INT80141

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 5.44
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (SPI1) nucleus (SPI1)
Anatomy Link Frequency
macrophages 1
MNCs 1
SPI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 100.00 Very High Very High Very High
Potency 1 87.48 High High
Inflammation 56 73.92 Quite High
Inflammatory response 9 69.44 Quite High
Inflammatory mediators 3 66.00 Quite High
visual analogue scale 12 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
iatrogenic 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Decubitus Ulcers 492 100.00 Very High Very High Very High
INFLAMMATION 72 100.00 Very High Very High Very High
Adhesions 41 96.04 Very High Very High Very High
Sprains And Strains 92 91.44 High High
Diabetes Mellitus 51 88.72 High High
Death 3 84.76 Quite High
Atherosclerosis 24 77.76 Quite High
Insulin Resistance 30 76.96 Quite High
Obesity 18 67.60 Quite High
Diabetes Complications 3 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As of today, there is no evidence that PU prevention is more effective if PU risk scales were used.
Negative_regulation (prevention) of PU associated with decubitus ulcers
1) Confidence 0.08 Published 2010 Journal Journal of multidisciplinary healthcare Section Body Doc Link PMC3004596 Disease Relevance 0.81 Pain Relevance 0
Among others, the outcome of having developed PU is regarded as one indicator of the quality of pressure ulcer prevention,80 but recently it was argued that the measurement of PU occurrence per se has hardly any beneficial effect.81 Instead, one should focus on the whole process of PU prevention including the risk assessment.
Negative_regulation (prevention) of PU associated with decubitus ulcers
2) Confidence 0.08 Published 2010 Journal Journal of multidisciplinary healthcare Section Body Doc Link PMC3004596 Disease Relevance 1.22 Pain Relevance 0
If PU risk assessment based on standardized scales is hardly valid and precise, and if scale use does not lead to a reduction in PU frequency, how can these tools improve clinical care?


Negative_regulation (reduction) of PU associated with decubitus ulcers
3) Confidence 0.07 Published 2010 Journal Journal of multidisciplinary healthcare Section Body Doc Link PMC3004596 Disease Relevance 0.92 Pain Relevance 0
The fact that there is a suppression of PU.1 in parallel with the reduction in mRNA of TLR1, -2, -4, -7, and -9 within 2 h of starting insulin infusion suggests strongly that the suppression of transcription of TLRs by insulin is prompt and is probably mediated by the suppression of this key transcription factor.
Negative_regulation (suppression) of PU.1
4) Confidence 0.07 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.99 Pain Relevance 0.14
CONCLUSIONS—Insulin suppresses the expression of several TLRs at the transcriptional level, possibly through its suppressive effect on PU.1.



Spec (possibly) Negative_regulation (effect) of PU.1
5) Confidence 0.07 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2518353 Disease Relevance 0.22 Pain Relevance 0
The DNA binding of PU.1, a major transcription factor regulating many TLR genes, was concomitantly suppressed by 24 ± 10% (P < 0.05) by 4 h in MNCs.
Negative_regulation (suppressed) of PU.1 in MNCs
6) Confidence 0.07 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2518353 Disease Relevance 0.41 Pain Relevance 0.06
Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI.
Negative_regulation (inhibitor) of SPI associated with inflammation and cinod
7) Confidence 0.07 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10027849 Disease Relevance 0.10 Pain Relevance 0.14
Finally, multi-copy expression of PagN can compensate for the loss of the SPI-1 encoded T3SS.


Negative_regulation (loss) of SPI-1
8) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2553418 Disease Relevance 0.41 Pain Relevance 0
Within macrophages the SPI-1 T3SS is strongly downregulated [28] and Salmonella that exit such cells may have to rely on PagN to facilitate subsequent interactions with cells until such time as the T3SS is maximally expressed.
Negative_regulation (downregulated) of SPI-1 T3SS in macrophages
9) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2553418 Disease Relevance 0.36 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox