INT7994

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 2
Speculated 8
Reported most in Body
Documents 113
Total Number 122
Disease Relevance 69.81
Pain Relevance 19.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
synovium 9
blood 5
pore 3
epithelial cell 3
brain 2
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 53 99.84 Very High Very High Very High
aspirin 41 99.84 Very High Very High Very High
Inflammation 689 99.68 Very High Very High Very High
qutenza 10 99.64 Very High Very High Very High
dorsal root ganglion 210 99.62 Very High Very High Very High
cINOD 52 99.58 Very High Very High Very High
Inflammatory response 39 99.50 Very High Very High Very High
IPN 23 99.44 Very High Very High Very High
cytokine 179 99.16 Very High Very High Very High
Spinal cord 32 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 49 100.00 Very High Very High Very High
Cancer 2594 99.98 Very High Very High Very High
Hepatocellular Cancer 165 99.98 Very High Very High Very High
Urticaria 367 99.84 Very High Very High Very High
Rheumatoid Arthritis 174 99.84 Very High Very High Very High
Disease 246 99.80 Very High Very High Very High
Vibrio Infection 28 99.76 Very High Very High Very High
INFLAMMATION 743 99.68 Very High Very High Very High
Ganglion Cysts 263 99.62 Very High Very High Very High
Pressure And Volume Under Development 113 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of overlapping LT and nociceptive trigeminal representations in the superior colliculus seems particularly adaptive in view of the fact that rodents use their vibrissae for exploring their environment and thus put rostral body parts at risk during such behaviors.
Gene_expression (representations) of LT associated with nociception
1) Confidence 0.67 Published 1989 Journal J. Neurophysiol. Section Abstract Doc Link 2769344 Disease Relevance 0.42 Pain Relevance 0
Furthermore, LTA was detected within hepatocytes, which were mainly located around the central vein.
Gene_expression (detected) of LTA in hepatocytes
2) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.09 Pain Relevance 0.13
LTA immunoreactivities were detectable not only in the liver and gastrointestinal tract, but also in the pancreas, kidney, and spleen.
Gene_expression (detectable) of LTA in spleen
3) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.49 Pain Relevance 0.16
In our study, LTA was not detected in Kupffer cells.
Neg (not) Gene_expression (detected) of LTA in Kupffer cells
4) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.15 Pain Relevance 0.07
LTA immunoreactivity was detectable in the spleens of all TCR??
Gene_expression (detectable) of LTA in spleens
5) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.65 Pain Relevance 0.26
LTA immunoreactivity was not detectable in 3 of 3 wild-type (C57BL/6J) mice liver (Figure 1g).


Neg (not) Gene_expression (detectable) of LTA in liver
6) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.30 Pain Relevance 0.19
LTA immunoreactivity was detectable in the small intestine of all TCR??
Gene_expression (detectable) of LTA in small intestine
7) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.75 Pain Relevance 0.37
However, LTA was also detected within the cytoplasm of hepatocytes (Figure 1e,f).
Gene_expression (detected) of LTA in hepatocytes
8) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.15 Pain Relevance 0.08
Although we did not study the serum levels of LTA in these TCR??
Gene_expression (levels) of LTA
9) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.31 Pain Relevance 0.13
LTA immunoreactivity was detectable in the livers of 5 of 13 (38.4%) TCR??
Gene_expression (detectable) of LTA in livers
10) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.08 Pain Relevance 0.13
LTA was detectable in the kidneys of 5 of 13 (38.4%) TCR??
Gene_expression (detectable) of LTA
11) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.78 Pain Relevance 0.35
We also reported that LTA was detected at the portal tract in stage 1–2 PBC with chronic non-suppurative destructive cholangitis (CNSDC).
Gene_expression (detected) of LTA in stage 1 associated with cholangitis and biliary liver cirrhosis
12) Confidence 0.50 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.66 Pain Relevance 0.07
Thus it is likely that nNOS protection against LT is actually mediated through local, transient and rapid NO gradients that cannot be compensated through nitrite therapy.
Gene_expression (protection) of LT
13) Confidence 0.48 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.15 Pain Relevance 0.04
Treatment with rhEpo had no significant influence on levels of LT expression (P = 0.08), but the power of the test was too low to reject the possibility completely.
Gene_expression (expression) of LT
14) Confidence 0.44 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.32 Pain Relevance 0.08
Although, birds lack capsaicin-sensitivity they express LT noxious heat-sensitivity.
Gene_expression (express) of LT associated with qutenza
15) Confidence 0.43 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11102645 Disease Relevance 0.09 Pain Relevance 0.24
In the present study we measured levels of urinary leukotriene (LT) E(4) as an index of LT production during the menstrual cycle in adolescents.
Gene_expression (production) of LT
16) Confidence 0.43 Published 2000 Journal J Adolesc Health Section Abstract Doc Link 10960212 Disease Relevance 0.24 Pain Relevance 0.24
Nevertheless, LT alone produces the pleural edema that is a classic manifestation of anthrax.
Gene_expression (produces) of LT associated with pressure and volume under development and bacillus anthracis infection
17) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2680977 Disease Relevance 0.94 Pain Relevance 0.05
Parents expressed concern about potential LT impacts on their child's development and school achievement.
Gene_expression (expressed) of LT
18) Confidence 0.42 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC3024277 Disease Relevance 0.07 Pain Relevance 0
While recognizing substantial benefits, LT was described to also introduce challenges in daily life, with key areas of concern noted in adherence and self management of care, physical activity restriction, impact on activities of daily living, and difficult medical procedures (Table 2).
Gene_expression (introduce) of LT
19) Confidence 0.42 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC3024277 Disease Relevance 0 Pain Relevance 0
Recently our lab has shown that LT targets tumor angiogenesis [47], further supporting direct LT-mediated effects on vasculature.
Gene_expression (targets) of LT in vasculature associated with cancer
20) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.83 Pain Relevance 0.04

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