INT80059

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.85
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptprc)
Ptprc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 92.76 High High
ischemia 15 89.40 High High
cytokine 31 61.96 Quite High
cva 8 60.96 Quite High
Inflammatory response 1 54.08 Quite High
Inflammation 19 37.44 Quite Low
nociceptor 1 25.00 Low Low
agonist 10 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 74 100.00 Very High Very High Very High
Prostate Cancer 112 95.00 High High
Disease 86 93.16 High High
Nociception 2 90.80 High High
Injury 1 90.48 High High
Cv Unclassified Under Development 15 89.40 High High
Cancer 116 81.56 Quite High
Spinal Cord Injury 1 75.00 Quite High
Rectal Cancer 72 68.80 Quite High
Metastasis 36 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A novel immunosuppressive regimen aimed at blocking CD4/CD45 lymphocytic receptors was tested for improving transgene persistence.
Negative_regulation (blocking) of CD45
1) Confidence 0.41 Published 1998 Journal Gene Ther. Section Abstract Doc Link 10023440 Disease Relevance 0.17 Pain Relevance 0.08
Early results of the Dutch trial [38] confirm the decrease in local recurrence with preoperative RT even after optimal surgery with total mesorectal excision.
Negative_regulation (decrease) of RT associated with recurrence
2) Confidence 0.30 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.30 Pain Relevance 0.03
Camma et al. [35] detected a significant reduction in overall mortality with preoperative RT (Table 2).
Negative_regulation (reduction) of RT
3) Confidence 0.30 Published 2003 Journal BMC Med Section Body Doc Link PMC281590 Disease Relevance 0.45 Pain Relevance 0
It has been demonstrated that hydrogen peroxide inhibits CD45 (a transmembrane tyrosine phosphatase expressed in cells of monocytic lineage) [30], and it has recently been shown that the activation of CD45 blocks GM-CSF-induced microglial proliferation [31].
Negative_regulation (inhibits) of CD45
4) Confidence 0.11 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1574293 Disease Relevance 0.33 Pain Relevance 0.13
The number of CD34+/CD45?
Negative_regulation (number) of CD45
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0 Pain Relevance 0
Three days after the last injection, the number of CD34+/CD45?
Negative_regulation (number) of CD45
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0 Pain Relevance 0
The expression of surface markers CD34 (Santa Cruz, USA) and CD45 (Cedarlane Laboratories, Canada) were measured in a LSR II flow cytometer (Becton Dickinson, USA) using the Cell Quest software (Becton Dickinson, USA).
Negative_regulation (measured) of CD45
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0 Pain Relevance 0
Generally, androgen deprivation combined with RT is thought to influence the results of treatment due to local and/or systemic actions.
Negative_regulation (deprivation) of RT
8) Confidence 0.02 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004567 Disease Relevance 0.56 Pain Relevance 0
However, the androgen deprivation given 3 months before and 6 months after the RT was associated with only a 5% rate of positive biopsies.
Negative_regulation (deprivation) of RT
9) Confidence 0.02 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004567 Disease Relevance 0.05 Pain Relevance 0

General Comments

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