INT79979

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 6
Speculated 6
Reported most in Body
Documents 94
Total Number 101
Disease Relevance 19.21
Pain Relevance 25.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
neurons 30
nociceptors 11
sympathetic 8
IB4 3
ganglia 3
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 1875 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1365 100.00 Very High Very High Very High
Nerve growth factor 1774 99.84 Very High Very High Very High
Spinal cord 324 99.64 Very High Very High Very High
unmyelinated 230 99.56 Very High Very High Very High
trigeminal ganglion 715 99.32 Very High Very High Very High
Pain 147 98.48 Very High Very High Very High
substance P 492 98.24 Very High Very High Very High
Peripheral nervous system 63 97.94 Very High Very High Very High
dorsal root ganglion 159 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 257 100.00 Very High Very High Very High
Ganglion Cysts 4574 99.96 Very High Very High Very High
Neurodegenerative Disease 38 98.72 Very High Very High Very High
Pain 221 98.48 Very High Very High Very High
Apoptosis 448 97.80 Very High Very High Very High
Targeted Disruption 1240 97.52 Very High Very High Very High
Death 413 91.36 High High
Neuroblastoma 9 90.24 High High
Syndrome 9 89.64 High High
Neuropathic Pain 214 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GDNF-overexpresser mice had increased numbers of small unmyelinated sensory neurons that express the tyrosine kinase receptor Ret and bind the plant isolectin B4 (IB4).
Gene_expression (express) of Ret in IB4 associated with unmyelinated
1) Confidence 0.75 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019325 Disease Relevance 0.19 Pain Relevance 0.25
ret expression in mouse DRG is detectable as early as E11 in a small number of neurons.
Gene_expression (expression) of ret in neurons
2) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.44
About 30% of ret-immunoreactive cells are calcitonin gene-related peptide (CGRP)-positive (Bennett et al. 1998).Massive overlap is found between ret expression and binding of the lectin Griffonia simplicifolia isolectin B4 (IB4).
Gene_expression (expression) of ret in IB4 associated with calcitonin gene-related peptide
3) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.37
ret and GFRalpha expression patterns in sympathetic ganglia
Gene_expression (expression) of ret in ganglia
4) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.44 Pain Relevance 0.04
In sympathetic neurons, ret expression is detected before trkA expression and appears correlated with trkC expression instead.
Gene_expression (expression) of ret in sympathetic
5) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.32
In the trigeminal ganglion of mouse embryos, GFRalpha1 and GFRalpha2 mRNAs can be detected by ISH preceding ret expression (Luukko et al. 1997).
Gene_expression (expression) of ret in embryos associated with ganglion cysts and trigeminal ganglion
6) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.43
ret-positive cells develop largely but not exclusively from trkA-positive cells In adult rats, 59%–64% of lumbar DRG neurons express ret mRNA as detected by ISH (Bennett et al. 1998, 2000; Kashiba et al. 1998, 2003) and 72% are found positive for ret protein by IHC (Bennett et al. 1998).
Gene_expression (express) of ret mRNA in neurons
7) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.31 Pain Relevance 0
In mice, percentages of cells expressing ret mRNA as determined by ISH range from 40% (Zwick et al. 2002) to 60%, corresponding to 62% immunopositive cells (Molliver et al. 1997).During mouse development, a small subpopulation of ret-positive cells is detectable at E11.5.
Gene_expression (expressing) of ret mRNA
8) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.28 Pain Relevance 0
ret expression is regulated differently during the development of mouse sympathetic and sensory ganglia.
Gene_expression (expression) of ret in ganglia
9) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.42
Expression of ret and GFRalpha receptor subunits
Gene_expression (Expression) of ret
10) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.44
Because of the limited colocalization of IB4 binding and CGRP expression (Silverman and Kruger 1990), peptidergic and non-peptidergic nociceptors have been distinguished and are correlated with trkA and ret expression, respectively.
Gene_expression (expression) of ret in nociceptors associated with nociceptor and calcitonin gene-related peptide
11) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.73
The acquisition of ret expression in trkA-positive neurons during late embryogenesis requires NGF, apart from its survival action, as shown in NGF/Bax double-mutant mice.
Gene_expression (expression) of ret in neurons associated with nerve growth factor
12) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.32
In prehatching chick embryos, ret mRNA expression in paravertebral sympathetic ganglia is highly colocalized with the cholinergic marker peptide VIP (Ernsberger et al. 1997).
Gene_expression (expression) of ret mRNA in sympathetic
13) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.17 Pain Relevance 0.04
The expression of mRNAs for GFRalpha1, GFRalpha2, GFRalpha3 and ret is dynamically regulated in mouse sympathetic ganglia during embryogenesis (Nishino et al. 1999; Enomoto et al. 2001).
Gene_expression (expression) of ret in sympathetic
14) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.46 Pain Relevance 0.04
Since ret-expressing cells are not preferentially lost in ret mutant mice (Enomoto et al. 2001) and ret is expressed in cholinergic cells in chick sympathetic ganglia (Ernsberger et al. 1997), the loss of ChAT- and VAChT-positive sympathetic cells in ret mutants may be attributable to an altered regulation of cholinergic gene expression rather than the loss of cells by cell death.
Gene_expression (expressed) of ret in ganglia associated with death
15) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.30 Pain Relevance 0
The importance of trkC signalling for ret expression in vivo remains to be determined.
Gene_expression (expression) of ret
16) Confidence 0.62 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.29
In adult DRGs, TrkC and Ret were expressed in 68% and 25% of TRPV2-positive neurons, respectively.
Gene_expression (expressed) of Ret in neurons
17) Confidence 0.56 Published 2005 Journal Neuroscience Section Abstract Doc Link 15561438 Disease Relevance 0.42 Pain Relevance 0.44
Expression of the GFRalpha3 receptor is primarily restricted to the peripheral nervous system and is found in a subpopulation of nociceptive sensory neurons of the dorsal root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1.
Gene_expression (coexpress) of Ret in dorsal root ganglia associated with nociception and peripheral nervous system
18) Confidence 0.56 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16914684 Disease Relevance 0.19 Pain Relevance 0.08
Most cells lose ret expression by E15.5 and only a subpopulation of sympathetic cells expresses ret at postnatal day 0 (P0).
Gene_expression (expresses) of ret in sympathetic
19) Confidence 0.54 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.50 Pain Relevance 0.03
During rat postnatal development, the proportion of TRPV1-immunoreactive cells coexpressing ret increases from 30% at P2 to ~50% at P10 and ~60% at P40 (Guo et al. 2001).
Gene_expression (coexpressing) of ret
20) Confidence 0.54 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.28

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