INT80024

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Context Info
Confidence 0.04
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KLRD1)
Anatomy Link Frequency
T cell 2
regulatory T cells 1
KLRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 3 95.56 Very High Very High Very High
local anesthetic 8 91.20 High High
rheumatoid arthritis 1 78.32 Quite High
Multiple sclerosis 1 62.16 Quite High
Angina 2 50.00 Quite Low
spinal inflammation 14 37.88 Quite Low
Inflammation 3 22.16 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 1 97.76 Very High Very High Very High
Autoimmune Disease 8 81.28 Quite High
Rheumatoid Arthritis 1 78.32 Quite High
Diabetes Mellitus 2 76.56 Quite High
Systemic Lupus Erythematosus 1 74.48 Quite High
Thyroiditis 1 71.76 Quite High
Drug Hypersensitivity 1 69.92 Quite High
Cv General 3 Under Development 2 62.92 Quite High
Demyelinating Disease 1 62.16 Quite High
Disease 12 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulatory compounds induced a down-regulation of the T cell receptor, demonstrating that these non-peptide antigens are recognized by the T cell receptor itself.
Negative_regulation (down-regulation) of cell receptor in T cell
1) Confidence 0.04 Published 1999 Journal J. Invest. Dermatol. Section Abstract Doc Link 9989796 Disease Relevance 0.17 Pain Relevance 0.81
This is associated with downregulation of early T cell receptor signaling that results in an increase in autoreactive T cells and autoantibody production, a process thought to be due to defective deletion of autoreactive T cells during thymic maturation or dysfunction of regulatory T cells [6].
Negative_regulation (downregulation) of cell receptor in regulatory T cells
2) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2632733 Disease Relevance 0.68 Pain Relevance 0.07
As T cell receptor down-regulation or apoptosis after natural killer T cell activation and subsequent interferon-gamma release may contribute to atherogenesis, natural killer T cells can become a novel therapeutic target for the prevention and treatment of atherosclerotic vascular diseases.


Negative_regulation (down-regulation) of cell receptor in T cell
3) Confidence 0.01 Published 2006 Journal Coron. Artery Dis. Section Body Doc Link 16905964 Disease Relevance 0.06 Pain Relevance 0

General Comments

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