INT79986

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Context Info
Confidence 0.03
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) lyase activity (GAD1)
extracellular region (Gdnf) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
neurons 2
Gdnf (Rattus norvegicus)
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Projection neuron 1 83.72 Quite High
enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 3 100.00 Very High Very High Very High
Frailty 1 100.00 Very High Very High Very High
Neurodegenerative Disease 1 64.20 Quite High
Disease 1 5.00 Very Low Very Low Very Low
Multiple System Atrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GDNF selectively prevented: (i) the loss of a subpopulation of striatonigral neurons expressing GAD and PPTA; (ii) the atrophy of PPTA-positive neurons; and (iii) the decrease in GAD, PPTA and DYN mRNA expression, after QUIN injection.
GDNF Negative_regulation (prevented) of Gene_expression (expression) of GAD in neurons associated with generalized anxiety disorder and frailty
1) Confidence 0.03 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 9987028 Disease Relevance 0.46 Pain Relevance 0.04

General Comments

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