INT80005

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Context Info
Confidence 0.09
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.79
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MVK) small molecule metabolic process (MVK) peroxisome (MVK)
cytoplasm (MVK)
Anatomy Link Frequency
monocytes 1
cerebral cortex 1
kidney 1
MVK (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 2 99.36 Very High Very High Very High
rheumatoid arthritis 7 86.44 High High
cytokine 68 86.00 High High
Inflammation 24 83.60 Quite High
Opioid 4 77.28 Quite High
antagonist 11 76.72 Quite High
methotrexate 2 75.92 Quite High
narcan 4 75.76 Quite High
orphanin 10 75.00 Quite High
opioid receptor 4 69.24 Quite High
Disease Link Frequency Relevance Heat
Syndrome 7 98.36 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 96.24 Very High Very High Very High
Cryopyrin-associated Periodic Syndromes 1 95.24 Very High Very High Very High
Castlemans Disease 1 92.04 High High
Hyperplasia 1 89.60 High High
Disease 27 87.20 High High
Rheumatoid Arthritis 7 86.44 High High
INFLAMMATION 27 83.60 Quite High
Bacterial Respiratory Disease 1 77.96 Quite High
Rickettsiaceae Infection 1 77.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Gene_expression (/) of MVK associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
1) Confidence 0.09 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.79 Pain Relevance 0.18
A semi-nested reverse transcriptase-polymerase chain reaction survey of receptor mRNA indicates that it is expressed in the porcine cerebral cortex and kidney, and along the length of the gastrointestinal tract.
Gene_expression (expressed) of receptor mRNA in cerebral cortex associated with cerebral cortex
2) Confidence 0.01 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988113 Disease Relevance 0 Pain Relevance 0.55
Human monocytes demonstrate a change in receptor functionality without a corresponding change in the level of receptor mRNA expression, suggesting that receptor function can be regulated via posttranslational mechanisms [16].
Gene_expression (expression) of receptor mRNA in monocytes
3) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.07
A semi-nested reverse transcriptase-polymerase chain reaction survey of receptor mRNA indicates that it is expressed in the porcine cerebral cortex and kidney, and along the length of the gastrointestinal tract.
Gene_expression (expressed) of receptor mRNA in kidney associated with cerebral cortex
4) Confidence 0.00 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988113 Disease Relevance 0 Pain Relevance 0.55

General Comments

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