INT80036

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 42.22
Pain Relevance 9.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
plasma 3
T cells 2
synovial fluid 1
hepatocytes 1
cardiomyocytes 1
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 2 100.00 Very High Very High Very High
qutenza 34 99.98 Very High Very High Very High
rheumatoid arthritis 82 99.84 Very High Very High Very High
Morphine 21 99.80 Very High Very High Very High
Crohn's disease 16 99.58 Very High Very High Very High
antagonist 50 99.20 Very High Very High Very High
Inflammation 461 99.12 Very High Very High Very High
fibrosis 214 98.68 Very High Very High Very High
alcohol 86 98.40 Very High Very High Very High
chemokine 66 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1214 100.00 Very High Very High Very High
Death 316 100.00 Very High Very High Very High
Syndrome 92 100.00 Very High Very High Very High
Fetal Alcohol Syndrome 18 100.00 Very High Very High Very High
Rheumatoid Arthritis 83 99.84 Very High Very High Very High
Broca Aphasia 40 99.80 Very High Very High Very High
Cancer 519 99.76 Very High Very High Very High
Acute Renal Failure 249 99.72 Very High Very High Very High
Staphylococcus Infection 128 99.66 Very High Very High Very High
Ovarian Cancer 14 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced CD95 (Fas) upregulation, and diminished cytolytic activity, but to a significant increase in anti-dsDNA antibodies [70].
Positive_regulation (upregulation) of Fas
1) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374473 Disease Relevance 0.77 Pain Relevance 0.12
We showed that Phenoxodiol has activity as a single agent in patient-derived, chemotherapy-resistant ovarian cancer cell lines, via induction of Fas-mediated apoptosis.
Positive_regulation (induction) of Fas associated with ovarian cancer and apoptosis
2) Confidence 0.67 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.18 Pain Relevance 0
CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.
Positive_regulation (upregulation) of Fas associated with qutenza and death
3) Confidence 0.67 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 1.00 Pain Relevance 0.55
CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.
Positive_regulation (upregulation) of CD95 associated with qutenza and death
4) Confidence 0.67 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.99 Pain Relevance 0.55
In addition, several potential mechanisms are proposed for this antiangiogenic activity, including the generation of free radicals such as superanions and nitric oxide [26] and upregulation of the Fas/FASL system.
Positive_regulation (upregulation) of Fas
5) Confidence 0.67 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2862241 Disease Relevance 0.49 Pain Relevance 0.03
In parallel, semi-quantitative Western blot and flow cytometry analysis showed that U69593 caused a rapid but transient up-regulation of Fas protein, suggesting that its effect on apoptosis is mediated by activation of the Fas/FasL apoptotic pathway.
Positive_regulation (regulation) of Fas associated with apoptosis
6) Confidence 0.67 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517294 Disease Relevance 0.89 Pain Relevance 0.66
Morphine directly upregulates immune cell Fas receptors that trigger apoptosis of the cell when activated by the ligand FasL (Yin et al 1999).
Positive_regulation (upregulates) of Fas in immune cell associated with apoptosis and morphine
7) Confidence 0.49 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.24 Pain Relevance 1.47
IFX induces apoptosis of peripheral blood monocytes from healthy volunteers and patients with CD dose-dependently by activation of caspase-8, 9 and 3 in a Fas-independent manner 30.
Positive_regulation (activation) of Fas in monocytes associated with crohn's disease, infliximab and apoptosis
8) Confidence 0.49 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.86 Pain Relevance 1.02
Cytotoxic concentrations of DADLE, on the other hand, caused an increase of Fas-ligand (FasL) in PC12 cells that was attenuated by a selective mu antagonist.
Positive_regulation (increase) of Fas associated with antagonist
9) Confidence 0.49 Published 2002 Journal Synapse Section Abstract Doc Link 11746737 Disease Relevance 0.20 Pain Relevance 0.68
Carnitine decreases the number of apoptotic cells and lowers caspase 3-like activity in Jurkat T cells after stimulation of the death domain receptor Fas [49], in the serum-starved P19 teratoma cell line [50] and in cardiomyocytes exposed to doxorubicin [51].
Positive_regulation (stimulation) of Fas in cardiomyocytes associated with teratoma, apoptosis and death
10) Confidence 0.49 Published 2003 Journal Crit Care Section Body Doc Link PMC270672 Disease Relevance 0.82 Pain Relevance 0
RESULTS: Tumor cells up-regulated the surface molecules Fas (100% of cell lines up-regulated Fas), carcinoembryonic antigen (90%), mucin-1 (60%), MHC class I (50%), and intercellular adhesion molecule-1 (40%) in response to (153)Sm-EDTMP.
Positive_regulation (up-regulated) of Fas
11) Confidence 0.47 Published 2008 Journal Clin. Cancer Res. Section Body Doc Link 18594006 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Tumor cells up-regulated the surface molecules Fas (100% of cell lines up-regulated Fas), carcinoembryonic antigen (90%), mucin-1 (60%), MHC class I (50%), and intercellular adhesion molecule-1 (40%) in response to (153)Sm-EDTMP.
Positive_regulation (up-regulated) of Fas
12) Confidence 0.47 Published 2008 Journal Clin. Cancer Res. Section Body Doc Link 18594006 Disease Relevance 0.06 Pain Relevance 0
It appears clear now that increased levels of sFasL can be found in the serum of patients with SJS/TEN, and levels of sFasL are consistently elevated when analysis is performed preceding skin detachment [48].
Positive_regulation (elevated) of Fas in skin associated with staphylococcus infection and bullous skin disease
13) Confidence 0.45 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.35 Pain Relevance 0.04
To our knowledge, there are no instances of FAS and agrammatism previously reported in a bipolar patient.


Neg (no) Positive_regulation (instances) of FAS associated with syndrome and broca aphasia
14) Confidence 0.44 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1774568 Disease Relevance 1.18 Pain Relevance 0.07
We have reported the case of FG, a bipolar patient who presented with a sudden onset of FAS and agrammatism.
Positive_regulation (onset) of FAS associated with syndrome and broca aphasia
15) Confidence 0.44 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1774568 Disease Relevance 0.46 Pain Relevance 0.14
Concomitantly, we observed DR4, Fas(CD95) and caspase 8 activation, suggesting that these compounds activate both the mitochondrial and death receptor pathways working together to induce apoptosis.
Positive_regulation (activation) of CD95 associated with apoptosis and death
16) Confidence 0.42 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19846903 Disease Relevance 0.89 Pain Relevance 0.30
Concomitantly, we observed DR4, Fas(CD95) and caspase 8 activation, suggesting that these compounds activate both the mitochondrial and death receptor pathways working together to induce apoptosis.
Positive_regulation (activation) of Fas associated with apoptosis and death
17) Confidence 0.42 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19846903 Disease Relevance 0.89 Pain Relevance 0.30
The dual chemopreventive agent/death ligand treatments do not increase Fas, TNF receptor 1, Bak or c-myc expression (although salicylic acid moderately induces of Fas expression).
Neg (not) Positive_regulation (increase) of Fas associated with death
18) Confidence 0.41 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.93 Pain Relevance 0.23
Gene array analysis demonstrated that burns septic ARF group plasma induced an up-regulation of several pro-apoptotic genes such as Fas, Fas-Ligand (Fas-L), Bax and Bak and of positive regulators of apoptosis (Abl1, Gadd45a).
Positive_regulation (induced) of Fas in plasma associated with acute renal failure, burns and apoptosis
19) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.57 Pain Relevance 0.06
Gene array analysis demonstrated that burns septic ARF group plasma induced an up-regulation of several pro-apoptotic genes such as Fas, Fas-Ligand (Fas-L), Bax and Bak and of positive regulators of apoptosis (Abl1, Gadd45a).
Positive_regulation (induced) of Fas in plasma associated with acute renal failure, burns and apoptosis
20) Confidence 0.41 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.57 Pain Relevance 0.06

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