 95.40 Very High Very High Very High
Inflammation 171 94.08 High High
Multiple sclerosis 140 92.60 High High
qutenza 4 91.20 High High
metalloproteinase 3 88.40 High High
Nicotine 20 86.16 High High
c fibre 2 86.08 High High
Disease Link Frequency Relevance Heat
Adhesions 297 100.00 Very High Very High Very High
Nicotine Addiction 372 99.12 Very High Very High Very High
INFLAMMATION 191 98.12 Very High Very High Very High
Cancer 40 96.32 Very High Very High Very High
Necrosis 17 95.84 Very High Very High Very High
Increased Venous Pressure Under Development 90 93.80 High High
Demyelinating Disease 154 92.60 High High
Atherosclerosis 8 92.44 High High
Thrombosis 15 89.64 High High
Diabetes Mellitus 255 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of VCAM-1 on cells is regulated, at least in part, by multiple microenvironmental influences, such as changes in cytokine concentrations (19).
Regulation (regulated) of Gene_expression (expression) of VCAM-1 associated with cytokine
1) Confidence 0.61 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.07 Pain Relevance 0.09
We examined the direct effect of cutaneous neuropeptides on the expression and function of human dermal microvascular endothelial cell (HDMEC) VCAM-1.
Spec (examined) Regulation (effect) of Gene_expression (expression) of VCAM-1 in endothelial cell associated with neuropeptide
2) Confidence 0.54 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.19 Pain Relevance 0.53
Extravasation of particular subsets of leukocytes depends upon the regulated expression of cellular adhesion molecules such as VCAM-1 on microvascular endothelial cells.
Regulation (regulated) of Gene_expression (expression) of VCAM-1 in leukocytes associated with adhesions
3) Confidence 0.54 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.20 Pain Relevance 0.45
For example, VCAM-1 expression on endothelial cells is induced by interleukin-1?
Regulation (endothelial cells) of Gene_expression (expression) of VCAM-1 in endothelial cells
4) Confidence 0.45 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.90 Pain Relevance 0.09
The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.
Regulation (resulting) of Gene_expression (expression) of VCAM-1 in plasma
5) Confidence 0.38 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.31 Pain Relevance 0
Adams et al. [102] were able to show upregulation of ICAM-1 (but not VCAM-1 or E-selectin) expression on HUVECs exposed to smokers' serum, and to confirm increased monocyte-endothelium adhesion in smokers selected to exhibit no other major risk factor for vascular disease.
Regulation (upregulation) of Gene_expression (expression) of VCAM-1 in monocyte associated with nicotine addiction, increased venous pressure under development and adhesions
6) Confidence 0.36 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.85 Pain Relevance 0.18
Adams et al. [102] were able to show upregulation of ICAM-1 (but not VCAM-1 or E-selectin) expression on HUVECs exposed to smokers' serum, and to confirm increased monocyte-endothelium adhesion in smokers selected to exhibit no other major risk factor for vascular disease.
Regulation (upregulation) of Gene_expression (expression) of VCAM-1 in monocyte associated with nicotine addiction, increased venous pressure under development and adhesions
7) Confidence 0.36 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.85 Pain Relevance 0.18
No ICAM-1, VCAM-1 and L-selectin expression was found on unstimulated Schwann cells.
Regulation (found) of Gene_expression (expression) of VCAM-1 in Schwann cells
8) Confidence 0.36 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.65 Pain Relevance 0.36
Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet.
Regulation (regulation) of Gene_expression (expression) of vascular cell adhesion molecule-1 in descending aorta associated with adhesions
9) Confidence 0.20 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.42 Pain Relevance 0.12
NO inhibits rolling and adhesion of leucocytes as well as cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1) [17], probably through the inhibition of the transcription factor nuclear factor ?
Regulation (rolling) of Gene_expression (expression) of vascular cell adhesion molecule-1 in leucocytes associated with adhesions and cytokine
10) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.10 Pain Relevance 0.09
NO inhibits rolling and adhesion of leucocytes as well as cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1) [17], probably through the inhibition of the transcription factor nuclear factor ?
Regulation (rolling) of Gene_expression (expression) of VCAM-1 in leucocytes associated with adhesions and cytokine
11) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.10 Pain Relevance 0.09
Age-modified plasma proteins can bind to AGE receptors (RAGE = AGE-receptor, macrophage scavenger receptor A) on different cell types like endothelial cells, where it can adversely affect the expression of thrombomodulin, tissue factor, and VCAM-1 genes.
Regulation (affect) of Gene_expression (expression) of VCAM-1 in endothelial cells
12) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.60 Pain Relevance 0
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
Regulation (facilitated) of Gene_expression (expressed) of VCAM-1 in blood vessels associated with central nervous system and adhesions
13) Confidence 0.10 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.84 Pain Relevance 0.46

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