INT80142

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Context Info
Confidence 0.21
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
PGE2 4
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 100.00 Very High Very High Very High
Analgesic 2 92.36 High High
Potency 1 90.00 High High
Inflammation 5 84.40 Quite High
Pain 1 83.72 Quite High
Inflammatory mediators 2 75.00 Quite High
cytokine 1 44.40 Quite Low
antagonist 1 30.24 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 5 98.72 Very High Very High Very High
INFLAMMATION 9 92.72 High High
Toxicity 1 88.96 High High
Ulcers 3 88.64 High High
Pain 1 83.72 Quite High
Cancer 4 79.20 Quite High
Necrosis 1 78.72 Quite High
Peptic Ulcer 1 75.00 Quite High
Intestinal Cancer 1 70.64 Quite High
Apoptosis 1 39.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The IC50-values obtained for the inhibition of lipopolysaccharide (LPS)-induced release of prostaglandin E2 (PGE2) reflecting cyclooxygenase (COX)-2-mediated PGE2 release were 47 microg/ml and 0.6 microg/ml, for the Salix extract 1520L and rofecoxib-like research compound L745337, respectively.
Positive_regulation (induced) of Localization (release) of cyclooxygenase in PGE2
1) Confidence 0.21 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.40 Pain Relevance 0.26
Long-term use of cyclooxygenase (COX) inhibitors (NSAIDs) in humans leads to a 50% reduction in risk for colorectal cancer.
Positive_regulation (leads) of Localization (use) of cyclooxygenase associated with colon cancer and cinod
2) Confidence 0.19 Published 2007 Journal Cell Cycle Section Abstract Doc Link 17374999 Disease Relevance 0.56 Pain Relevance 0.14
It has been suggested that indomethacin induces gastric damage via inhibiting the release of protective factors like cyclooxygenase-1 (COX-1), prostaglandin E2 (PGE2), bicarbonate, and mucus; increasing aggressive factors like acid; and increasing oxidant parameters while decreasing antioxidant parameters.
Positive_regulation (induces) of Localization (release) of cyclooxygenase-1 in PGE2
3) Confidence 0.05 Published 2010 Journal Inflammation Section Abstract Doc Link 20084447 Disease Relevance 0.48 Pain Relevance 0.35
LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase.
Positive_regulation (inducible) of Localization (forms) of cyclooxygenase
4) Confidence 0.03 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.07 Pain Relevance 0.12

General Comments

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