INT79981

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 12.49
Pain Relevance 10.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 8
sensory neurons 6
neuronal 6
astrocytes 4
spinal cord 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 142 100.00 Very High Very High Very High
Dorsal horn 15 100.00 Very High Very High Very High
intrathecal 3 99.98 Very High Very High Very High
Calcitonin gene-related peptide 109 99.90 Very High Very High Very High
Inflammation 73 99.84 Very High Very High Very High
Sciatic nerve 23 99.84 Very High Very High Very High
cva 4 99.84 Very High Very High Very High
Endep 21 99.68 Very High Very High Very High
antidepressant 24 99.66 Very High Very High Very High
long-term potentiation 12 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 229 100.00 Very High Very High Very High
INFLAMMATION 69 99.84 Very High Very High Very High
Cv General 3 Under Development 4 99.84 Very High Very High Very High
Nervous System Injury 46 99.72 Very High Very High Very High
Brain Ischemia 16 99.12 Very High Very High Very High
Glioblastoma 6 99.08 Very High Very High Very High
Stroke 36 99.04 Very High Very High Very High
Nociception 69 98.88 Very High Very High Very High
Ganglion Cysts 136 97.90 Very High Very High Very High
Hyperalgesia 46 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have shown that application of 1, 25 dihydroxyvitamin D(3) (D3) enhances GDNF mRNA expression in vitro.
Positive_regulation (enhances) of Gene_expression (expression) of GDNF mRNA
1) Confidence 0.70 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10699453 Disease Relevance 0.26 Pain Relevance 0.07
Furthermore, they show a difference between the regenerative responses of motor and sensory neurons to locally increased levels of NGF and GDNF.
Positive_regulation (increased) of Gene_expression (levels) of GDNF in sensory neurons associated with nerve growth factor
2) Confidence 0.60 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.16 Pain Relevance 0.25
For motoneurons, overexpression of GDNF causes trapping of regenerating axons, impairing both long-distance axonal outgrowth and reinnervation of target muscles, whereas NGF has no effect on these parameters.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GDNF in motoneurons associated with nerve growth factor
3) Confidence 0.60 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.25 Pain Relevance 0.27
For the first time we show that spinal cord LTP is associated with an increased dorsal horn expression of the genes for IL-1beta, GDNF and iNOS.
Positive_regulation (increased) of Gene_expression (expression) of GDNF in spinal cord associated with dorsal horn, long-term potentiation and spinal cord
4) Confidence 0.59 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.22 Pain Relevance 0.78
Spinal cord long-term potentiation (LTP) is associated with increased dorsal horn gene expression of IL-1beta, GDNF and iNOS.
Positive_regulation (increased) of Gene_expression (expression) of GDNF in dorsal horn associated with dorsal horn, long-term potentiation and spinal cord
5) Confidence 0.59 Published 2010 Journal Eur J Pain Section Title Doc Link 19596210 Disease Relevance 0.22 Pain Relevance 0.79
Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells.
Positive_regulation (induce) of Gene_expression (synthesis) of GDNF in glial cell associated with antidepressant and glioblastoma
6) Confidence 0.59 Published 2001 Journal J. Neurochem. Section Title Doc Link 11595754 Disease Relevance 0.18 Pain Relevance 0.59
A fibroblast cell line, engineered to overexpress GDNF, was grafted in adult rats striatum 24 h before quinolinic acid (QUIN) injection.
Positive_regulation (overexpress) of Gene_expression (overexpress) of GDNF in striatum
7) Confidence 0.58 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 9987028 Disease Relevance 0.36 Pain Relevance 0.05
Amitriptyline treatment also increased GDNF mRNA expression in rat astrocytes.
Positive_regulation (increased) of Gene_expression (expression) of GDNF in astrocytes associated with endep
8) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.55
Here, we demonstrated that long-term use of antidepressant treatment significantly increased GDNF mRNA expression and GDNF release in time- and concentration-dependent manners in rat C6 glioblastoma cells.
Positive_regulation (increased) of Gene_expression (expression) of GDNF associated with antidepressant and glioblastoma
9) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.51
Subsequently, GDNF protein levels gradually started to recover and surpassed the control level in the rostral stumps at 21 dpo, which may be explained by (1) GDNF transport within axons was strengthened, (2) inflammation leads to the increase of GDNF synthesis [36], and (3) induction of de novo synthesis of GDNF by neurons and/or non-neuronal cells.
Positive_regulation (induction) of Gene_expression (synthesis) of GDNF in neuronal associated with inflammation
10) Confidence 0.47 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.74 Pain Relevance 0.23
This potentiation of small-diameter TRG neuronal excitability is mediated by inhibition of Kv channels, and transection of sciatic nerve in rat upregulated the expression of GDNF and GFR?
Positive_regulation (upregulated) of Gene_expression (expression) of GDNF in neuronal associated with neuronal excitability, trigeminal ganglion and sciatic nerve
11) Confidence 0.46 Published 2011 Journal Mol Pain Section Body Doc Link PMC3024960 Disease Relevance 1.41 Pain Relevance 0.98
Our results also supported the mRNA expression for GDNF in neurons of the ventral horn, as well as astrocytes in white matter using in situ hybridization.
Positive_regulation (supported) of Gene_expression (expression) of GDNF in neurons
12) Confidence 0.44 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.43 Pain Relevance 0.04
For sensory neurons, increased levels of NGF and GDNF do not affect the number of regenerated neurons 1 cm distal to a lesion at 4 weeks post-lesion but do cause changes in the expression of markers for different populations of nociceptive neurons.
Positive_regulation (increased) of Gene_expression (levels) of GDNF in sensory neurons associated with nociception and nerve growth factor
13) Confidence 0.44 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.24 Pain Relevance 0.25
Intrathecal injection of GDNF and BDNF induces immediate early gene expression in rat spinal dorsal horn.
Positive_regulation (injection) of Gene_expression (injection) of GDNF in spinal associated with spinal dorsal horn and intrathecal
14) Confidence 0.43 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15899262 Disease Relevance 0.26 Pain Relevance 0.41
At 1 week after injury, the latency was almost restored to the pre-injury level in the treatment groups, especially for the GDNF+OECs group (p<0.01 versus Control and p<0.05 versus GDNF groups; Figure 2C); it then decreased gradually (Figure 3).
Positive_regulation (restored) of Gene_expression (groups) of GDNF associated with injury
15) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.84 Pain Relevance 0
At 1 week after injury, the latency was almost restored to the pre-injury level in the treatment groups, especially for the GDNF+OECs group (p<0.01 versus Control and p<0.05 versus GDNF groups; Figure 2C); it then decreased gradually (Figure 3).
Positive_regulation (restored) of Gene_expression (groups) of GDNF associated with injury
16) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.84 Pain Relevance 0
Subsequently, GDNF protein levels gradually started to recover and surpassed the control level in the rostral stumps at 21 dpo, which may be explained by (1) GDNF transport within axons was strengthened, (2) inflammation leads to the increase of GDNF synthesis [36], and (3) induction of de novo synthesis of GDNF by neurons and/or non-neuronal cells.
Positive_regulation (increase) of Gene_expression (synthesis) of GDNF in neuronal associated with inflammation
17) Confidence 0.41 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.64 Pain Relevance 0.20
By combined in situ hybridization and immunohistochemistry we found that, in the dorsal root ganglia, CGRP was up-regulated specifically in neurons expressing GDNF but not NGF receptors following GDNF treatment.
Positive_regulation (up-regulated) of Neg (not) Gene_expression (expressing) of GDNF in neurons associated with nerve growth factor and calcitonin gene-related peptide
18) Confidence 0.38 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14656320 Disease Relevance 0.40 Pain Relevance 0.88
Although the levels of both NGF and GDNF were increased by inflammation, NGF rapidly and transiently increased whereas GDNF increased gradually over a period of approximately one week.
Positive_regulation (increased) of Gene_expression (levels) of GDNF associated with inflammation
19) Confidence 0.35 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525272 Disease Relevance 0.82 Pain Relevance 0.58
NGF and GDNF induced pErk1/2 kinetics differ on a single cell base
Positive_regulation (induced) of Gene_expression (/) of GDNF
20) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0

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