INT80006

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 4
Speculated 6
Reported most in Body
Documents 8
Total Number 14
Disease Relevance 3.75
Pain Relevance 9.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 6
brain 4
CeA 3
spinal 2
spinal cord dorsal horn 2
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 180 100.00 Very High Very High Very High
Glutamate 64 100.00 Very High Very High Very High
Inflammation 48 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
Glutamate receptor 9 100.00 Very High Very High Very High
intrathecal 8 100.00 Very High Very High Very High
Lasting pain 14 99.84 Very High Very High Very High
Nucleus accumbens 20 99.80 Very High Very High Very High
qutenza 8 99.76 Very High Very High Very High
spinal dorsal horn 4 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 49 100.00 Very High Very High Very High
Pain 28 99.84 Very High Very High Very High
Nociception 56 99.64 Very High Very High Very High
Brain Hemorrhage 38 98.60 Very High Very High Very High
Urological Neuroanatomy 2 97.00 Very High Very High Very High
Injury 39 95.60 Very High Very High Very High
Neuropathic Pain 34 93.04 High High
Attention Deficit Hyperactivity Disorder 1 92.96 High High
Drug Dependence 3 87.64 High High
Frailty 8 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of intrathecal injection of prednisolone acetate on expression of NR2B subunit and nNOS in spinal cord of rats after chronic compression of dorsal root ganglia.
Regulation (Effects) of Gene_expression (expression) of NR2B in spinal cord associated with spinal cord and intrathecal
1) Confidence 0.57 Published 2007 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 18000292 Disease Relevance 0.31 Pain Relevance 0.70
We used immunohistochemistry and immunoblotting to investigate the effect of ifenprodil on NR2B subunits expression in CCD rats.
Spec (investigate) Regulation (effect) of Gene_expression (expression) of NR2B in CCD
2) Confidence 0.54 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19224818 Disease Relevance 0.08 Pain Relevance 0
The effects of a specific inhibitor of PP2A, fostriecin, on the expression of NR1, phospho-NR1, NR2B, and phospho-NR2B subunits of the NMDA receptor in the spinal cord of rats following noxious stimulation were examined.
Spec (examined) Regulation (effects) of Gene_expression (expression) of NR2B in spinal cord associated with nmda receptor and spinal cord
3) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15919130 Disease Relevance 0 Pain Relevance 0.69
However, NR2B expression was depressed by 24 hours following the carrageenan inflammation and did not recover during the 5 day period examined.
Neg (not) Spec (examined) Regulation (recover) of Gene_expression (expression) of NR2B associated with inflammation
4) Confidence 0.42 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.80 Pain Relevance 0.27
The loss of NR2B subunits in the spinal cord as the nociceptive stimulus progresses suggests that pharmacological agents targeting NR2B may be less effective in chronic pain than in acute pain.
Spec (may) Regulation (effective) of Gene_expression (targeting) of NR2B in spinal cord associated with nociception, acute pain, lasting pain and spinal cord
5) Confidence 0.42 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 1.09 Pain Relevance 0.84
To elucidate how glucocorticoids affect this mechanism, we studied the effects of intrathecal (it) injection of prednisolone acetate (PA) on a nociceptive stimulus and the changes of nNOS and NR2B subunit expression in the spinal dorsal horn of Sprague Dawley rats following chronic compression of the dorsal root ganglia (CCD).
Regulation (changes) of Gene_expression (expression) of NR2B in spinal associated with nociception, spinal dorsal horn and intrathecal
6) Confidence 0.42 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.34 Pain Relevance 0.68
However, no change in the levels of NR1, NR2A, and NR2B subunits was observed in slices treated with 1 ┬ÁM UCB for 24 h.
Neg (no) Regulation (change) of Gene_expression (levels) of NR2B
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0 Pain Relevance 0.36
The expression of the NR2B subunit was unchanged in all regions examined.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of NR2B
8) Confidence 0.41 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17321516 Disease Relevance 0.19 Pain Relevance 1.10
RESULTS: Long-term morphine infusion induced antinociceptive tolerance and up-regulated N-methyl-d-aspartate receptor subunits NR1 and NR2B expression in both total lysate and synaptosome fraction of the spinal cord dorsal horn.
Regulation (regulated) of Gene_expression (expression) of NR2B in spinal cord dorsal horn
9) Confidence 0.38 Published 2010 Journal Anesthesiology Section Body Doc Link 20938337 Disease Relevance 0 Pain Relevance 0
Altered expression of NR2A and NR2B, which depends on the duration of focal cerebral ischemia, could play variable roles in secondary brain cell injury in the penumbra
Regulation (Altered) of Gene_expression (expression) of NR2B in brain associated with brain hemorrhage, ischemia and injury
10) Confidence 0.33 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.45 Pain Relevance 0.25
In this study we examined the effects of chronic morphine administration on gene and protein expression of three major NMDA receptors subunits (NR1, NR2A, and NR2B) in NAcc and CeA.
Spec (examined) Regulation (effects) of Gene_expression (expression) of NR2B in CeA associated with nucleus accumbens, nmda receptor, amygdala and morphine
11) Confidence 0.26 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453311 Disease Relevance 0.09 Pain Relevance 1.51
Expression of ionotropic glutamate receptor subunits NR2A, NR2B and GluR2, and of the vesicular glutamate transporter VGLUT1 was also previously shown not to be altered by CNTF [12].
Regulation (altered) of Gene_expression (Expression) of NR2B associated with glutamate and glutamate receptor
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.13 Pain Relevance 0.53
In this study we examined the effects of chronic morphine administration on gene and protein expression of three major NMDA receptors subunits (NR1, NR2A, and NR2B) in NAcc and CeA.
Spec (examined) Regulation (effects) of in NAcc Gene_expression (expression) of NR2B in CeA associated with nucleus accumbens, nmda receptor, amygdala and morphine
13) Confidence 0.09 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453311 Disease Relevance 0.09 Pain Relevance 1.51
The expression of NR2A and NR2B subunit mRNAs did not change after morphine treatment in any brain region.
Neg (not) Regulation (change) of Gene_expression (expression) of NR2B in brain associated with morphine
14) Confidence 0.04 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 1.19

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