INT80030

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FAS, TNF) extracellular region (FAS, TNF) plasma membrane (FAS, TNF)
aging (FAS) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
pore 1
FAS (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 98.74 Very High Very High Very High
Multiple sclerosis 1 95.92 Very High Very High Very High
Inflammation 1 73.52 Quite High
Dopamine 1 47.52 Quite Low
agonist 1 46.80 Quite Low
Nerve growth factor 3 25.00 Low Low
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 8 99.72 Very High Very High Very High
Disease 1 98.52 Very High Very High Very High
INFLAMMATION 4 97.76 Very High Very High Very High
Death 15 96.64 Very High Very High Very High
Demyelinating Disease 1 95.92 Very High Very High Very High
Neurodegenerative Disease 4 94.32 High High
Apoptosis 9 92.04 High High
Stress 1 74.16 Quite High
Toxicity 1 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell surface receptors (e.g., CD95/APO-1/Fas; TNF receptor) and their ligands (CD95-L; TNF) as well as evolutionarily conserved mechanisms involving proteases, mitochondrial factors (e.g. , Bcl-2-related proteins, reactive oxygen species, mitochondrial membrane potential, opening of the permeability transition pore) or p53 participate in the modulation and execution of cell death.
CD95 Binding (ligands) of TNF in pore associated with death
1) Confidence 0.27 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060707 Disease Relevance 0.93 Pain Relevance 0.08
NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species.
Fas Binding (ligation) of TNF-alpha associated with colon cancer and cinod
2) Confidence 0.26 Published 1999 Journal Biochim. Biophys. Acta Section Title Doc Link 9990295 Disease Relevance 0.80 Pain Relevance 0.25
Neither TNF-alpha nor Fas ligation alter basal or chemopreventive agent-activated ROS generation, suggesting that the death ligands and chemopreventive agents act in a complementary fashion.
Fas Neg (Neither) Binding (ligation) of TNF-alpha associated with death
3) Confidence 0.20 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.81 Pain Relevance 0.22

General Comments

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