INT79941

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.97
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
plasma 1
macrophages 1
fibroblasts 1
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 97.56 Very High Very High Very High
Cannabinoid receptor 14 97.16 Very High Very High Very High
cytokine 1 94.28 High High
Inflammation 4 93.52 High High
agonist 4 87.36 High High
Cannabinoid 4 87.28 High High
tolerance 2 79.92 Quite High
addiction 2 78.80 Quite High
Bile 2 58.72 Quite High
fibrosis 1 44.16 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 54 100.00 Very High Very High Very High
Disease 131 98.80 Very High Very High Very High
Disorder Of Lipid Metabolism 40 98.40 Very High Very High Very High
Lipidosis 7 96.80 Very High Very High Very High
INFLAMMATION 6 93.52 High High
Coronary Artery Disease 130 91.48 High High
Stress 7 87.92 High High
Cytomegalovirus Infection 4 83.52 Quite High
Hyperlipidemia 25 80.72 Quite High
Diabetes Mellitus 38 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].
Negative_regulation (Loss) of NPC1 in macrophages
1) Confidence 0.59 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.66 Pain Relevance 0
A connection between the NPC1 and atherosclerosis has been established in several studies.
Negative_regulation (established) of NPC1 associated with atherosclerosis
2) Confidence 0.43 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.59 Pain Relevance 0
Homozygous mutations in the sterol-sensing domain were found to be very deleterious, corresponding to a lack of mature NPC1 protein and to a very severe disease phenotype, biochemically and clinically [47].
Negative_regulation (lack) of NPC1 associated with disease
3) Confidence 0.43 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.17 Pain Relevance 0
Ezetimibe, the first specific inhibitor of the intestinal cholesterol uptake transporter Niemann–Pick C1 Like 1 (NPC1 L1) protein, was developed as an agent to lower plasma levels of low-density lipoprotein cholesterol (LDL-C).1
Negative_regulation (inhibitor) of Niemann-Pick C1 in plasma
4) Confidence 0.42 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0 Pain Relevance 0.03
Most human cases are caused by defects in NPC1, as are the spontaneously occurring NPC diseases in mice and cats.
Negative_regulation (defects) of NPC1 associated with disease
5) Confidence 0.41 Published 2001 Journal Curr. Biol. Section Abstract Doc Link 11525744 Disease Relevance 0.56 Pain Relevance 0
The pharmacological specificity of CP55,940 stimulated [35S]GTP gamma S binding in SPM was examined with CB1 receptor antagonist, SR141716A and these studies indicated that CP55,940 stimulated [35S]GTP gamma S binding was blocked by SR141716A with a decrease (P < 0.05) in the IC50 values in the SPM from chronic EtOH group.
Negative_regulation (decrease) of SPM associated with cannabinoid receptor and antagonist
6) Confidence 0.36 Published 1999 Journal Brain Res. Section Abstract Doc Link 9974126 Disease Relevance 0 Pain Relevance 0.42
This net CP55,940 (1.5 microM) stimulated [35S]GTP gamma S binding was reduced significantly (-25%) in SPM from chronic EtOH group (175 +/- 5.25%, control; 150 +/- 8.14%, EtOH; P < 0.05).
Negative_regulation (reduced) of SPM
7) Confidence 0.36 Published 1999 Journal Brain Res. Section Abstract Doc Link 9974126 Disease Relevance 0 Pain Relevance 0.28
Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].
Negative_regulation (Loss) of NPC1 in fibroblasts
8) Confidence 0.20 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.66 Pain Relevance 0
Since the highest reporter gene expression level was detected at day 1 postadministration, the following experiments were performed using D-SPM/pDNA at w/w ratio 16, with 13.5??
Negative_regulation (using) of D-SPM/pDNA
9) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.34 Pain Relevance 0.09

General Comments

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