INT80033

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 41.19
Pain Relevance 5.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
T cells 5
B-cell 2
lymph nodes 1
plasma 1
macrophages 1
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 261 99.32 Very High Very High Very High
qutenza 17 98.94 Very High Very High Very High
Morphine 9 98.88 Very High Very High Very High
cva 9 98.60 Very High Very High Very High
cINOD 32 98.46 Very High Very High Very High
fibrosis 100 98.28 Very High Very High Very High
Inflammatory response 26 97.88 Very High Very High Very High
Multiple sclerosis 17 97.60 Very High Very High Very High
endometriosis 99 94.96 High High
rheumatoid arthritis 60 91.36 High High
Disease Link Frequency Relevance Heat
Death 298 100.00 Very High Very High Very High
Syndrome 120 100.00 Very High Very High Very High
Stroke 12 100.00 Very High Very High Very High
Apoptosis 808 99.98 Very High Very High Very High
Broca Aphasia 60 99.76 Very High Very High Very High
Brain Injury 10 99.56 Very High Very High Very High
Colon Cancer 24 99.44 Very High Very High Very High
Autoimmune Lymphoproliferative Syndrome 6 99.42 Very High Very High Very High
Infection 200 99.24 Very High Very High Very High
Lymphadenopathy 2 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 34% of these cases, FAS was also associated with agrammatism.
FAS Binding (associated) of associated with syndrome and broca aphasia
1) Confidence 0.48 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1774568 Disease Relevance 1.89 Pain Relevance 0.17
The T-cell apoptosis induced by Fas/FasL binding serves to down-regulate the immune response to antigens.
Fas Binding (binding) of in T-cell associated with apoptosis
2) Confidence 0.47 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.45 Pain Relevance 0.13
Analysis of the tissue following treatment demonstrated that synoviocytes and mononuclear cells present in the tissue had been eliminated by apoptosis through a Fas/FasL interaction [106].
Fas Binding (interaction) of in mononuclear cells associated with apoptosis
3) Confidence 0.47 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.38 Pain Relevance 0.37
Apoptosis, or programmed cell death, and the elimination of apoptotic cells are crucial factors in the maintenance of liver health Apoptosis allows hepatocytes to die without provoking a potentially harmful inflammatory response In contrast to necrosis, apoptosis is tightly controlled and regulated via several mechanisms, including Fas/Fas ligand interactions, the effects of cytokines such as tumor necrosis factor alpha (TNF-alpha) and transforming growth factor beta (TGF-beta), and the influence of pro- and antiapoptotic mitochondria-associated proteins of the B-cell lymphoma-2 (Bcl-2) family.
Fas Binding (interactions) of in B-cell associated with necrosis, inflammatory response, lymphatic system cancer, cancer, apoptosis and cytokine
4) Confidence 0.47 Published 2001 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 11347718 Disease Relevance 1.54 Pain Relevance 0.10
Apoptosis, or programmed cell death, and the elimination of apoptotic cells are crucial factors in the maintenance of liver health Apoptosis allows hepatocytes to die without provoking a potentially harmful inflammatory response In contrast to necrosis, apoptosis is tightly controlled and regulated via several mechanisms, including Fas/Fas ligand interactions, the effects of cytokines such as tumor necrosis factor alpha (TNF-alpha) and transforming growth factor beta (TGF-beta), and the influence of pro- and antiapoptotic mitochondria-associated proteins of the B-cell lymphoma-2 (Bcl-2) family.
Fas Binding (interactions) of in B-cell associated with necrosis, inflammatory response, lymphatic system cancer, cancer, apoptosis and cytokine
5) Confidence 0.47 Published 2001 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 11347718 Disease Relevance 1.54 Pain Relevance 0.10
The antioxidant N-acetylcysteine (NAC) blocks cell death and NF-kappa B activation induced by Fas ligation, suggesting a potential role for NF-kappa B in Fas-induced apoptosis in these cells.
Fas Binding (ligation) of associated with apoptosis and death
6) Confidence 0.40 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.91 Pain Relevance 0.29
We therefore conclude that in this patient, as in few other reported cases, the FAS is associated with agrammatism as a direct consequence of a cerebral infarct.


FAS Binding (associated) of associated with cv general 4 under development, syndrome and broca aphasia
7) Confidence 0.37 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1774568 Disease Relevance 1.05 Pain Relevance 0.16
In addition, cholesterol-enriched micro-domains, so called lipid rafts, are important signal transduction platforms [24], which have been related to apoptosis [25] and changes in plasma cholesterol levels have been associated with Fas-FADD complex formation and caspase-8 activation [26], [27].
Fas Binding (associated) of in plasma associated with apoptosis
8) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671171 Disease Relevance 0.62 Pain Relevance 0
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand has been proposed for inhibition on cell growth and induction of apoptosis in human hepatoma cells by saikosaponin d [7].
Fas Binding (ligand) of associated with hepatocellular cancer and apoptosis
9) Confidence 0.36 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 1.24 Pain Relevance 0.13
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand has been proposed for inhibition on cell growth and induction of apoptosis in human hepatoma cells by saikosaponin d [7].
Fas Binding (ligand) of associated with hepatocellular cancer and apoptosis
10) Confidence 0.36 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 1.24 Pain Relevance 0.13
CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.
Fas Binding (independent) of associated with qutenza and death
11) Confidence 0.36 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.99 Pain Relevance 0.55
CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.
CD95 Binding (independent) of associated with qutenza and death
12) Confidence 0.36 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.99 Pain Relevance 0.55
Since 1988, intravenous immunoglobulin (IVIG) has been shown to interfere with the interaction of Fas and FasL, and can be used as a treatment for TEN.
Fas Binding (interaction) of
13) Confidence 0.36 Published 2006 Journal Semin Cutan Med Surg Section Abstract Doc Link 16908399 Disease Relevance 0.74 Pain Relevance 0.07
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of apoptosis associated most often with heritable FAS mutations leading to lymphadenopathy, hypersplenism and chronic refractory autoimmune cytopenias.
FAS Binding (associated) of associated with lymphadenopathy, hypersplenism, apoptosis and autoimmune lymphoproliferative syndrome
14) Confidence 0.36 Published 2005 Journal Br. J. Haematol. Section Abstract Doc Link 15877736 Disease Relevance 0.66 Pain Relevance 0
The Fas/(FasL) system has been recognized as a major pathway for the induction of apoptosis in cells and tissues.
Fas Binding (recognized) of associated with apoptosis
15) Confidence 0.35 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.42 Pain Relevance 0.14
When FasR binds its ligand, namely Fas ligand (FasL), a cascade of events follows, including caspase activation, ultimately eventuating in cellular death.
Fas Binding (binds) of associated with death
16) Confidence 0.35 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503670 Disease Relevance 1.23 Pain Relevance 0.08
Normally, BCC cells fail to express FasR, thus preventing cell apoptosis via FasR-Fas ligand interaction (Berman et al 2003; Ceilley and Del Rosso 2006).


Fas Binding (interaction) of associated with apoptosis and basal cell carcinoma
17) Confidence 0.35 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503670 Disease Relevance 1.17 Pain Relevance 0
Antitumor activity against glioma was also found in mice treated with IL-18 and IL-12 via Semliki Forest virus [154,155] or with a combination of IL-18 and Fas [156].
Fas Binding (combination) of associated with glioma
18) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.83 Pain Relevance 0.11
This lymphocyte apoptosis is likely to involve several pathways, but we show that apoptosis via Fas/FasL interaction is largely responsible for the massive lymphocyte death observed in human fatal ZEBOV infection.
Fas Binding (interaction) of in lymphocyte associated with apoptosis, infection and death
19) Confidence 0.35 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 1.67 Pain Relevance 0
Clonally expanded T cells that have served their functional purpose are also cleared from the system through activation induced cell death (AICD) involving cell surface FasL/Fas receptor interaction [13].
Fas Spec (cleared) Binding (interaction) of in T cells associated with death
20) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.47 Pain Relevance 0.19

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