INT80159

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.47
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ucn)
Anatomy Link Frequency
pituitary 1
enteric nervous system 1
anterior pituitary 1
Ucn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
psoriasis 1 97.28 Very High Very High Very High
Peripheral nervous system 4 94.52 High High
antagonist 123 92.00 High High
Central nervous system 1 90.60 High High
lidocaine 1 88.92 High High
local anesthetic 1 88.52 High High
Neuropeptide 16 83.00 Quite High
substance P 49 71.52 Quite High
tetrodotoxin 3 61.24 Quite High
Calcitonin gene-related peptide 52 56.08 Quite High
Disease Link Frequency Relevance Heat
Stress 147 99.48 Very High Very High Very High
Eczema 1 98.12 Very High Very High Very High
Psoriasis 1 97.28 Very High Very High Very High
Increased Venous Pressure Under Development 4 57.96 Quite High
Edema 1 52.80 Quite High
Targeted Disruption 66 46.68 Quite Low
Hypopituitarism 3 33.68 Quite Low
INFLAMMATION 84 5.00 Very Low Very Low Very Low
Cancer 66 5.00 Very Low Very Low Very Low
Pituitary Cancer 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect of Ucn may explain stress-induced disorders, such as atopic dermatitis or psoriasis, and may lead to new forms of treatment.
Gene_expression (effect) of Ucn associated with stress, psoriasis and eczema
1) Confidence 0.67 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027877 Disease Relevance 0.41 Pain Relevance 0.52
Urocortin I is present in the enteric nervous system and exerts an excitatory effect via cholinergic and serotonergic pathways in the rat colon.
Gene_expression (present) of Urocortin I in enteric nervous system
2) Confidence 0.56 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17717045 Disease Relevance 0 Pain Relevance 0.20
To date, no evidence for the expression of urocortin III in the pituitary has been found (589).
Gene_expression (expression) of urocortin in pituitary
3) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.03
The urocortin gene is highly expressed in the anterior pituitary of the rat and human (584, 585).
Gene_expression (expressed) of urocortin gene in anterior pituitary
4) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
CRH and urocortin peptides
Gene_expression (peptides) of urocortin
5) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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