INT80038

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 13.93
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
fibroblasts 4
edge 4
colon 2
Hepa 1-6 2
embryonic kidney 2
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 168 99.82 Very High Very High Very High
cINOD 15 99.76 Very High Very High Very High
Analgesic 4 97.32 Very High Very High Very High
agonist 88 86.68 High High
ischemia 14 81.76 Quite High
imagery 10 66.64 Quite High
Inflammatory response 8 66.00 Quite High
Inflammation 36 58.28 Quite High
depression 13 56.68 Quite High
Spinal cord 5 54.48 Quite High
Disease Link Frequency Relevance Heat
Epstein-barr Virus 44 99.84 Very High Very High Very High
Diabetic Foot Ulcer 2 99.84 Very High Very High Very High
INFLAMMATION 47 99.66 Very High Very High Very High
Death 68 99.48 Very High Very High Very High
Breast Cancer 24 99.48 Very High Very High Very High
Thyroid Neoplasm 21 99.16 Very High Very High Very High
Decubitus Ulcers 64 98.80 Very High Very High Very High
Apoptosis 306 96.56 Very High Very High Very High
Lymphatic System Cancer 68 96.52 Very High Very High Very High
Hepatotoxicity 20 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This translocation results in c-myc overexpression and correlates with poor prognosis [183, 184].
Positive_regulation (results) of Gene_expression (overexpression) of c-myc
1) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.54 Pain Relevance 0
The epidermis of the non-healing edge of the pressure ulcers, as well as that of venous and diabetic foot ulcers, shows increased expression of c-myc and activation of nuclear ?
Positive_regulation (increased) of Gene_expression (expression) of c-myc in edge associated with diabetic foot ulcer and decubitus ulcers
2) Confidence 0.67 Published 2009 Journal World J Surg Section Body Doc Link PMC2691928 Disease Relevance 1.54 Pain Relevance 0.10
Neither acetaminophen nor E2 induced c-myc in MDA-MB-231 cells, whereas E2, but not acetaminophen, weakly induced c-myc expression in Ishikawa cells.
Positive_regulation (induced) of Gene_expression (expression) of c-myc in MDA-MB-231 associated with paracetamol
3) Confidence 0.67 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.33 Pain Relevance 0.90
Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity.
Positive_regulation (increases) of Gene_expression (expression) of c-myc associated with paracetamol and breast cancer
4) Confidence 0.67 Published 2002 Journal Toxicol. Sci. Section Title Doc Link 11896290 Disease Relevance 0.35 Pain Relevance 0.74
In contrast, the nonsteroidal anti-inflammatory drug, sulindac, increased c-myc expression, an effect attributable at least in part to its failure to induce transcriptional blockage.
Positive_regulation (increased) of Gene_expression (expression) of c-myc associated with inflammation and cinod
5) Confidence 0.67 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.38 Pain Relevance 0.10
The specific breakpoint locus differs between various forms of BL, there being a definite relation between the level of myc overexpression in BL and genomic breakpoint location within the myc locus [7], Halembiena et al having identified translocation breakpoints at 190 kb 5' and 50 kb 3' of myc [8].
Positive_regulation (overexpression) of Gene_expression (overexpression) of myc associated with epstein-barr virus
6) Confidence 0.51 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1934902 Disease Relevance 1.00 Pain Relevance 0
To generate Flp-In T-REx HEK-293 cell lines able to inducibly express c-Myc–I148E CXCR2–C352I Gi2?
Positive_regulation (inducibly) of Gene_expression (express) of c-Myc
7) Confidence 0.49 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.09 Pain Relevance 0
The epidermis of the non-healing edge of the pressure ulcers, as well as that of venous and diabetic foot ulcers, shows increased expression of c-myc and activation of nuclear ?
Positive_regulation (activation) of Gene_expression (expression) of c-myc in edge associated with diabetic foot ulcer and decubitus ulcers
8) Confidence 0.49 Published 2009 Journal World J Surg Section Body Doc Link PMC2691928 Disease Relevance 1.55 Pain Relevance 0.10
APAP has been demonstrated to induce c-Myc expression suggesting one means by which APAP may globally interfere with effects of recombinant IFN-?.
Positive_regulation (induce) of Gene_expression (expression) of c-Myc associated with paracetamol
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.06 Pain Relevance 0.66
In contrast, the nonsteroidal anti-inflammatory drug, sulindac, increased c-myc expression, an effect attributable at least in part to its failure to induce transcriptional blockage.
Positive_regulation (increased) of Gene_expression (expression) of c-myc associated with inflammation and cinod
10) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.38 Pain Relevance 0.10
Indomethacin reduces the proliferation rate and induces apoptosis in CaCo-2 colon cancer cells through enhanced expression of c-myc, p53, and p27 proteins.
Positive_regulation (enhanced) of Gene_expression (expression) of c-myc in colon
11) Confidence 0.49 Published 2001 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 11260862 Disease Relevance 0.13 Pain Relevance 0
We have found that APAP inhibits serum growth factor activation of c-myc expression, NF-kappaB DNA binding, and Raf kinase.
Positive_regulation (activation) of Gene_expression (expression) of c-myc associated with paracetamol
12) Confidence 0.49 Published 1999 Journal Toxicol. Sci. Section Abstract Doc Link 10353317 Disease Relevance 0.24 Pain Relevance 1.00
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.
Positive_regulation (activation) of Gene_expression (expression) of c-myc in Hepa 1-6 associated with paracetamol
13) Confidence 0.49 Published 1999 Journal Toxicol. Sci. Section Title Doc Link 10353317 Disease Relevance 0.28 Pain Relevance 1.03
The dual chemopreventive agent/death ligand treatments do not increase Fas, TNF receptor 1, Bak or c-myc expression (although salicylic acid moderately induces of Fas expression).
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of c-myc associated with death
14) Confidence 0.49 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9990295 Disease Relevance 0.94 Pain Relevance 0.23
Also of interest is the increase in MYC expression; this v-myc myelocytomatosis viral oncogene homolog functions as a transcription factor [48].
Positive_regulation (increase) of Gene_expression (expression) of MYC
15) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.28 Pain Relevance 0
increased c-Myc expression
Positive_regulation (increased) of Gene_expression (expression) of c-Myc
16) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.33 Pain Relevance 0.11
Under VPA treatment, transcription of c-myc is dependent upon JNK/SAPK, and ectopic expression of c-myc, leading to more resistant cells in cell cycle arrest, shows the importance of this protein in VPA-mediated activity.
Positive_regulation (dependent) of Gene_expression (expression) of c-myc
17) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.68 Pain Relevance 0.06
This translocation results in c-myc overexpression and correlates with poor prognosis [183, 184].
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-myc
18) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.53 Pain Relevance 0
For tr-FRET, 10 cm2 dishes of HEK (human embryonic kidney)-293 cells were transfected to express N-terminally c-Myc- or FLAG-tagged forms of hCXCR2 and/or hDOP individually or in combination.
Positive_regulation (transfected) of Gene_expression (express) of c-Myc in embryonic kidney
19) Confidence 0.45 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.03
O'Donnell et al. demonstrated that c-Myc activated expression of a set of 6 miRNAs on human chromosome 13 that was tied to the development of human lymphoma.
Positive_regulation (activated) of Gene_expression (expression) of Myc associated with lymphatic system cancer
20) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.83 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox