INT80110

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 25.79
Pain Relevance 9.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocytes 6
peritoneal macrophages 4
skin 4
T cells 4
plasma 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 420 100.00 Very High Very High Very High
Arthritis 122 100.00 Very High Very High Very High
Inflammatory stimuli 4 100.00 Very High Very High Very High
rheumatoid arthritis 361 99.82 Very High Very High Very High
chemokine 34 99.76 Very High Very High Very High
reflex sympathetic dystrophy 21 99.42 Very High Very High Very High
cytokine 682 99.20 Very High Very High Very High
Inflammatory response 56 99.12 Very High Very High Very High
IPN 16 98.42 Very High Very High Very High
Pain 78 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 506 100.00 Very High Very High Very High
Cancer 301 100.00 Very High Very High Very High
Necrosis 70 100.00 Very High Very High Very High
Arthritis 29 100.00 Very High Very High Very High
Rheumatoid Arthritis 436 99.82 Very High Very High Very High
Targeted Disruption 86 99.76 Very High Very High Very High
Myocardial Infarction 39 99.76 Very High Very High Very High
Newcastle Disease 1 99.76 Very High Very High Very High
Complex Regional Pain Syndromes 25 99.42 Very High Very High Very High
Hyperalgesia 35 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
response, no difference in LPS-induced TNF-?
Neg (no) Regulation (difference) of Positive_regulation (induced) of TNF
1) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.89 Pain Relevance 0.46
As seen in Fig. 2a, co-incubation of monocytes of patients with RA with preactivated fixed T cells resulted in significantly lower levels of TNF-?
Regulation (resulted) of Positive_regulation (resulted) of TNF in monocytes associated with rheumatoid arthritis
2) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.81 Pain Relevance 0.41
in RA, T cell-dependent induction of TNF-?
Regulation (dependent) of Positive_regulation (induction) of TNF in T cell associated with rheumatoid arthritis
3) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1297564 Disease Relevance 0.58 Pain Relevance 0.29
However, present knowledge suggests that the highest genetic variability is concentrated in the promoter area of the TNF-?
Regulation (concentrated) of Positive_regulation (area) of TNF
4) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906815 Disease Relevance 0.57 Pain Relevance 0.17
In one recent study of 72 women, depressed women had higher levels of IL-6 and TNF-?
Regulation (had) of Positive_regulation (levels) of TNF
5) Confidence 0.44 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 1.75 Pain Relevance 0.79
These results confirm the findings of Munnikes et al. who studied patients with an intermediate duration of CRPS (median 20 months) and also found a significant elevation of IL-6 and TNF-?
Regulation (found) of Positive_regulation (elevation) of TNF associated with reflex sympathetic dystrophy
6) Confidence 0.44 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 1.00 Pain Relevance 0.61
Depletion in EPCs has been correlated with high levels of TNF-?
Regulation (correlated) of Positive_regulation (levels) of TNF
7) Confidence 0.44 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 1.23 Pain Relevance 0.20
The analysis of the plasma concentrations of IL-6 and TNF-?
Regulation (analysis) of Positive_regulation (concentrations) of TNF in plasma
8) Confidence 0.44 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.10 Pain Relevance 0
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.
Regulation (modulate) of Positive_regulation (participation) of TNF-alpha associated with chemokine, inflammation and arthritis
9) Confidence 0.44 Published 2008 Journal J. Leukoc. Biol. Section Title Doc Link 18515326 Disease Relevance 1.16 Pain Relevance 0.59
Increases in levels of TNF in the brain deeply impact peripheral inflammation through regulating alpha(2)-adrenergic receptors, offering insight into brain-body interactions during neuropathic pain.
Regulation (regulating) of Positive_regulation (Increases) of TNF in brain associated with inflammation and neuropathic pain
10) Confidence 0.41 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 16859892 Disease Relevance 0.76 Pain Relevance 0.96
None of the four agents had an effect on TNF-alpha induced E-selectin expression.
Regulation (effect) of Positive_regulation (induced) of TNF-alpha
11) Confidence 0.41 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.06 Pain Relevance 0
A direct “downregulation” effect of macrophage activation through tmTNF reverse signaling (macrophage anergy or LPS resistance) is included in the macrophage activation term (k3) as follows (bold term):


Regulation (effect) of Positive_regulation (activation) of tmTNF in macrophage
12) Confidence 0.39 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.59 Pain Relevance 0.22
gene expression was observed in a greater proportion of IVDs than TNF?
Regulation (observed) of Positive_regulation (proportion) of TNF
13) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206382 Disease Relevance 0.32 Pain Relevance 0.28
In vitro, human monocytes show a glucose-dependent increase in tumor necrosis factor (TNF)-?
Regulation (dependent) of Positive_regulation (increase) of TNF in monocytes associated with necrosis and cancer
14) Confidence 0.33 Published 2005 Journal Crit Care Section Body Doc Link PMC1414017 Disease Relevance 1.05 Pain Relevance 0.21
In vitro, human monocytes show a glucose-dependent increase in tumor necrosis factor (TNF)-?
Regulation (dependent) of Positive_regulation (increase) of tumor necrosis factor in monocytes associated with necrosis and cancer
15) Confidence 0.33 Published 2005 Journal Crit Care Section Body Doc Link PMC1414017 Disease Relevance 1.00 Pain Relevance 0.21
This finding suggests that the sympathetic nervous system inhibits production of the cytokine and that impaired sympathetic function in heart failure may play a role in the elevated levels of TNF-alpha.
Regulation (role) of Positive_regulation (elevated) of TNF-alpha in sympathetic nervous system associated with myocardial infarction and cytokine
16) Confidence 0.27 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.25 Pain Relevance 0.09
There were no significant differences in the frequency of Th1 or TNF?
Neg (no) Regulation (were) of Positive_regulation (frequency) of TNF
17) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.89 Pain Relevance 0.44
In this study, we evaluated the effects of shikonin and its derivatives on the transcriptional activation of human TNF-alpha promoter in a gene gun-transfected mouse skin system by using a luciferase reporter gene assay.
Regulation (effects) of Positive_regulation (activation) of TNF-alpha in skin
18) Confidence 0.23 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.74 Pain Relevance 0.18
Interestingly, T cells isolated from RA synovial tissue show phenotypical and functional features similar to Tck cells and the above-mentioned signal transduction pathways differentially contribute to the induction of TNF-?
Regulation (contribute) of Positive_regulation (induction) of TNF in T cells associated with rheumatoid arthritis
19) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.73 Pain Relevance 0.43
For example, divergence in the promoter can alter the binding affinity of transcription factors and transcriptional activation of the TNF gene in response to lipopolysaccharide (Baena et al., 2007).
Regulation (alter) of Positive_regulation (activation) of TNF
20) Confidence 0.21 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.46 Pain Relevance 0.29

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