INT79993

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
plaque 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 14 79.64 Quite High
cva 3 68.92 Quite High
Inflammation 2 10.40 Low Low
Pain 7 5.00 Very Low Very Low Very Low
beta blocker 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 2 99.56 Very High Very High Very High
Pressure And Volume Under Development 6 98.26 Very High Very High Very High
Cardiovascular Disease 7 91.76 High High
Rupture 3 82.72 Quite High
Atherosclerosis 34 74.64 Quite High
Jaundice 1 70.36 Quite High
Injury 3 69.84 Quite High
Thrombosis 1 69.24 Quite High
Peripheral Arterial Disease 61 50.00 Quite Low
Sarcoidosis 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Positive_regulation (contributes) of Positive_regulation (accumulation) of ACE in plaque associated with atherosclerotic plaque and pressure and volume under development
1) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.71 Pain Relevance 0.10
Together with these findings an increased activity of the angiotensin-converting-enzyme (ACE) indicated sarcoidosis, other causes having been excluded.
Positive_regulation (increased) of Positive_regulation (activity) of ACE
2) Confidence 0.45 Published 1999 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9987484 Disease Relevance 0.07 Pain Relevance 0

General Comments

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