INT80160

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ucn)
Ucn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 98.64 Very High Very High Very High
noradrenaline 1 95.72 Very High Very High Very High
substance P 1 94.56 High High
Neuropeptide 1 90.88 High High
local anesthetic 1 80.16 Quite High
Calcitonin gene-related peptide 1 79.12 Quite High
lidocaine 1 78.80 Quite High
Peripheral nervous system 1 68.88 Quite High
psoriasis 1 49.44 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 81.00 Quite High
Edema 1 75.84 Quite High
Stress 3 69.24 Quite High
Psoriasis 1 5.00 Very Low Very Low Very Low
Eczema 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vasodilatory effect of Ucn was largely inhibited by pretreatment with H1 receptor antagonists, suggesting that histamine is the major mediator involved in vitro.
Negative_regulation (inhibited) of Ucn associated with antagonist
1) Confidence 0.58 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027877 Disease Relevance 0.29 Pain Relevance 0.51
The depressor effect of urocortin was unaffected by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME, inhibitor of NO synthase, i.v. bolus) or noradrenaline (i.v. infusion), which increased arterial pressure to a similar level as that produced by L-NAME.
Neg (unaffected) Negative_regulation (unaffected) of urocortin associated with noradrenaline
2) Confidence 0.18 Published 2005 Journal Pharmacology Section Abstract Doc Link 15604589 Disease Relevance 0 Pain Relevance 0.05

General Comments

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