INT79956

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 4.17
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 100.00 Very High Very High Very High
Morphine 5 91.40 High High
Inflammation 3 89.28 High High
cytokine 5 78.24 Quite High
opiate 1 76.24 Quite High
Inflammatory response 3 67.04 Quite High
Pain 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Flavivirus Infection 240 99.40 Very High Very High Very High
Dengue 312 98.04 Very High Very High Very High
Adhesions 6 96.36 Very High Very High Very High
Infection 114 94.36 High High
Apoptosis 9 91.52 High High
Convalescence 12 90.40 High High
INFLAMMATION 6 89.28 High High
Neurodegenerative Disease 1 82.16 Quite High
Disease 51 75.96 Quite High
Syndrome 3 16.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of the CP or the LP leads to activation of the (C4b2b) C3 convertase.
Positive_regulation (leads) of Positive_regulation (activation) of C3
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.50 Pain Relevance 0.03
This result suggests that the activation of the (C4b2b) C3 convertase was not mediated by differences on the levels of immune complexes in DF and DHF patients.
Neg (not) Positive_regulation (mediated) of Positive_regulation (activation) of C3 associated with flavivirus infection and dengue
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.46 Pain Relevance 0
These observations suggest that it is possible that MBL can be contributing to the increased activation of (C4b2b) C3 convertase in DHF through mechanisms that do not involve immune complexes.


Positive_regulation (increased) of Positive_regulation (activation) of C3 associated with flavivirus infection
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.69 Pain Relevance 0
Inhibition of IL-1beta mediated C3 promoter activation by the dominant negative mutant of p38-alpha mitogen-activated protein kinase suggests that IL-1beta induces C3 expression through the activation of C/EBP.
Positive_regulation (mediated) of Positive_regulation (activation) of C3
4) Confidence 0.18 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247123 Disease Relevance 0.17 Pain Relevance 0.55
In both groups of patients the serum concentrations of C3, C4, C5, and C1 inhibitor were significantly affected by the treatments (p < 0.001), decreased immediately after onset of anesthesia, were minimal during surgery, and increased thereafter.
Positive_regulation (minimal) of Positive_regulation (concentrations) of C3 associated with anesthesia
5) Confidence 0.07 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.14
In both groups of patients the serum concentrations of C3, C4, C5, and C1 inhibitor were significantly affected by the treatments (p < 0.001), decreased immediately after onset of anesthesia, were minimal during surgery, and increased thereafter.
Positive_regulation (increased) of Positive_regulation (concentrations) of C3 associated with anesthesia
6) Confidence 0.07 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.14

General Comments

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