INT80086

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.79
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 8
coronary artery 2
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
aspirin 5 99.74 Very High Very High Very High
Pain 2 99.44 Very High Very High Very High
allodynia 1 98.04 Very High Very High Very High
ischemia 2 96.60 Very High Very High Very High
methadone 3 96.56 Very High Very High Very High
Inflammation 55 93.08 High High
drug abuse 1 91.56 High High
Fibrositis 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 3 98.96 Very High Very High Very High
Pain 1 98.24 Very High Very High Very High
Neuropathic Pain 1 98.04 Very High Very High Very High
Injury 5 97.64 Very High Very High Very High
Atherosclerosis 6 97.48 Very High Very High Very High
Nociception 1 97.48 Very High Very High Very High
Congenital Anomalies 1 96.96 Very High Very High Very High
Cv Unclassified Under Development 2 96.60 Very High Very High Very High
Fibromyalgia 4 95.72 Very High Very High Very High
Increased Venous Pressure Under Development 2 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is still not clear, how aspirin affects expression of major platelet receptors in chronic drug users with coronary artery disease, especially those recovering in the methadone clinic maintenance program.
Regulation (affects) of Gene_expression (expression) of platelet in coronary artery associated with aspirin, coronary artery disease and methadone
1) Confidence 0.60 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11728532 Disease Relevance 0.38 Pain Relevance 0.42
Oral bacteria including Streptococcus sanguis and P. gingivalis have been shown to result in the expression of platelet aggregation proteins that may play a role in the formation of atheromas and thrombi possibly contributing to vascular disease (Herzberg and Meyer 1996, 1998; Sharma et al 2000; Pham et al 2002).
Regulation (result) of Gene_expression (expression) of platelet in platelet associated with atherosclerosis and increased venous pressure under development
2) Confidence 0.44 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.12 Pain Relevance 0.22
The levels of platelet serotonin and CSF substance P appear to be abnormal in directions that could logically amplify pain perception.
Regulation (abnormal) of Gene_expression (levels) of platelet in platelet associated with pain, serotonin and substance p
3) Confidence 0.26 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 10025086 Disease Relevance 0.64 Pain Relevance 0.43
We evaluated the influence of the duration of cold preservation time on the expression of platelet GPIIb/IIIa and P-selectin and on the formation of leukocyte-platelet complexes after kidney transplantation.
Regulation (influence) of Gene_expression (expression) of platelet in platelet
4) Confidence 0.26 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.64 Pain Relevance 0.21
None of the coxibs exerted significant effects on the expression of platelet activation markers, cAMP generation, platelet-leukocyte formation, or on thrombomodulin plasma levels.
Regulation (effects) of Gene_expression (expression) of platelet in platelet
5) Confidence 0.26 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0

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