INT80025

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.41
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MIB1) ligase activity (MIB1) cytoplasm (MIB1)
Anatomy Link Frequency
ganglion 1
MIB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 8 99.98 Very High Very High Very High
Pain 3 93.20 High High
imagery 3 91.32 High High
headache 3 89.44 High High
Central nervous system 1 75.00 Quite High
Lasting pain 1 50.84 Quite High
Spinal cord 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.98 Very High Very High Very High
Malignant Neoplastic Disease 27 99.68 Very High Very High Very High
Brain Tumor 6 99.56 Very High Very High Very High
Necrosis 3 98.78 Very High Very High Very High
Rhabdoid Tumor 7 98.72 Very High Very High Very High
Hyperplasia 1 98.02 Very High Very High Very High
Cancer 45 96.20 Very High Very High Very High
Apoptosis 1 94.56 High High
Giant Cell Tumors 23 94.48 High High
Disease 1 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The conclusions are as follows: (1) histologic appearance and MIB-1 indices were not reliably predictive of tumor behavior, probably due in part to tumor heterogeneity; (2) tumors with two or more of the following features: identifiable mitotic figures, hypercellularity, vascular proliferation, and necrosis were more likely to behave in an aggressive manner; and (3) elevated MIB-1 labeling indices (>/=4.0 in this study) were encountered in a higher percentage of fatal and recurrent tumors than in nonfatal or nonrecurrent tumors.
Positive_regulation (elevated) of MIB-1 associated with necrosis, cancer and hyperplasia
1) Confidence 0.40 Published 1999 Journal Ann Diagn Pathol Section Abstract Doc Link 9990108 Disease Relevance 1.75 Pain Relevance 0
She underwent gross-total resection and the findings of the surgical pathological report were consistent with an RM, with a dramatically elevated MIB-1 index of approximately 50%.
Positive_regulation (elevated) of MIB-1 associated with brain tumor
2) Confidence 0.40 Published 2005 Journal J. Neurosurg. Section Abstract Doc Link 15739568 Disease Relevance 1.10 Pain Relevance 0.23
A lesion adjacent to the DRG increases MIB-1 activity, indicating proliferation and regeneration after 2 weeks, despite the fact that the lesion was made outside the ganglion.
Positive_regulation (increases) of MIB-1 in ganglion associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.33 Published 2001 Journal Eur J Pain Section Abstract Doc Link 11465982 Disease Relevance 0.67 Pain Relevance 0.31
Also, Mib-1 staining is low in the benign component and significantly increased in the malignant component (Figures 5E, F).


Positive_regulation (increased) of Mib-1 associated with malignant neoplastic disease
4) Confidence 0.25 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954972 Disease Relevance 0.83 Pain Relevance 0
Our case is the first MRT case immunopositive for HMB-45 and has also shown that the MRT cells grow aggressive over time as demonstrated by a four-fold increase in MIB-1 labeling index.
Positive_regulation (increase) of MIB-1 associated with rhabdoid tumor
5) Confidence 0.05 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 15980975 Disease Relevance 1.06 Pain Relevance 0.09

General Comments

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