INT7995

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 28
Total Number 33
Disease Relevance 14.98
Pain Relevance 9.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lta) extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
mononuclear cells 2
macrophages 1
molecular layer 1
spinal cord 1
spike 1
Lta (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 18 100.00 Very High Very High Very High
Inflammation 109 99.96 Very High Very High Very High
Paracetamol 16 99.90 Very High Very High Very High
antagonist 60 99.74 Very High Very High Very High
Multiple sclerosis 22 99.72 Very High Very High Very High
Dorsal horn 15 99.66 Very High Very High Very High
long-term potentiation 214 99.60 Very High Very High Very High
Anterior cingulate cortex 6 99.16 Very High Very High Very High
COX-2 inhibitor 1 99.10 Very High Very High Very High
Neurotransmitter 13 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 2 99.98 Very High Very High Very High
INFLAMMATION 170 99.96 Very High Very High Very High
Disease 70 99.82 Very High Very High Very High
Demyelinating Disease 22 99.72 Very High Very High Very High
Body Weight 1 99.12 Very High Very High Very High
Cerebral Malaria 60 98.96 Very High Very High Very High
Death 36 98.92 Very High Very High Very High
Neurological Disease 3 98.82 Very High Very High Very High
Biliary Liver Cirrhosis 22 98.52 Very High Very High Very High
Infection 11 98.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In C57BL/6 mice exposed to APAP, no increases in hepatic transcripts of TNF or LT-alpha were found by reverse transcription-polymerase chain reaction, nor was immunoreactive serum TNF detected by enzyme-linked immunosorbent assay over 8 hours posttreatment.
Neg (no) Positive_regulation (increases) of LT-alpha associated with paracetamol
1) Confidence 0.66 Published 1998 Journal Hepatology Section Abstract Doc Link 9537442 Disease Relevance 0.94 Pain Relevance 0.68
There has been considerable evolution in the pre-, peri- and postoperative management of patients with severe lung disease undergoing LTx.
Positive_regulation (undergoing) of LTx in lung associated with pulmonary disease
2) Confidence 0.40 Published 2007 Journal Clin Transpl Section Abstract Doc Link 18637465 Disease Relevance 0.24 Pain Relevance 0
Highly selected patients may be able to undergo living-donor LTx, preserving the donor pool.
Positive_regulation (undergo) of LTx
3) Confidence 0.40 Published 2006 Journal Cancer Section Abstract Doc Link 17019735 Disease Relevance 0.73 Pain Relevance 0.06
Interestingly, at the sites of inflammation, LTA was accumulated mainly around the epithelium (Figures 2 and 3).
Positive_regulation (accumulated) of LTA in epithelium associated with inflammation
4) Confidence 0.39 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.97 Pain Relevance 0.22
It is not certain whether the accumulation of LTA causes the inflammation around bile ducts, or because of the inflammation, permeability of bile ducts are up-regulated allowing leakage of LTA to occur in these TCR??
Spec (whether) Positive_regulation (accumulation) of LTA in bile ducts associated with bile and inflammation
5) Confidence 0.39 Published 2007 Journal Autoimmunity Section Body Doc Link PMC2409170 Disease Relevance 0.66 Pain Relevance 0.66
Our laboratory and others have been unable to induce LT-mediated endothelial cell death in vitro (data not shown and [50]) but endothelial barrier dysfunction is induced by the toxin in a manner independent of cell death [50].
Positive_regulation (induce) of LT in endothelial cell associated with death
6) Confidence 0.36 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.93 Pain Relevance 0.04
LTA induced up to a nine-fold increase in VEGF protein expression in macrophages, a 2.4-fold increase in MDPC-23, and a 1.6-fold increase in OD-21 as compared with controls.
Positive_regulation (induced) of LTA in macrophages
7) Confidence 0.35 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12766200 Disease Relevance 0.25 Pain Relevance 0.17
After induction of anesthesia for LT, a pulmonary flotation catheterization showed severe PH (>40 mm Hg).
Positive_regulation (induction) of LT associated with anesthesia and hypertension
8) Confidence 0.33 Published 2004 Journal Transplant. Proc. Section Abstract Doc Link 15561204 Disease Relevance 1.63 Pain Relevance 0.10
Furthermore, the LT effects reported here are in the context of a bolus toxin injection model, and it is more than likely that B. anthracis infections would target numerous organs earlier during the course of disease, before LT levels affecting the heart or endothelium are reached.
Positive_regulation (reached) of LT in heart associated with disease and infection
9) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.31 Pain Relevance 0.06
However, the results for LT are surprising: Engwerda et al had pointed at the importance of LT, as C57BL/6 mice deficient for LT-?
Positive_regulation (importance) of LT
10) Confidence 0.28 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.53 Pain Relevance 0.05
Stimulation of the LT evoked DRPs bilaterally.
Positive_regulation (Stimulation) of LT
11) Confidence 0.27 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307119 Disease Relevance 0.08 Pain Relevance 0.16
Nevertheless, here LT mRNA levels were not increased in ECM compared to uninfected controls.
Neg (not) Positive_regulation (increased) of LT mRNA
12) Confidence 0.26 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.46 Pain Relevance 0.07
1; P < 0.05, n= 4). sAPs were also increased in frequency following superfusion of LTX and atropine (1 ?
Positive_regulation (superfusion) of LTX
13) Confidence 0.24 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.06
Superfusion of LTX (1 nm) for 10 min produced a 438 ± 95% increase in sDep frequency (to 35.3 ± 8.3 min?
Positive_regulation (Superfusion) of LTX
14) Confidence 0.24 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.13
MATERIAL AND METHODS: A retrospective study of the journals of 440 patients, who underwent 506 LTXs between 1992 and 2005, showed that 14 patients underwent LTX for PLD.
Positive_regulation (underwent) of LTX
15) Confidence 0.24 Published 2008 Journal Scand. J. Gastroenterol. Section Body Doc Link 18938751 Disease Relevance 0 Pain Relevance 0
RESULTS: Thirty-one patients (43%) recovered with medical therapy, 29 (40%) patients died, and 12 (17%) underwent LT.
Positive_regulation (underwent) of LT
16) Confidence 0.17 Published 2006 Journal Transplant. Proc. Section Body Doc Link 16980011 Disease Relevance 0.08 Pain Relevance 0
The Na+ channel blocker tetrodotoxin (1 microM) eliminated the evoked CA1 population spike but not the LT increase, indicating that the domoate signal is not associated with action potential discharge pre- or post-synaptically.
Neg (not) Positive_regulation (increase) of LT in spike associated with action potential and tetrodotoxin
17) Confidence 0.13 Published 1996 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8909784 Disease Relevance 0.05 Pain Relevance 0.40
Moreover repeated stimulation of LT produced LTP of LT- but not DR-evoked potentials.
Positive_regulation (stimulation) of LT associated with long-term potentiation
18) Confidence 0.13 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11160487 Disease Relevance 0.08 Pain Relevance 0.99
A brief 1-min exposure to 10 microM domoate at 22 degrees C elevated LT by 58% in the apical dendritic region of CA1 and to a lesser extent in the molecular layer of the upper dentate gyrus.
Positive_regulation (elevated) of LT in molecular layer
19) Confidence 0.12 Published 1996 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8909784 Disease Relevance 0.16 Pain Relevance 0.18
Compared with patients with aseptic meningo-encephalitis, non-inflammatory neurological diseases and healthy controls, the multiple sclerosis patients had elevated numbers of TNF-alpha and LT mRNA expressing mononuclear cells in blood when enumerated without previous culture, and also after culture with MBP.
Positive_regulation (elevated) of LT in mononuclear cells associated with multiple sclerosis, neurological disease, inflammation and viral meningitis
20) Confidence 0.11 Published 1996 Journal Brain Section Abstract Doc Link 8624683 Disease Relevance 1.30 Pain Relevance 0.44

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