INT80075

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2010
Negated 10
Speculated 11
Reported most in Abstract
Documents 55
Total Number 66
Disease Relevance 32.42
Pain Relevance 36.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 33
dorsal root ganglion 15
spinal cord 5
brain 4
arterioles 4
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 695 100.00 Very High Very High Very High
dorsal root ganglion 627 100.00 Very High Very High Very High
Calcitonin gene-related peptide 362 100.00 Very High Very High Very High
Nerve growth factor 324 100.00 Very High Very High Very High
Inflammation 273 100.00 Very High Very High Very High
Pain 247 100.00 Very High Very High Very High
nociceptor 47 100.00 Very High Very High Very High
Root ganglion neuron 22 100.00 Very High Very High Very High
Cannabinoid 21 100.00 Very High Very High Very High
spinal-cord stimulation 16 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 856 100.00 Very High Very High Very High
Pain 222 100.00 Very High Very High Very High
INFLAMMATION 265 99.98 Very High Very High Very High
Diabetes Mellitus 16 99.92 Very High Very High Very High
Bone Cancer 56 99.78 Very High Very High Very High
Nervous System Injury 39 99.56 Very High Very High Very High
Pheochromocytoma 1 99.48 Very High Very High Very High
Neuropathic Pain 272 99.46 Very High Very High Very High
Coronary Artery Disease 8 99.44 Very High Very High Very High
Diabetic Neuropathy 8 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VR1 gene expression in dorsal root ganglia is regulated in response to systemic resiniferatoxin but not peripheral inflammation.
Regulation (regulated) of Gene_expression (expression) of VR1 gene in dorsal root ganglia associated with inflammation
1) Confidence 0.62 Published 2001 Journal Neuroscience Section Abstract Doc Link 11718993 Disease Relevance 0.18 Pain Relevance 0.15
The distribution and regulation of vanilloid receptor VR1 and VR1 5' splice variant RNA expression in rat.
Regulation (regulation) of Gene_expression (expression) of VR1
2) Confidence 0.62 Published 2001 Journal Neuroscience Section Title Doc Link 11718993 Disease Relevance 0.15 Pain Relevance 0.24
Immunohistochemical analysis revealed neuropathy- and antisense-associated regulation of TRPV1 protein expression in spinal cord and dorsal root ganglia.
Regulation (regulation) of Gene_expression (expression) of TRPV1 protein in spinal cord associated with neuropathic pain and spinal cord
3) Confidence 0.62 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17045702 Disease Relevance 0.42 Pain Relevance 0.84
The immunohistochemical staining, cell-size frequency analysis and the survey of average optical density (OD) value were used to observe the changes of TRPV1 expression in the neurons of the trigeminal ganglion (TG), peripheral nerve fibers in the vibrissal pad, and central projection processes in the trigeminal sensory nuclei caudalis (Vc) on day 3, 5, 7, 14, and 21 after TO injection.
Regulation (changes) of Gene_expression (expression) of TRPV1 in neurons
4) Confidence 0.62 Published 2007 Journal Neuroscience bulletin Section Body Doc Link 17592531 Disease Relevance 0.24 Pain Relevance 0
We also used size frequency analysis and double staining with several neuronal markers to investigate whether or not inflammation alters VR1 expression.
Spec (whether) Regulation (alters) of Gene_expression (expression) of VR1 in neuronal associated with inflammation
5) Confidence 0.62 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560124 Disease Relevance 0.76 Pain Relevance 0.42
Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats.
Regulation (Change) of Gene_expression (expression) of vanilloid receptor 1 in dorsal root ganglion associated with nociception, ganglion cysts, dorsal root ganglion, inflammation and spinal dorsal horn
6) Confidence 0.62 Published 2004 Journal Neuroreport Section Title Doc Link 15094470 Disease Relevance 0.64 Pain Relevance 0.83
We investigated the neurotoxic effects of capsaicin (CAP) on pain sensitivity and on the expression of capsaicin receptor, the vanilloid receptor (VR1), in rats.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of capsaicin receptor associated with pain and qutenza
7) Confidence 0.62 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15595420 Disease Relevance 0.36 Pain Relevance 1.10
Our results demonstrate that trigeminal sensory nerve injury induced differential changes in TRPV1 expression of the injured and uninjured TG neurons.
Regulation (changes) of Gene_expression (expression) of TRPV1 in neurons associated with nervous system injury and trigeminal ganglion
8) Confidence 0.62 Published 2008 Journal J Pain Section Abstract Doc Link 18226965 Disease Relevance 1.86 Pain Relevance 1.06
In this study, we examined changes of transient receptor potential vanilloid 1 (TRPV1) expression in the injured and uninjured TG neurons using immunohistochemical analysis at 3 days after surgery, the time point where we observed significant pain hypersensitivity.
Spec (examined) Regulation (changes) of Gene_expression (expression) of TRPV1 in neurons associated with trigeminal ganglion, hypersensitivity and stimulus evoked pain
9) Confidence 0.62 Published 2008 Journal J Pain Section Abstract Doc Link 18226965 Disease Relevance 1.13 Pain Relevance 0.57
Shifting and role of the increased TRPV1 expression in different subtypes of DRG neurons during chronic inflammatory nociception after CFA injection
Regulation (role) of Gene_expression (expression) of TRPV1 in neurons associated with nociception, dorsal root ganglion and inflammation
10) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.61 Pain Relevance 1.30
In the present study, with specific neuronal markers, we demonstrated more clearly the up-regulation of TRPV1 expression in specific subtypes of DRG neurons in CFA inflammatory rats.
Regulation (regulation) of Gene_expression (expression) of TRPV1 in neurons associated with dorsal root ganglion and inflammation
11) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.06 Pain Relevance 0.73
-actin band density was used to calculate the change in TRPV1 expression.


Regulation (change) of Gene_expression (expression) of TRPV1 in band
12) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 0.42 Pain Relevance 0.21
Similarly, there was no change in TRPV1 expression in peripheral terminals, indicated by lack of change in paw skin TRPV1 staining following intrathecal administration of RTX (Fig. 6C).
Neg (no) Regulation (change) of Gene_expression (expression) of TRPV1 in skin associated with intrathecal
13) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.62 Pain Relevance 0.60
We found that hypoxic and high glucose conditions commonly observed in diabetes potentiate TRPV1 activity without affecting TRPV1 expression both in native rat sensory neurons and HEK293 cells expressing rat TRPV1.
Neg (without) Regulation (affecting) of Gene_expression (expression) of TRPV1 in sensory neurons associated with diabetes mellitus and hypoxia
14) Confidence 0.60 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 1.18 Pain Relevance 0.55
Activity and expression of the vanilloid receptor 1 (TRPV1) is altered by long-term diabetes in epineurial arterioles of the rat sciatic nerve.
Regulation (altered) of Gene_expression (expression) of TRPV1 in arterioles associated with qutenza, diabetes mellitus and sciatic nerve
15) Confidence 0.60 Published 2006 Journal Diabetes Metab. Res. Rev. Section Title Doc Link 16196077 Disease Relevance 0.10 Pain Relevance 0.42
These data demonstrate differential regulation of TRPV1 expression between the muscle layers that would result in enhancement of relaxation activity in the longitudinal muscle of the gravid horn during pregnancy, necessary to achieve embryo development and parturition.
Regulation (regulation) of Gene_expression (expression) of TRPV1 in horn
16) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0.05 Pain Relevance 0.03
To evaluate whether growth factor treatment might exert post-transcriptional regulation of TRPV1 gene expression, we next examined their effects on TRPV1 protein levels by Western blot.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of TRPV1
17) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.13 Pain Relevance 0.41
In this study, we determined whether the NADPH oxidase pathway is involved in NGF-stimulated TRPV1 expression using a rat pheochromocytoma 12 line and rat dorsal root ganglion neurons.
Spec (whether) Regulation (involved) of Gene_expression (expression) of TRPV1 in dorsal root ganglion associated with ganglion cysts, nerve growth factor, root ganglion neuron and pheochromocytoma
18) Confidence 0.58 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.28 Pain Relevance 0.33
Capsaicinol: synthesis by allylic oxidation and its effect on TRPV1-expressing cells and adrenaline secretion in rats.
Regulation (effect) of Gene_expression (expressing) of TRPV1 associated with qutenza
19) Confidence 0.45 Published 2006 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 16926503 Disease Relevance 0 Pain Relevance 0.96
The distribution and regulation of vanilloid receptor VR1 and VR1 5' splice variant RNA expression in rat.
Regulation (regulation) of Gene_expression (expression) of VR1
20) Confidence 0.45 Published 2001 Journal Neuroscience Section Title Doc Link 11718993 Disease Relevance 0.15 Pain Relevance 0.24

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