INT80147

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
hindbrain 2
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 2 100.00 Very High Very High Very High
opiate 1 95.04 Very High Very High Very High
Neurotransmitter 6 94.92 High High
gABA 14 94.52 High High
Central nervous system 10 85.04 High High
antagonist 18 78.52 Quite High
agonist 29 77.88 Quite High
adenocard 92 70.08 Quite High
depression 3 66.28 Quite High
long-term potentiation 2 65.32 Quite High
Disease Link Frequency Relevance Heat
Neurological Disease 5 83.12 Quite High
Depression 3 66.28 Quite High
Adhesions 1 18.48 Low Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in hindbrain, A2AR-stimulated [35S]GTPgammaS binding decreases during postnatal development in parallel with the decrease in A2AR levels, whereas [35S]GTPgammaS binding stimulated by other neurotransmitter receptor systems increases in parallel with basal [35S]GTPgammaS binding.
Negative_regulation (decreases) of A2AR Binding (binding) of in hindbrain associated with neurotransmitter
1) Confidence 0.43 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.35
Interactions with metabotropic dopamine receptors as well as A2A, A3, NPY, and P2Y1 receptors will be described in the first part.
Negative_regulation (described) of A2A Binding (Interactions) of associated with dopamine receptor
2) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.15 Pain Relevance 0.42

General Comments

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