INT80034

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 30.34
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
T cells 10
lymph node 4
plasma 4
RT4 4
apoptotic cells 2
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 45 99.98 Very High Very High Very High
fibrosis 80 99.60 Very High Very High Very High
Endogenous opioid 3 99.34 Very High Very High Very High
cytokine 242 99.28 Very High Very High Very High
Dopamine 7 99.12 Very High Very High Very High
Arthritis 132 96.52 Very High Very High Very High
Inflammation 282 96.12 Very High Very High Very High
Inflammatory response 21 96.08 Very High Very High Very High
Nerve growth factor 5 95.40 Very High Very High Very High
cINOD 21 94.08 High High
Disease Link Frequency Relevance Heat
Death 160 100.00 Very High Very High Very High
Apoptosis 625 99.68 Very High Very High Very High
Pulmonary Fibrosis 63 99.60 Very High Very High Very High
Infection 306 99.56 Very High Very High Very High
Aging 321 99.12 Very High Very High Very High
Disease 193 98.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 101 98.04 Very High Very High Very High
Renal Cancer 5 97.52 Very High Very High Very High
Colon Cancer 16 97.38 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 16 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the levels of TNF-alpha receptor R1 (TNF-R1, p55), bcl-2, soluble Fas (sFas), and the activities of caspase-1 and caspase-3 were also elevated in the nigrostriatal DA regions in PD.
Positive_regulation (elevated) of Gene_expression (levels) of Fas associated with dopamine and disease
1) Confidence 0.67 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.16 Pain Relevance 0.63
Notably, ATM activation was also found to control upregulation of Fas/CD95 expression and its co-clustering with TRPV1 as well as RT4 cell growth and apoptosis.
Positive_regulation (upregulation) of Gene_expression (expression) of Fas in RT4 associated with apoptosis
2) Confidence 0.67 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.89 Pain Relevance 0.48
After 24 weeks, a decrease in the number of mast cells and the enhanced expression of Fas antigen by lesional fibroblasts were observed.
Positive_regulation (enhanced) of Gene_expression (expression) of Fas in mast cells
3) Confidence 0.67 Published 2003 Journal J Dermatolog Treat Section Abstract Doc Link 14660274 Disease Relevance 1.13 Pain Relevance 0.45
The dual chemopreventive agent/death ligand treatments do not increase Fas, TNF receptor 1, Bak or c-myc expression (although salicylic acid moderately induces of Fas expression).
Positive_regulation (induces) of Gene_expression (expression) of Fas associated with death
4) Confidence 0.57 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.94 Pain Relevance 0.23
The dual chemopreventive agent/death ligand treatments do not increase Fas, TNF receptor 1, Bak or c-myc expression (although salicylic acid moderately induces of Fas expression).
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of Fas associated with death
5) Confidence 0.57 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.94 Pain Relevance 0.23
We have previously shown that morphine induces Fas expression and promotes Fas-mediated apoptosis.
Positive_regulation (induces) of Gene_expression (expression) of Fas associated with apoptosis and morphine
6) Confidence 0.51 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 0.88 Pain Relevance 0.66
Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis.
Positive_regulation (increasing) of Gene_expression (expression) of Fas in lymphocytes associated with endogenous opioid, apoptosis and death
7) Confidence 0.49 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615182 Disease Relevance 0.95 Pain Relevance 0.27
These include, the prominence of the PI3K/PTEN/Akt cell survival pathway [113, 114], upregulation of HSP70 gene expression [115], suppressed Fas/CD95-mediated signaling [116], activation of NF-?
Positive_regulation (upregulation) of Gene_expression (suppressed) of Fas
8) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.41 Pain Relevance 0.43
In addition, combination treatment with As2O3 and sulindac increased the catalytic activity of caspase-3, -8, and -9 along with induction of Fas/FasL expression and cytosolic release of cytochrome c.
Positive_regulation (induction) of Gene_expression (expression) of Fas
9) Confidence 0.49 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685442 Disease Relevance 0.56 Pain Relevance 0.15
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of Fas
10) Confidence 0.49 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.76 Pain Relevance 0.34
These include, the prominence of the PI3K/PTEN/Akt cell survival pathway [113, 114], upregulation of HSP70 gene expression [115], suppressed Fas/CD95-mediated signaling [116], activation of NF-?
Positive_regulation (upregulation) of Gene_expression (suppressed) of CD95
11) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.41 Pain Relevance 0.43
Notably, ATM activation was also found to control upregulation of Fas/CD95 expression and its co-clustering with TRPV1 as well as RT4 cell growth and apoptosis.
Positive_regulation (upregulation) of Gene_expression (expression) of CD95 in RT4 associated with apoptosis
12) Confidence 0.49 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.89 Pain Relevance 0.48
The percentage of apoptotic cells were then evaluated using the APO-BRDU terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) assay according to the manufacturer's instructions (Sigma, St.
Positive_regulation (evaluated) of Gene_expression (using) of APO in apoptotic cells associated with apoptosis
13) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.72 Pain Relevance 0
Furthermore, RT-PCR analysis revealed that morphine and LPS up-regulated Fas expression.
Positive_regulation (up-regulated) of Gene_expression (expression) of Fas associated with morphine
14) Confidence 0.48 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14698842 Disease Relevance 0.34 Pain Relevance 0.62
Two early reversible morphological features of apoptosis signal cascade activation, phosphatidylserine externalization and Fas expression in the plasma membrane, increased after reperfusion in the ModHT group but not in MiHT patients.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Fas in plasma associated with apoptosis
15) Confidence 0.46 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 1.00 Pain Relevance 0
Long treatment periods result in enhancement of Fas-dependent apoptosis associated with an overexpression of Fas and Fas ligand, and a central role in Bcl-2 inhibition [55].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Fas associated with apoptosis
16) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.74 Pain Relevance 0.04
Fas expression did not change in the presence of healthy plasma (Figure 4C), whereas it was markedly up-regulated with burns septic ARF group plasma (Figure 4D).
Neg (not) Positive_regulation (change) of Gene_expression (expression) of Fas in plasma associated with acute renal failure and burns
17) Confidence 0.38 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.66 Pain Relevance 0
Morphine-induced apoptosis was inhibited by transfection with a dominant negative Fas-associated death domain (FADD) plasmid, revealing that morphine-induced apoptosis is dependent on FADD.
Positive_regulation (transfection) of Gene_expression (transfection) of Fas associated with apoptosis, death and morphine
18) Confidence 0.37 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529824 Disease Relevance 1.07 Pain Relevance 0.82
We previously showed that morphine enhances Fas death receptor expression in a T cell hybridoma and human PBL.
Positive_regulation (enhances) of Gene_expression (expression) of Fas in T cell associated with death and morphine
19) Confidence 0.33 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.65 Pain Relevance 0.70
A higher Fas expression was observed after reperfusion in ModHT patients, but not in those operated under mild hypothermia, which tended to show less Fas positive cells after weaning from CPB.
Positive_regulation (higher) of Gene_expression (expression) of Fas associated with hypothermia
20) Confidence 0.33 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.76 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox