INT79955

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Context Info
Confidence 0.81
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 26
Total Number 31
Disease Relevance 8.44
Pain Relevance 19.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
dorsal horn 5
brain 4
nucleus accumbens 2
spinal 2
paw 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 127 100.00 Very High Very High Very High
Cannabinoid receptor 94 100.00 Very High Very High Very High
Pain 70 100.00 Very High Very High Very High
Opioid 23 100.00 Very High Very High Very High
mu opioid receptor 20 100.00 Very High Very High Very High
nociceptor 19 100.00 Very High Very High Very High
Glutamate 18 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
nMDA receptor 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 49 99.40 Very High Very High Very High
Pain 116 99.34 Very High Very High Very High
Ganglion Cysts 17 99.20 Very High Very High Very High
Spasticity 2 99.16 Very High Very High Very High
INFLAMMATION 73 98.76 Very High Very High Very High
Dyskinesias 2 98.08 Very High Very High Very High
Convulsion 2 97.16 Very High Very High Very High
Post Operative Pain 110 96.68 Very High Very High Very High
Amnesia 2 96.60 Very High Very High Very High
Obesity 76 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord.
Localization (localization) of cannabinoid receptor-1 in dorsal horn associated with cannabinoid receptor, nociceptor, dorsal horn and spinal cord
1) Confidence 0.81 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12161251 Disease Relevance 0.10 Pain Relevance 0.83
Compartment-specific localization of cannabinoid 1 (CB1) and mu-opioid receptors in rat nucleus accumbens.
Localization (localization) of cannabinoid 1 in nucleus accumbens associated with nucleus accumbens, cannabinoid and mu opioid receptor
2) Confidence 0.80 Published 2004 Journal Neuroscience Section Title Doc Link 15219673 Disease Relevance 0 Pain Relevance 0.77
Compartment-specific localization of cannabinoid 1 (CB1) and mu-opioid receptors in rat nucleus accumbens.
Localization (localization) of CB1 in nucleus accumbens associated with nucleus accumbens, cannabinoid and mu opioid receptor
3) Confidence 0.80 Published 2004 Journal Neuroscience Section Title Doc Link 15219673 Disease Relevance 0 Pain Relevance 0.77
A strong co-localization of CB1 and mu-opioid receptors was observed in lamina II interneurons at the ultrastructural level.
Localization (co-localization) of CB1 in interneurons associated with mu opioid receptor
4) Confidence 0.80 Published 2001 Journal Neuroreport Section Abstract Doc Link 11726775 Disease Relevance 0.09 Pain Relevance 0.58
Pre- and postsynaptic localizations of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cord.
Localization (localizations) of CB1 in dorsal horn associated with cannabinoid receptor, cannabinoid, dorsal horn and spinal cord
5) Confidence 0.78 Published 2002 Journal Neuroscience Section Title Doc Link 11934482 Disease Relevance 0.17 Pain Relevance 0.86
Results show a dual pre- and postsynaptic localization of CB1 receptors.
Localization (localization) of CB1
6) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934482 Disease Relevance 0.18 Pain Relevance 0.37
Since anatomical data concerning spinal CB1 receptors are rather contradictory, we studied the cellular and subcellular localizations of the CB1 receptors by immunocytochemistry.
Localization (localizations) of CB1 in spinal
7) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934482 Disease Relevance 0.18 Pain Relevance 0.37
CB1 receptors have been localized to primary afferent neurons, but little is known about the direct effect of cannabinoids on these neurons.
Localization (localized) of CB1 in neurons associated with cannabinoid
8) Confidence 0.75 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421626 Disease Relevance 0 Pain Relevance 0.19
CB1 receptors inhibit synaptic release of glutamate in rat dorsolateral striatum, a similar mechanism of action may underlie the effects of ACEA on noxious evoked responses of spinal neurons reported here.
Localization (release) of CB1 in neurons associated with glutamate
9) Confidence 0.74 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11731561 Disease Relevance 0.17 Pain Relevance 0.60
Colocalization of CGRP with delta-opioid but not mu-opioid or CB1 receptor immunoreactivity in superficial laminae of the dorsal horn of the spinal cord was consistent with the data for agonist inhibition of peptide release.
Localization (Colocalization) of CB1 receptor in spinal cord associated with agonist, dorsal horn, opioid, spinal cord and calcitonin gene-related peptide
10) Confidence 0.74 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973253 Disease Relevance 0.07 Pain Relevance 1.52
The data suggest that CB1 receptors are co-localized with D1 or D2 receptors on the same population of striatal membranes and can interact at the level of G-protein/adenylyl cyclase signal transduction.
Localization (co-localized) of CB1
11) Confidence 0.73 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11378162 Disease Relevance 0 Pain Relevance 0.38
Endocannabinoids are key modulators of feeding behavior through the activation of the CB1 receptor (1,2), which is localized in the periphery as well as in many brain areas involved in the regulation of energy homeostasis and reward processes (3,4).
Localization (localized) of CB1 in brain associated with endocannabinoid
12) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2570394 Disease Relevance 0.52 Pain Relevance 0.13
Furthermore, CB1 and TRPV1 (transient potential receptor vanilloid subtype-1) co-localization was increased from 41% before inflammation to 67% two days after inflammation.
Localization (co-localization) of CB1 associated with inflammation
13) Confidence 0.72 Published 2006 Journal Pain Section Abstract Doc Link 16709443 Disease Relevance 1.25 Pain Relevance 1.09
Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively.
Localization (localized) of cannabinoid receptor-1 in dorsal horn associated with pain, cannabinoid receptor, primary afferent fibers, cannabinoid and dorsal horn
14) Confidence 0.71 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12161251 Disease Relevance 0.10 Pain Relevance 0.59
Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively.
Localization (localized) of CB1 in dorsal horn associated with pain, cannabinoid receptor, primary afferent fibers, cannabinoid and dorsal horn
15) Confidence 0.71 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12161251 Disease Relevance 0.10 Pain Relevance 0.59
Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry.
Localization (Localisation) of cannabinoid receptor 1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, cannabinoid receptor and nociceptor
16) Confidence 0.70 Published 2003 Journal Neuroscience Section Title Doc Link 12809701 Disease Relevance 0.57 Pain Relevance 0.93
In double labeling studies, CB1 receptor-immunoreactivity co-localized with labeling for calcitonin gene-related peptide and RT97, a marker for myelination, in some primary afferent neurons.
Localization (localized) of CB1 in afferent neurons associated with calcitonin gene-related peptide
17) Confidence 0.70 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421626 Disease Relevance 0 Pain Relevance 0.63
To determine the relevant sites, we examined the electron microscopic localization of cannabinoid type-1 (CB1) receptors and mu-opioid receptors in each Acb compartment in rat brain.
Spec (examined) Localization (localization) of CB1 in brain associated with nucleus accumbens, cannabinoid and mu opioid receptor
18) Confidence 0.70 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219673 Disease Relevance 0 Pain Relevance 0.59
On occasion CB1 receptor staining also appeared to co-localize with GFAP, an astrocyte marker (Figure 3).
Localization (localize) of CB1 receptor in astrocyte
19) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.19 Pain Relevance 0.18
Microglia (Iba-1 positive cells) and perivascular microglial cells (ED2/CD163 positive cells) did not co-localize with CB1 receptor staining in naïve animals or at any observed time following paw incision (Figure 3).
Localization (localize) of CB1 receptor in Microglia
20) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.06 Pain Relevance 0.13

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