INT80041

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.00
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synovial fluids 1
Lip 1
microglia 1
hippocampus 1
Cd6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 130 99.48 Very High Very High Very High
Inflammatory response 13 98.44 Very High Very High Very High
Hippocampus 4 95.76 Very High Very High Very High
Inflammation 52 95.52 Very High Very High Very High
Arthritis 4 95.52 Very High Very High Very High
cerebral cortex 2 94.96 High High
tolerance 48 94.60 High High
Opioid 42 94.20 High High
Antinociceptive 10 89.24 High High
excitatory amino acid 2 86.96 High High
Disease Link Frequency Relevance Heat
Hypertrophy 8 99.30 Very High Very High Very High
Gliosis 24 98.62 Very High Very High Very High
INFLAMMATION 51 98.44 Very High Very High Very High
Cognitive Disorder 4 98.16 Very High Very High Very High
Arthritis 4 95.52 Very High Very High Very High
Nociception 20 95.04 Very High Very High Very High
Pain 20 78.80 Quite High
Temporomandibular Joint Syndrome 5 78.68 Quite High
Facial Nerve Injuries 2 78.64 Quite High
Neuropathic Pain 8 67.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The OX52 antibody to the rat CD6 antigen and the antibody to the T-Cell Receptor (TCR) produced identical surface staining of small rounded or oval cells about 4 ?
Gene_expression (antibody) of OX52
1) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.19 Pain Relevance 0.05
The OX52 antibody to the rat CD6 antigen and the antibody to the T-Cell Receptor (TCR) produced identical surface staining of small rounded or oval cells about 4 ?
Gene_expression (antibody) of CD6
2) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.19 Pain Relevance 0.05
Immunohistochemical analyses of OX-6 expression revealed that kainic acid produced an inflammatory response by increasing the OX-6 positive areas in the hippocampus of kainic acid-injected rats.
Gene_expression (expression) of OX-6 in hippocampus associated with inflammatory response and hippocampus
3) Confidence 0.21 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.88 Pain Relevance 0.53
The expression of OX6 or ED1 immunoreactivity in the synovial lining cells might be involved in the initial immune responses in this arthritis model because the synovial membranes are exposed to the synovial fluids which have been believed to contain antigenic substances.
Gene_expression (expression) of OX6 in synovial fluids associated with arthritis
4) Confidence 0.04 Published 1998 Journal Arch. Histol. Cytol. Section Abstract Doc Link 9990429 Disease Relevance 0.70 Pain Relevance 0.52
OX42 expression level at days 1, 3 and 7, and GFAP expression level at days 3, 7 and 14 were higher in ETM (P<0.05), but not in 30mg/kg METM, than in CON group.
Gene_expression (expression) of OX42
5) Confidence 0.02 Published 2009 Journal Arch. Oral Biol. Section Body Doc Link 19853838 Disease Relevance 0.07 Pain Relevance 0
Chronic, but not acute, morphine administration, induces gliosis characterized by cell hypertrophy, and is associated with increased expression of GFAP [19,27-30] in astrocytes and CD3/CD11B (OX42) in microglia [31].
Gene_expression (expression) of OX42 in microglia associated with hypertrophy, gliosis and morphine
6) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.63 Pain Relevance 0.92
Ultra-low dose naltrexone attenuated morphine-induced increases in the expression of glial fibrillary acidic protein (GFAP) and CD3/CD11B (OX42)
Gene_expression (expression) of OX42 associated with morphine
7) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.16 Pain Relevance 1.36
These cells expressed mostly ED1 (Figure 2C) but rarely MHC class II (OX6; arrow in Figure 2D).
Gene_expression (expressed) of OX6
8) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.19 Pain Relevance 0.09
A few cells containing Rh-Lip also expressed MHC class II molecules (OX6; Figure 1D), suggesting that they correspond to activated macrophages and are capable of Ag presentation.
Gene_expression (expressed) of OX6 in Lip
9) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0

General Comments

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